Cells in the human body, the building blocks of life, are arranged in a precise way. That’s necessary because pathways and spaces provide a means for cells to communicate, collaborate and function within the specific tissue or organ. Changes in cell arrangement can lead to uncontrolled cell growth, cell death and diseases, including cancer.
Scientists at the Mayo Clinic Center for Individualized Medicine and Mayo Clinic Comprehensive Cancer Center have developed an artificial intelligence method, called Spatially Informed Artificial Intelligence (SPIN-AI). This new deep-learning technique can analyze the genetic information of individual cells to reconstruct the precise layout of the cells in a tissue, without preexisting knowledge of how the cells are organized.
The new study detailing SPIN-AI is published in Biomolecules.
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