NOAA measures a giant Mariana Islands megacoral that may be over 2,000 years old in a stunning undersea volcano setting.
Category: futurism – Page 89
Citraconate preserves T cell stemness and antitumor immunity
The metabolite citraconate can preserve T cell stemness and suppress exhaustion, promoting antitumor immunity and responses to immunotherapies in mice.
Learn more in Science Immunology.
Sci. Immunol. 11, eadz0348 (2026). DOI:10.1126/sciimmunol.adz0348
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Cell proteins that drive severe viral infections identified
In two recently published studies, the nucleoporins NUP98 and NUP153 have been identified as key host factors in orthoflavivirus infection.
NUP98 and NUP153 are normally part of the nuclear pore complex, which regulates the transport of proteins and RNA between the cell nucleus and the cytosol, the fluid in which the cell’s internal components are suspended. Since orthoflaviviruses copy their RNA in the cytosol, these proteins had not previously been linked to the viral life cycle.
The researchers now show that during infection, both nucleoporins are recruited to viral replication sites in the cytosol, where they bind directly to viral RNA. In addition, NUP153 also interacts with viral proteins.
“It was surprising to see how proteins that normally act as ‘gatekeepers’ to the nucleus instead become active participants in the virus’s replication machinery,” says the first author.
The studies show that NUP98 and NUP153 have distinct roles during infection. NUP98 is required for efficient replication of viral RNA, while NUP153 influences how much of the different viral proteins are produced.
NUP153 binds to a specific region of the viral RNA located between the sequences encoding structural and non-structural proteins. Through this interaction, the balance between different viral proteins is regulated, which is critical at an early stage of infection. sciencenewshighlights ScienceMission.
Gravitational Constant’s Value Still Up in the Air
Researchers repeated a key measurement of the fundamental constant G, but the results remain inconsistent, highlighting the difficulty of putting gravity on the proverbial scale.
Full Metal Gear Solid 2 source code leaks online on 30th April
The full source code for Metal Gear Solid 2: Sons of Liberty has leaked online.
The files, posted to 4chan, reportedly include the raw, uncompressed source code for “every version up to [the PS] Vita”, as well as “30+GB of assets, including unused stuff”
Scientists Unveil ‘Long Lost’ Map for Smell
The odor receptors in the nose are not distributed at random but organized in a precise spatial pattern, two new studies reveal.
Warcraft 3 Legacy is finally back on Battle.net
And you don’t have to install Warcraft 3 Reforged to launch it.
Beyond Inflammation: Scientists Uncover New Cause of Persistent Rheumatoid Arthritis
Scar-driven changes in joint tissue may underlie treatment resistance in rheumatoid arthritis, opening the door to new targeted therapies.
An intrinsically disordered tug of war that fine-tunes acetylation
Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al. have shown how intrinsically disordered regions of CBP temper each other to shape acetyltransferase activity.