To help reduce this problem, Evitria says they’ve licensed Lonza’s bYlok^® technology to improve light chain pairing. The starting point involves antibodies with a “knob” or a “hole” in the heavy chains, so-called “knobs-into-holes” technology, to help improve correct bonding between parts of the bispecific, Schmidt explained.

“What you have are two variations, bYlok and non-loked, and another two combinations where one chain has a hole formation and the other a knob formation and vice versa,” he says. “And you can express these four combinations to see the impact of the expression level, the yields, heterodimer formation, and purity.”

By doing this early screening, he adds, it’s possible for customers to speed up their process development and move to commercial bsAb manufacturing.

Bifurcation parameter is a root point of period-2ⁿ component. This series converges to the Feigenbaum point c = −1.401155… The ratio in the last column converges to the first Feigenbaum constant.

“Lake Enigma” is living up to its name.

By measuring the melting temperature of iron under high transient pressure, researchers set a limit on the temperature at the boundary between the inner and outer cores.

Diving deep into the relationship between a concept’s frequency in the training dataset and the ability of a model to imitate it. We seek to determine the point at which a model was trained on enough instances to imitate a concept — the imitation threshold.

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Exploring the potential of glycomimetic peptides as powerful anti-inflammatory therapeutic treatments.