Simple SummaryThe tumor microenvironment is a complex network comprised of neoplastic and a variety of immune cells, proteins, and inflammatory mediators.

Now online! The cryo-EM structures of Andes hantavirus (ANDV) glycoprotein tetramers, dimers of tetramers, and ADI-65534 Fab complexes on eVLPs unveil the molecular basis of New World hantavirus glycoprotein architecture, acid-induced membrane fusion, and antibody-mediated neutralization. Immunization with repRNA encoding ANDV-VLPs elicits high neutralizing-antibody titers.

Researchers have uncovered an unusual new form of aluminium that challenges long-held assumptions about how this common metal behaves. Researchers at King’s College London have identified an unusual new form of aluminum, one of the most abundant metals in Earth’s crust. The discovery points to a

One of the least examined—but most consequential—dimensions of intelligence is not merely what a mind can represent, but the temporal resolution at which cognition unfolds. Intelligence is inseparable from subjective time: the rate at which experiences, d

Your tear film protects your eyes. It is composed of 3 main layers: Meibomian gland dysfunction (MGD) is a common eye condition that often goes unnoticed until it causes discomfort and irritation. When these glands don’t function properly, it leads to MGD. Causes of Meibomian Gland Dysfunction MGD can be caused by a combination of

Now online! Yibo et al. identify protein pyruvylation as a post-translational modification that can modulate immune signaling and host antiviral response.

Saikali et al. describe differential compartmentalization of GATA-3 in Th cell and ILC subsets. Changing it modifies functional characteristics of the cells. Importin-β mediates GATA-3’s nuclear import. The short half-life of nuclear GATA-3 necessitates continuous GATA-3 import to maintain Th2 cell function. GATA-3’s nuclear import is a critical rheostat of lymphocytes.

Calcium influx through CRAC channels requires STIM1 binding to Orai1. Using crosslinking and mutagenesis, Söllner et al. show that widening the nexus-TM3 interface near the STIM1 coupling site is crucial for channel opening, while hydrophobicity and charges support signal transmission to the pore. Nexus-TM3 dynamics are vital for Orai1 function.

Ráez-Meseguer, C., Navas-Enamorado, C., Capó, X. et al. MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan. npj Aging 12, 30 (2026). https://doi.org/10.1038/s41514-025-00321-1

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Aarhus University chemist Troels Skrydstrup and his team recently debuted their efforts to turn nitrile rubber, of the kind used in laboratory and medical gloves, into polyamine membranes that sequester carbon dioxide.

Chemists upcycle nitrile rubber into carbon-sequestering polyamines by Brianna Barbu.