JUST PUBLISHED: oxygen permeable dextran nanogels as a hemoglobin-based oxygen carrier
Click here to read the latest free, Open Access article from Biomaterials Research.
JUST PUBLISHED: oxygen permeable dextran nanogels as a hemoglobin-based oxygen carrier
Click here to read the latest free, Open Access article from Biomaterials Research.
A new psychological study finds that people with high levels of psychopathy and Machiavellianism are more likely to approach romance with hostility and use coercive tactics in the bedroom.
Apache fixes CVE-2026–23918 in HTTP/2; double-free flaw enables DoS and RCE, impacting version 2.4.66 users.
Scientists discover human heart can regrow muscle cells after heart attack, opening path to regenerative therapies.
NOAA measures a giant Mariana Islands megacoral that may be over 2,000 years old in a stunning undersea volcano setting.
The metabolite citraconate can preserve T cell stemness and suppress exhaustion, promoting antitumor immunity and responses to immunotherapies in mice.
Learn more in Science Immunology.
Sci. Immunol. 11, eadz0348 (2026). DOI:10.1126/sciimmunol.adz0348
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In two recently published studies, the nucleoporins NUP98 and NUP153 have been identified as key host factors in orthoflavivirus infection.
NUP98 and NUP153 are normally part of the nuclear pore complex, which regulates the transport of proteins and RNA between the cell nucleus and the cytosol, the fluid in which the cell’s internal components are suspended. Since orthoflaviviruses copy their RNA in the cytosol, these proteins had not previously been linked to the viral life cycle.
The researchers now show that during infection, both nucleoporins are recruited to viral replication sites in the cytosol, where they bind directly to viral RNA. In addition, NUP153 also interacts with viral proteins.
“It was surprising to see how proteins that normally act as ‘gatekeepers’ to the nucleus instead become active participants in the virus’s replication machinery,” says the first author.
The studies show that NUP98 and NUP153 have distinct roles during infection. NUP98 is required for efficient replication of viral RNA, while NUP153 influences how much of the different viral proteins are produced.
NUP153 binds to a specific region of the viral RNA located between the sequences encoding structural and non-structural proteins. Through this interaction, the balance between different viral proteins is regulated, which is critical at an early stage of infection. sciencenewshighlights ScienceMission.
Researchers repeated a key measurement of the fundamental constant G, but the results remain inconsistent, highlighting the difficulty of putting gravity on the proverbial scale.
The full source code for Metal Gear Solid 2: Sons of Liberty has leaked online.
The files, posted to 4chan, reportedly include the raw, uncompressed source code for “every version up to [the PS] Vita”, as well as “30+GB of assets, including unused stuff”
The odor receptors in the nose are not distributed at random but organized in a precise spatial pattern, two new studies reveal.