Acute ischemic stroke is a complex disorder in which the damage goes beyond neuronal loss and involves dynamic responses from glial, vascular, stromal, and immune cells. Spatial transcriptomics (ST) has become a powerful tool to study these processes by preserving tissue architecture while revealing detailed gene expression patterns. This review describes how ST has advanced the understanding of cellular changes after stroke, focusing on microglia, astrocytes, and oligodendrocytes to showcase the complexity of stroke pathobiology.

Microsoft is rolling out Windows Update improvements that give users more control over how updates are installed while reducing disruption from frequent or poorly timed restarts.

The company says the improvements are now rolling out to Windows Insiders, following user feedback that highlighted two key issues: updates are disrupting workflows, and there is a lack of control over when they are installed.

“We are continually reading the feedback submitted about the Windows update experience. Personally, I’ve had the opportunity to read over 7,621 direct verbatims over the last few months,” explains Microsoft’s Aria Hanson.

In a cohort study comparing high-risk definitions for smoldering multiple myeloma (#SMM), the AQUILA trial criteria was assessed against the 2/20/20 risk model.

The AQUILA criteria classified approximately 3 times more individuals as high-risk versus the 2/20/20 model, but included a substantial group with lower progression risk.

The 2/20/20 model more precisely identified a smaller group of individuals with higher risk of progression, supporting its use to target early intervention for those most likely to benefit.

This cohort study compares the AQUILA trial inclusion criteria and the 2/20/20 risk stratification model definitions for identifying individuals with smoldering multiple myeloma at high risk of progression.

RetroRender will bring back the golden age of pixels in Unity.

Theorists have identified a phase that could facilitate the switching of a crystal between its right-handed and left-handed versions.

Apple fixes CVE-2026–28950 in iOS 26.4.2 after deleted notifications were retained, mitigating forensic data exposure.

The current model of necroptosis assumes that MLKL’s N-terminal cytotoxic domain is unleashed from autoinhibition concurrent with phosphorylation by RIPK3. Here, Pan and Abbott show that inhibition of MLKL’s N terminus abolishes phosphorylation by RIPK3 whereas removal or relieving autoinhibition between the N-terminal and intermediate domains promotes its phosphorylation.

A new model reveals that two very different laser pulse behaviors are fundamentally connected.