Hunter-gatherers in southern Africa laced their stone arrow tips with poison roughly 60,000 years ago, a new Science Advances study finds.
The discovery pushes back the timeline for poison weapon use from the mid-Holocene to the Late Pleistocene.
Earliest proof of plant poisons on arrows reveals complex Pleistocene hunting in southern Africa.
Loss of lipin1 disrupts heart muscle membrane integrity, driving inflammation, fibrosis, and contributing to heart failure.
BackgroundLipin1 has dual functions acting as phosphatidic acid phosphatase required for lipid synthesis and as a transcriptional coactivator. Our previous research demonstrated that lipin1 is critical for maintaining sarcolemmal integrity in skeletal muscle. Given the importance of sarcolemmal stability for cardiac muscle viability and function, we investigated the role of lipin1 in the heart using a novel cardiac‐specific lipin1 deficient (Myh6‐lipin 1−/−) mouse model.
Liquids and solutions may look simple, but on the molecular scale they are constantly shifting and reorganizing. When sugar dissolves in water, each sugar molecule quickly becomes surrounded by fast moving water molecules. Inside living cells, the situation is even more intricate. Tiny liquid drople
One of nature’s most familiar forces might be doing something far stranger than we ever imagined.
The jsPDF library for generating PDF documents in JavaScript applications is vulnerable to a critical vulnerability that allows an attacker to steal sensitive data from the local filesystem by including it in generated files.
The flaw is a local file inclusion and path traversal that allows passing unsanitized paths to the file loading mechanism (loadFile) in jsPDF versions before 4.0. It is tracked as CVE-2025–68428 and received a severity score of 9.2.
The jsPDF library is a widely adopted package with more than 3.5 million weekly downloads in the npm registry.
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