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Blood Type Linked to Risk of Stroke Before Age 60

According to a new meta-analysis, gene variants associated with a person’s blood type may be linked to their risk of early stroke.

“Non-O blood types have previously been linked to a risk of early stroke, but the findings of our meta-analysis showed a stronger link between these blood types with early stroke compared to late stroke, and in linking risk mostly to blood type A,” said study author Braxton D. Mitchell, PhD, MPH, of University of Maryland School of Medicine in Baltimore. “Specifically, our meta-analysis suggests that gene variants tied to blood types A and O represent nearly all of those genetically linked with early stroke. People with these gene variants may be more likely to develop blood clots, which can lead to stroke.”

48 studies on genetics and ischemic stroke from North America, Europe, and Asia were reviewed in the meta-analysis. 16,927 people with stroke and 576,353 people who did not have a stroke were included in the studies. Of those with stroke, 5,825 people had early onset stroke and 9,269 people had late onset stroke. Early onset stroke was defined as an ischemic stroke occurring before age 60 and late-onset stroke was older than 60 years old.

Groundbreaking Alzheimer’s Case: Gene APOE3

An alzheimer’s-proof brain: a groundbreaking case.


In a groundbreaking case researchers from the Massachusetts General Hospital have discovered a gene variant that seems to have disrupted the pathology of Tau Protein. The case of Aliria Rosa Piedrahita de Villegas.

Abstract: Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia.

https://link.springer.com/article/10.1007/s00401-022-02467-8

Nature’s Lab Teaches Alzheimer’s Prevention:

Artificial pieces of brain use light to communicate with real neurons

Researchers have created a way for artificial neuronal networks to communicate with biological neuronal networks. The new system converts artificial electrical spiking signals to a visual pattern than is then used to entrain the real neurons via optogenetic stimulation of the network. This advance will be important for future neuroprosthetic devices that replace damages neurons with artificial neuronal circuitry.

A prosthesis is an artificial device that replaces an injured or missing part of the body. You can easily imagine a stereotypical pirate with a wooden leg or Luke Skywalker’s famous robotic hand. Less dramatically, think of old-school prosthetics like glasses and contact lenses that replace the natural lenses in our eyes. Now try to imagine a prosthesis that replaces part of a damaged brain. What could artificial brain matter be like? How would it even work?

Creating neuroprosthetic technology is the goal of an international team led by by the Ikerbasque Researcher Paolo Bonifazi from Biocruces Health Research Institute (Bilbao, Spain), and Timothée Levi from Institute of Industrial Science, The University of Tokyo and from IMS lab, University of Bordeaux. Although several types of artificial neurons have been developed, none have been truly practical for neuroprostheses. One of the biggest problems is that neurons in the brain communicate very precisely, but electrical output from the typical electrical neural network is unable to target specific neurons. To overcome this problem, the team converted the electrical signals to light. As Levi explains, “advances in optogenetic technology allowed us to precisely target neurons in a very small area of our biological neuronal network.”

Deinococcus radiodurans — the consummate survivor

Circa 2005 Bacteria that is resistant to radiation could lead to better radiation resistance in humans.


Relatively little is known about the biochemical basis of the capacity of Deinococcus radiodurans to endure the genetic insult that results from exposure to ionizing radiation and can include hundreds of DNA double-strand breaks. However, recent reports indicate that this species compensates for extensive DNA damage through adaptations that allow cells to avoid the potentially detrimental effects of DNA strand breaks. It seems that D. radiodurans uses mechanisms that limit DNA degradation and that restrict the diffusion of DNA fragments that are produced following irradiation, to preserve genetic integrity. These mechanisms also increase the efficiency of the DNA-repair proteins.

Scientists Are Working on a Gene-Hacking Drug That Could Treat Baldness

Using gene modification techniques, a team of researchers have come up with a new treatment for balding, Wired reports — a condition experienced to varying degrees by two-thirds of American men by age 35.

The team, associated with the University of California, Irvine and a biotech company called Amplifica, believes they’ve identified the signaling pathway that drive hair growth to find new ways to stop stem cells from giving up on producing hair follicles.

Experiments with mice, as detailed in a new paper published in the journal Developmental Cell last month, have been promising. The mice were genetically modified to have the hair growth signaling pathway turned on permanently.

DHEA-S Is A Weakness In My Data: Blood Test #5 in 2022

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Scientists Solve Century-Old Supergene Mystery

Researchers have solved the century-old mystery of a supergene that causes efficient cross-pollination in flowers. The results reveal that sequence length variation at the DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Rewriting Our Understanding of Epigenetics: Scientists Reveal We Inherit More Than Previously Thought

A fundamental discovery concerning a driver of healthy development in embryos might rewrite our understanding of what we can inherit from our parents and how their life experiences shape us. The new study reveals that epigenetic information, which sits on top of DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

10 Seconds to the Future | Mutation | Free Documentary

2077 — 10 Seconds to the Future — Mutation | Science Documentary.

2077 — 10 Seconds to the Future | Global Estrangement: https://youtu.be/CTOduDIkcdM

We are at the starting line of an exponential technological change. In the coming decades we will experience the dematerialization of technology. Computers will abandon desks to be installed in eyes, in walls and in everything that surrounds us. Chips will be integrated in virtually everything around us, transmitting vital information. The quality of life and the average life expectancy will increase astoundingly, and aging will be delayed. We will have the capacity to choose genes for our children and to create new forms of life. In 2007, a smartphone had more power than the computers NASA used to take man to the moon in 1969. In 2077 it’s likely that we will control the objects around us through our thought. The opinion that the revolution under way is the biggest and fastest ever is unanimous, with the interception of genetics, nanotechnology and artificial intelligence. The consequences are many and cross-cutting, with great impact on our health. However, the rise of the machine raises unprecedented challenges, even the possibility of the extinction of Humankind itself.
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