Toggle light / dark theme

Blood plasma, cellular reprogramming, endogenous.


You may have heard a lot of talk recently about cellular reprogramming, rejuvenation or even “rejuvenation programming”, but what does that all mean and what are the 3 main strategies that several researchers and companies (maybe Altos Labs) will be further investigating?

Well i discuss in this video.

Find me on Twitter — https://twitter.com/EleanorSheekey.

Support the channel.

FeaturedRead our 3 books at https://lifeboat.com/ex/books.

The Lifeboat Foundation is a nonprofit nongovernmental organization dedicated to encouraging scientific advancements while helping humanity survive existential risks and possible misuse of increasingly powerful technologies, including genetic engineering, nanotechnology, and robotics/AI, as we move towards the Singularity.

Lifeboat Foundation is pursuing a variety of options, including helping to accelerate the development of technologies to defend humanity, such as new methods to combat viruses, effective nanotechnological defensive strategies, and even self-sustaining space colonies in case the other defensive strategies fail.

We believe that, in some situations, it might be feasible to relinquish technological capacity in the public interest (for example, we are against the U.S. government posting the recipe for the 1918 flu virus on the internet). We have some of the best minds on the planet working on programs to enable our survival. We invite you to join our cause!

Visit our site at https://lifeboat.com. Participate in our programs at https://lifeboat.com/ex/programs. Follow our Twitter feed at https://twitter.com/LifeboatHQ and our GETTR feed at https://gettr.com/user/LifeboatHQ. Watch our YouTube channel at https://youtube.com/lifeboathq. Read our blog at https://lifeboat.com/blog. Join our LinkedIn group at https://www.linkedin.com/groups/35656. Subscribe to our newsletter at https://lifeboat.com/newsletter.cgi.

Interact with the author of “The Human Race to the Future: What Could Happen—and What to Do” at https://www.facebook.com/groups/thehumanracetothefuture.


A platform for single-molecule measurement of binding kinetics & enzyme activity.

The first molecular electronics chip has been developed, realizing a 50-year-old goal of integrating single molecules into circuits to achieve the ultimate scaling limits of Moore’s Law. Developed by Roswell Biotechnologies and a multi-disciplinary team of leading academic scientists, the chip uses single molecules as universal sensor elements in a circuit to create a programmable biosensor with real-time, single-molecule sensitivity and unlimited scalability in sensor pixel density. This innovation, appearing this week in a peer-reviewed article in the Proceedings of the National Academy of Sciences (PNAS), will power advances in diverse fields that are fundamentally based on observing molecular interactions, including drug discovery, diagnostics, DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” said Bennett.

The heart was provided by Revivicor, a company based in Virginia that has been engineering pig organs for roughly two decades. In several experiments for pig-to-baboon transplants, the organs survived up to nine months, until the animals passed away due to a lung infection unrelated to the transplant.

Overall, the heart had 10 hefty genetic edits. Three of them wiped out sugar molecules on the outside of cells that provoke an immune response. Six bolstered the chance of the human host accepting the heart—amping up an anti-inflammatory response, preventing blood vessel damage, and dampening any antibodies against the organ. Finally, the last edit limited the pig heart’s size. Although it generally matched the size of a human heart, the team wanted to prevent the pig organ from overgrowth inside Bennett’s chest once it was transplanted—something they previously noticed happened in baboons.

And it took less than a full workday. Stanford Medicine scientists and their collaborators have engineered a new genome sequencing technique that can diagnose rare genetic diseases in an average of eight hours. This is a record-breaking time frame that is leap and bounds ahead of other current advanced technologies.


Gene sequencing is crucial to advancing science! Check out why cutting time and cost is key.

Circa 2019


The race to engineer the next-generation banana is on. The Colombian government confirmed last month that a banana-killing fungus has invaded the Americas — the source of much of the world’s banana supply. The invasion has given new urgency to efforts to create fruit that can withstand the scourge.

Scientists are using a mix of approaches to save the banana. A team in Australia has inserted a gene from wild bananas into the top commercial variety — known as the Cavendish — and are currently testing these modified bananas in field trials. Researchers are also turning to the powerful, precise gene-editing tool CRISPR to boost the Cavendish’s resilience against the fungus, known as Fusarium wilt tropical race 4 (TR4).

Breeding TR4 resistance into the Cavendish using conventional methods isn’t possible because the variety is sterile and propagated by cloning. So the only way to save the Cavendish may be to tweak its genome, says Randy Ploetz, a plant pathologist at the University of Florida in Homestead. The variety accounts for 99% of global banana shipments.

Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=jhKZIq3SlYE
Please support this podcast by checking out our sponsors:
- Onnit: https://lexfridman.com/onnit to get up to 10% off.
- Clear: https://clearme.com/lexpod and use code LexPod to get 2 months free.
- National Instruments (NI): https://www.ni.com/perspectives.
- SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera.
- Linode: https://linode.com/lex to get $100 free credit.

GUEST BIO:
David Sinclair is a geneticist at Harvard and author of Lifespan.

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast.
Apple Podcasts: https://apple.co/2lwqZIr.
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4
Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41

SOCIAL:
- Twitter: https://twitter.com/lexfridman.
- LinkedIn: https://www.linkedin.com/in/lexfridman.
- Facebook: https://www.facebook.com/lexfridman.
- Instagram: https://www.instagram.com/lexfridman.
- Medium: https://medium.com/@lexfridman.
- Reddit: https://reddit.com/r/lexfridman.
- Support on Patreon: https://www.patreon.com/lexfridman

Church points to factors that helped make such a success of three of the top COVID-19 vaccine technologies. For one thing, they all used gene therapy technologies, and each was a new method relative to the past and to each other. For instance, the AstraZeneca vaccine was based on an adenovirus capsid containing double-stranded DNA as opposed to an adeno-associated virus (AAV) of the Johnson & Johnson/Janssen vaccine, while the Moderna and Pfizer/BioNTech vaccines were based on single-stranded mRNA inside lipid nanoparticles.

“Implementation science is the unsung handmaiden of biomedical discovery!”

Secondly, each of them was approved by the FDA 10 times faster than the vast majority of therapeutic products, and finally, the cost per vaccine has been as low as $2 per dose for the United Nations’ COVAX global access program. That’s about a million times cheaper than Zolgensma, he says, referring to the AAV gene therapy medication used to treat spinal muscular atrophy. So since “any one of these could spark a revolution,” according to Church, imagine what could happen in the next 12 months if all four factors pertain again?