Apr 29, 2022

Researchers find a genetic cause for lupus

Posted by in categories: biotech/medical, genetics


A team of international researchers have identified a genetic cause of lupus. Researchers of the study pinpointed that DNA mutations in a gene that senses viral RNA represents one cause of the chronic condition, affecting approximately 1 in 1,000 people living in the UK. It is important to note that this genetic cause is not the sole trigger for everyone affected by lupus.

Researchers of the study sequenced the whole DNA genome of a juvenile systemic lupus erythematosus (JSLE) patient called Gabriela, who was diagnosed with severe lupus at the age of seven. A severe case such as this, with early onset of symptoms, is a rarity and is commonly associated with a single genetic cause, unlike adult-onset lupus.

The researchers that carried out the genetic analysis identified a single point mutation in the Toll Like Receptor 7 (TLR7) gene. Furthermore the researchers discovered other cases of severe lupus where this gene was also mutated.

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