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NPL, in collaboration with London Biofoundry and BiologIC Technologies Ltd, have released an analysis on existing and emerging DNA Synthesis technologies in Nature Reviews Chemistry, featuring the work on the front cover.

The study, which was initiated by DSTL, set out to understand the development trajectory of DNA Synthesis as a major industry drive for the UK economy over the next 10 years. The demand for synthetic DNA is growing exponentially. However, our ability to make, or write, DNA lags behind our ability to sequence, or read, it. The study reviewed existing and emerging DNA synthesis technologies developed to close this gene writing gap.

DNA or genes provide a universal tool to engineer and manipulate living systems. Recent progress in DNA synthesis has brought up limitless possibilities in a variety of industry sectors. Engineering biology, therapy and diagnostics, , defense and nanotechnology are all set for unprecedented breakthroughs if DNA can be provided at scale and low cost.

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Summary: Researchers have developed a more powerful and energy-efficient memristor, based on the structure of the human brain, that combines data storage and processing. The new technology, made from nanocrystals of halogenated perovskite, is not yet ready for use as it is difficult to integrate with existing computer chips, but it has the potential for parallel processing of large amounts of data.

Source: Politecnico di Milano.

Inspired by the brain’s energy efficiency, copying its structure to create more powerful computers, a team of researchers from Politecnico di Milano, Empa and ETH Zurich has developed a memristor that is more powerful and easier to produce than its predecessors: the results have been published in Science Advances.

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Year 2014 face_with_colon_three If black holes have infinitely small sizes and infinitely density this also means that string theory would also solve the infinitely small problem because now we know that infinitely small sizes exist and if that exists then so does infinite energy from super string essentially filling out the rest of the mystery of the God equation. This means that computers could be infinitely small aswell saving a ton of space aswell.

If you’ve wondered how big is a black hole? then you’ve come to the right place! Learn about the sizes of black holes and the multi-layered answer.

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Published in the journal Quantum Science and Technology, Saleh’s research focused on a novel quantum computing technique that should — at least on paper — be able to reconstitute a small object across space “without any particles crossing.”

While it’s an exciting prospect, realizing his vision will require a lot more time and effort — not to mention next-generation quantum computers that haven’t been designed, let alone built yet. That is if it’s even possible at all.

Counterportation can be achieved, the study suggests, by the construction of a small “local wormhole” in a lab — and as the press release notes, plans are already underway to actually build the groundbreaking technology described in the paper.

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Driving Toward the Elimination of Cancer — Joel Greshock — VP, Oncology, Data Science & Digital Health, Janssen Pharmaceutical Companies of Johnson & Johnson.

Joel Greshock is VP, Oncology, Data Science & Digital Health, Janssen Research & Development (https://www.janssen.com/oncology/leadership-team). In this position, he is responsible for creating unique and actionable medical insights using large and increasingly available datasets. The focus of this research includes discovering novel therapeutic targets, identifying areas of unmet medical need, and enhancing clinical trial recruitment and execution.

Prior to joining Janssen R&D, Joel served as Vice President of Bioinformatics at Neon Therapeutics, Inc., where he built and managed the Data Sciences organization. At Neon, he was responsible for the design and deployment of personalized cancer therapies now under clinical evaluation.

Prior to joining Neon, Joel served as Head of Oncology Translational Informatics for Novartis, where he was responsible for the correlation of patient outcomes with molecular biomarkers, identification of mechanisms of clinical resistance and computational research for assets approaching or being evaluated in early phases of development.

Before joining Novartis, Joel assumed numerous roles for GlaxoSmithKline Oncology, which included Head of Bioinformatics. Earlier in his career, Joel was a Data Analyst at Abramson Family Cancer Research Institute at the University of Pennsylvania, where he built early generation microarray platforms and developed widely used predictive models for cancer predisposition mutations.

Continue reading “Joel Greshock — VP, Oncology, Data Science & Digital Health — Janssen Research & Development” | >

This post is also available in: he עברית (Hebrew)

According to a report done by Surfshark VPN, out of the approximately 5 billion of internet users, over 1.6 billion of them (31% of users) use a VPN. That’s close to a fifth of the worlds population.

A VPN, or a Virtual Private Network, is a mechanism for creating a secure connection between a computing device and a computer network, or between two networks, using an insecure communication medium such as the public Internet. A VPN can extend a private network (one that disallows or restricts public access), enabling users to send and receive data across public networks as if their devices were directly connected to the private network.

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Shortform link:
https://shortform.com/artem.

In this video we will explore a very interesting paper published in Nature in 2022, which describes the hidden torus in the neuronal activity of cells in the entorhinal cortex, known as grid cells.

Place cell video: https://www.youtube.com/watch?v=iV-EMA5g288&t=158s.

Neural manifolds video: https://www.youtube.com/watch?v=QHj9uVmwA_0

My name is Artem, I’m a computational neuroscience student and researcher.
Socials:
Twitter: https://twitter.com/ArtemKRSV

REFERENCES:

Continue reading “Your brain is moving along the surface of the torus 🤯” | >

Shortform link:
https://shortform.com/artem.

My name is Artem, I’m a computational neuroscience student and researcher.

In this video we will talk about the fundamental role of lognormal distribution in neuroscience. First, we will derive it through Central Limit Theorem, and then explore how it support brain operations on many scales — from cells to perception.

REFERENCES:

1. Buzsáki, G. & Mizuseki, K. The log-dynamic brain: how skewed distributions affect network operations. Nat Rev Neurosci 15264–278 (2014).
2. Ikegaya, Y. et al. Interpyramid Spike Transmission Stabilizes the Sparseness of Recurrent Network Activity. Cerebral Cortex 23293–304 (2013).
3. Loewenstein, Y., Kuras, A. & Rumpel, S. Multiplicative Dynamics Underlie the Emergence of the Log-Normal Distribution of Spine Sizes in the Neocortex In Vivo. Journal of Neuroscience 31, 9481–9488 (2011).
4. Morales-Gregorio, A., van Meegen, A. & van Albada, S. J. Ubiquitous lognormal distribution of neuron densities across mammalian cerebral cortex. http://biorxiv.org/lookup/doi/10.1101/2022.03.17.480842 (2022) doi:10.1101/2022.03.17.480842.

OUTLINE:

Continue reading “Logarithmic nature of the brain 💡” | >

Head to https://linode.com/scishow to get a $100 60-day credit on a new Linode account. Linode offers simple, affordable, and accessible Linux cloud solutions and services.

Scientists like to measure things, but they’ve had a heck of a time doing that with sharpness. And even if no one agrees on exactly how to measure it, our search for better tools has recently led to some of the sharpest objects we’ve ever created.

Hosted by: Hank Green (he/him)
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scienceofsharp


https://www.sciencedirect.com/science/article/pii/S0924013604007022
https://www.sciencedirect.com/science/article/pii/S0013794406004073
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https://link.springer.com/content/pdf/10.1007/s10816-022…;0.pdf?pdf.

Images:
https://commons.wikimedia.org/wiki/File: Crater_knife_edge.jpg.

Dual Grit Sharpening


https://www.researchgate.net/figure/Artificial-sapphire-scal…_354874023
https://www.southampton.ac.uk/biu/galleries/sem.page.
https://commons.wikimedia.org/wiki/File: Obsidian_blade_mounted_in_ornamental_handle,_from_Admiralty_Wellcome_M0015133.jpg.
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https://commons.wikimedia.org/wiki/File:Prehistoric_Denmark_…51010).jpg

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The breakthrough experiment could lead to low-energy, wave-based computers and new applications for wireless communications.

Researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) performed a breakthrough experiment in which they observed time reflections of electromagnetic signals in a tailored metamaterial.

Time reflection versus spatial reflection.

Andrea Alu.

The scientists, who published their findings in a paper in Nature Physics, were able to successfully cause time reversal as well as frequency conversion of broadband electromagnetic waves in their experiments.

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