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Category: genetics – Page 115

The team used acupuncture needles to deliver the trigger for 10 seconds a day, and the blood sugar levels in the mice returned to normal within a month. The rodents even regained the ability to manage blood sugar levels after a large meal without the need for external insulin, a normally difficult feat.

Called “electrogenetics,” these interfaces are still in their infancy. But the team is especially excited for their potential in wearables to directly guide therapeutics for metabolic and potentially other disorders. Because the setup requires very little power, three AA batteries could trigger a daily insulin shot for more than five years, they said.

The study is the latest to connect the body’s analogue controls—gene expression—with digital and programmable software such as smartphone apps. The system is “a leap forward, representing the missing link that will enable wearables to control genes in the not-so-distant future,” said the team.

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Continue reading “Increase NAD With Fish Oil (And Other PUFA-Containing) Fatty Acids? Hypothesis” | >

Summary: Researchers uncovered how distinct neuron types in the Drosophila fruit fly differentiate their functions despite originating from a similar genetic framework.

In the study, two closely related neuronal subtypes expressed more than 800 different genes (~5% of the fly genome) differently. This gene expression directly influenced the observable distinctions between the neuron types.

The findings help illuminate the brain’s intricate cell development and how disease could affect it.

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“Because of the heterogeneity of this disease, scientists haven’t found good ways of tackling it,” said Olivier Gevaert, PhD, associate professor of biomedical informatics and of data science.

Doctors and scientists also struggle with prognosis, as it can be difficult to parse which cancerous cells are driving each patient’s glioblastoma.

But Stanford Medicine scientists and their colleagues recently developed an artificial intelligence model that assesses stained images of glioblastoma tissue to predict the aggressiveness of a patient’s tumor, determine the genetic makeup of the tumor cells and evaluate whether substantial cancerous cells remain after surgery.

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Now maybe we can snack happily! I think this applies to regular food too? I can eat all the Chinese and Mexican and Italian food I want? Plus for people with genetic risks can’t this not help? I hope so.

Mice fed a high-sugar, high-fat diet for most of their lives managed to escape weight gain and protect their livers when they were treated with an experimental new drug.

The small-molecule drug was developed by a team led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio). K nown by its chemical acronym CPACC, it works by limiting the entry of magnesium into the mitochondria, the parts of the cell in charge of generating energy and burning calories.

Mitochondrial abnormalities have been implicated in a range of diseases, including obesity, diabetes, and cardiovascular disease.

Continue reading “Scientists Develop Drug That Prevents Weight Gain in Junk-Food-Eating Mice” | >

Likewise, this dataset had 4,510 cases, 212,242 controls, with 16,380,464 SNPs for psoriasis, and 2,802 cases, 212,242 controls, with 16,380,459 SNPs for psoriasis vulgaris.

The team analyzed the aggregated statistical data using an MR approach to explore the potential causal relationship between the gut microbiome and psoriasis. SNPs with a threshold P-value of 1 × 10−5 worked as genetic instrumental variables in these MR analyses.

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A new study from the University of Minnesota is the first to demonstrate the ability for gene therapy to repair neural connections for those with the rare genetic brain disorder known as Hurler syndrome. The findings suggest the use of gene therapies—an entirely new standard for treatment—for those with brain disorders like Hurler syndrome, which have a devastating impact on those affected.

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Continue reading “Uremic Metabolites: Kidney Function Biomarkers” | >