Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: genetics – Page 183

Foreign DNA ‘sneaks’ past bacterial defenses, aiding antibiotic resistance

A new study by Tel Aviv University reveals how bacterial defense mechanisms can be neutralized, enabling the efficient transfer of genetic material between bacteria. The researchers believe this discovery could pave the way for developing tools to address the antibiotic resistance crisis and promote more effective genetic manipulation methods for medical, industrial, and environmental purposes.

The study was led by Ph.D. student Bruria Samuel from the lab of Prof. David Burstein at the Shmunis School of Biomedicine and Cancer Research at Tel Aviv University’s Wise Faculty of Life Sciences. Other contributors to the research include Dr. Karin Mittelman, Shirly Croitoru, and Maya Ben-Haim from Prof. Burstein’s lab. The findings were published in the journal Nature.

The researchers explain that genetic diversity is essential for the survival and adaptation of different species in response to environmental changes. For humans and many other organisms, sexual reproduction is the primary driver of the genetic diversity required for survival. However, bacteria and other microorganisms lack such a reproduction mechanism.

AI-designed ‘nanocages’ mimic viral behavior for enhanced gene therapy

Researchers have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI). Their pioneering research was published in Nature on December 18.

Viruses are uniquely designed to encapsulate genetic material within spherical shells, enabling them to replicate and invade host cells, often causing disease. Inspired by these complex structures, researchers have been exploring artificial proteins modeled after viruses.

These “nanocages” mimic viral behavior, effectively delivering therapeutic genes to target cells. However, existing nanocages face significant challenges: their small size restricts the amount of genetic material they can carry, and their simple designs fall short of replicating the multifunctionality of natural viral proteins.

Simple Dietary Supplement Could Supercharge Cancer-Fighting Immune Cells

A dietary supplement may offer a novel way to enhance the effectiveness of CAR T cell therapy, according to a study conducted by researchers at the Perelman School of Medicine and the Abramson Cancer Center at the University of Pennsylvania. Although this method requires validation through clinical trials, early findings—recently presented during a press briefing at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition—suggest a potentially affordable and accessible strategy to improve CAR T cell functionality and cancer-fighting capabilities.

CAR T cell therapy, first developed at Penn Medicine, is a personalized cancer treatment that reprograms a patient’s immune cells to target and destroy cancer cells.

“Thousands of patients with blood cancers have been successfully treated with CAR T cell therapy, but it still doesn’t work for everyone,” said co-lead author Shan Liu, PhD, a postdoctoral fellow who presented the study at ASH. “We took an outside-the-box approach to improve CAR T cell therapy, by targeting T cells through diet rather than further genetic engineering.”

17.2y Younger Biological Age (Blood Test #8 In 2024, Test #56 Since 2015)

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “17.2y Younger Biological Age (Blood Test #8 In 2024, Test #56 Since 2015)” | >

Theurgy and Transhumanism

Theurgy was a system of magical practices in the late Roman Empire. It was applied Neoplatonism. The theurgists aimed to enable human bodies to assume divine attributes, that is, to become deities. I aim to show that much of the structure of theurgical Neoplatonism appears in transhumanism. Theurgists and transhumanists share a core Platonic-Pythagorean metaphysics. They share goals and methods. The theurgists practiced astrology, the reading of entrails, the consultation of oracles, channeling deities, magic, and the animation of statues. The transhumanist counterparts of those practices are genetics, self-tracking with biosensors, artificial intellects like Google and Siri, brain-computer interfaces, programming, and robotics. Transhumanist techno-theurgy shows how Neoplatonism can be a modern philosophical way of life.

See full PDFdownloadDownload PDF.

Morphological evidence supporting four giraffe species classifications

The University of Cape Town, along with the Giraffe Conservation Foundation, have conducted a large-scale study identifying significant cranial shape differences between four genetically distinct giraffe species. The findings suggest that these species exhibit unique developmental and morphological characteristics, which have implications for conservation efforts.

Taxonomic classification is critical for guiding good conservation strategies. Giraffes have long been categorized as one species with geographic variants, though advancements in research are reshaping this perspective.

In the study, “Heads Up—Four Giraffa Species Have Distinct Cranial Morphology,” published in PLOS ONE, researchers examined 515 skulls with 3D geometric morphometrics to analyze patterns of cranial variability. The dataset, the largest of its kind, included specimens from , wild populations, and taxidermy sources across Africa.

Genetic tweak to three key crops massively boosts their growth

The growth of maize, sugarcane and sorghum has been greatly boosted by modifying the plants to take advantage of higher carbon dioxide levels now found in the air.

This was done by simply increasing the activity of two genes, says Coralie Salesse-Smith at the University of Illinois. The finding should lead to the creation of new varieties whose yields go up as CO2 levels continue to rise.

For most of the time that photosynthetic cells that turn sunlight into food have existed, atmospheric levels of CO2 have been much higher (and the planet has been much hotter). As CO2 levels fell particularly low from about 35 million years ago, it exacerbated a fundamental flaw in photosynthesis that involves probably the most abundant protein on the planet, called rubisco.

Image: Przemyslaw Koch/Getty Images

A simple change to maize, sorghum and sugarcane that allows them to take advantage of rising CO2 levels can boost their growth by around a fifth.

By Michael Le Page

Continue reading “Genetic tweak to three key crops massively boosts their growth” | >

GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function

Furthermore, GDF-15 levels have been positively associated with the aging process. In fact, Tanaka et al. (Tanaka et al. 2018) showed that this cytokine had the strongest positive correlation with age in humans, and several reports describe higher levels of GDF-15 in older individuals (Semba et al. 2020; Doerstling et al. 2018; Liu et al. 2020). Aging is characterized by a decline in physiological function and changes in body composition, being a major risk factor for a variety of chronic diseases. As such, GDF-15 is also associated with several age-related diseases, including cardiovascular disease (Echouffo-Tcheugui et al. 2021), cancer (Wischhusen et al. 2020), metabolic syndrome (Ho et al. 2023; Carballo-Casla et al. 2022), or diabetes (Ouyang et al. 2020; Merchant et al. 2023), among others (Candia et al. 2021; Iglesias et al. 2023). In addition, it has been proposed as a biomarker for the risk of death in patients with cardiovascular conditions and an accurate all-cause mortality marker (Candia et al. 2021; Iglesias et al. 2023; Nopp et al. 2021). GDF-15 has also been positively associated with deteriorated muscle function and sarcopenia (Semba et al. 2020; Kim et al. 2022, 2020; Nakajima et al. 2019; Lee et al. 2022), a highly prevalent condition among the elderly that increases the risk of frailty (Picca et al. 2020).

It is widely accepted that human aging may be influenced by epigenetic alterations (López-Otín et al. 2023). In this sense, age biomarkers based on DNA methylation have proven useful in predicting the risk of age-related diseases and mortality (Fransquet et al. 2019). Among several developed epigenetic clocks, DNAm GrimAge has shown a higher prediction capacity of mortality and morbidity risk (Lu et al. 2022). Notably, GDF-15 is one of the markers included for the calculation of this clock (Lu et al. 2019). Thus, understanding the interplay between GDF-15 and aging can be crucial for improving the assessment of and management of age-associated conditions.

For all this, the aim of this study was to characterize the changes in circulating GDF-15 levels with age in a population of healthy individuals from the Balearic Islands and investigate its potential associations with different epigenetic and biological clocks, physical performance and other age-related biomarkers.

/* */