A new geological study reshapes the timeline of a major tectonic collision that helped form the Andes, suggesting key events occurred earlier than long assumed.

Microplastics circulate globally through the atmosphere, but their sources may not be what scientists once thought.

Gallium has revealed unexpected behavior that challenges decades-old assumptions about its liquid structure.

Two Composer flaws (CVE-2026–40176, CVE-2026–40261) allow command execution via Perforce configurations, prompting urgent updates.

Huang et al. identify Scap as a key regulator of macrophage anti-fungal immunity that stabilizes PKM2 and sustains glycolysis independently of SREBP-mediated lipid synthesis, thereby establishing a Scap-PKM2 axis essential for cytokine production, phagocytosis, and fungal control.

Wang, W., Liu, X., Liu, H. et al. p53: from understanding its structure to advances in therapeutic targeting. Sig Transduct Target Ther 11, 121 (2026). https://doi.org/10.1038/s41392-025-02549-5

Download citation.

A coat of sialylated protein protects human leukemia cells from destruction.

Learn more in a new Science Perspective.

---

Stefania Canè and Vincenzo Bronte Authors Info & Affiliations

Science.

Now online! Rational design of cannabinoid receptor agonists that uncouple therapeutic analgesia from unwanted on-target effects, establishing a blueprint for next-generation non-opioid therapeutics.

Satellite observations reveal that global nighttime lighting is steadily rising, though the trend varies widely by region, with some areas brightening rapidly while others dim.