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Category: chemistry – Page 48

A silent symphony is playing inside your brain right now as neurological pathways synchronize in an electromagnetic chorus that’s thought to give rise to consciousness.

Yet how various circuits throughout the brain align their firing is an enduring mystery, one some theorists suggest might have a solution that involves quantum entanglement.

The proposal is a bold one, not least because quantum effects tend to blur into irrelevance on scales larger than atoms and molecules. Several recent findings are forcing researchers to put their doubts on hold and reconsider whether quantum chemistry might be at work inside our minds after all.

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A new publication has discovered ways to reduce the toxicity of graphene oxide (GO), an ultra-thin sheet of nanomaterial derived from graphite, laying the groundwork to use it as a drug delivery system.

Professor Khuloud Al-Jamal, who led the study, said: “Researchers have been incredibly excited in the potential medical applications of graphene since experiments into the nanomaterial were recognised with the Nobel Prize in Physics in 2010. However, concerns around toxicity have remained a consistent obstacle.”

Graphene oxide (GO) is an ultra-thin sheet derived from graphite. It is similar to pencil lead but includes attached oxygen atoms, making it compatible with water. Its unique physical and chemical properties mean it has a high capacity for carrying antibiotics and anticancer drugs, among others, as well as targeting specific cells, making it a potentially effective drug delivery system.

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Nanomaterials, with their distinctive physical and chemical properties, hold significant promise for revolutionizing the housing construction industry. By enabling the development of stronger, more durable, efficient, and sustainable structures, nanotechnology offers solutions to challenges such as climate change and global urbanization.

The use of nanomaterials in construction began in the mid-1980s with the advent of carbon-based structures. Since then, their application has become more widespread, driving innovations in the sector. Today, advances in nanotechnology are leading to the creation of increasingly sophisticated, selective, and efficient nanomaterials, broadening the scope of construction capabilities.

This study explored the application of various nanomaterials—titanium dioxide, carbon nanotubes (CNTs), nanosilica, nanocellulose, nanoalumina, and nanoclay—in residential construction. These materials were chosen for their potential to enhance the structural integrity, thermal performance, and overall functionality of building materials used in housing.

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The Driving Training Based Optimization (DTBO) algorithm, proposed by Mohammad Dehghani, is one of the novel metaheuristic algorithms which appeared in 202280. This algorithm is founded on the principle of learning to drive, which unfolds in three phases: selecting an instructor from the learners, receiving instructions from the instructor on driving techniques, and practicing newly learned techniques from the learner to enhance one’s driving abilities81,82. In this work, DTBO algorithm is used, due to its effectiveness, which was confirmed by a comparative study83 with other algorithms, including particle swarm optimization84, Gravitational Search Algorithm (GSA)85, teaching learning-based optimization, Gray Wolf Optimization (GWO)86, Whale Optimization Algorithm (WOA)87, and Reptile Search Algorithm (RSA)88. The comparative study has been done using various kinds of benchmark functions, such as constrained, nonlinear and non-convex functions.

Lyapunov-based Model Predictive Control (LMPC) is a control approach integrating Lyapunov function as constraint in the optimization problem of MPC89,90. This technique characterizes the region of the closed-loop stability, which makes it possible to define the operating conditions that maintain the system stability91,92. Since its appearance, the LMPC method has been utilized extensively for controlling a various nonlinear systems, such as robotic systems93, electrical systems94, chemical processes95, and wind power generation systems90. In contrast to the LMPC, both the regular MPC and the NMPC lack explicit stability restrictions and can’t combine stability guarantees with interpretability, even with their increased flexibility.

The proposed method, named Lyapunov-based neural network model predictive control using metaheuristic optimization approach (LNNMPC-MOA), includes Lyapunov-based constraint in the optimization problem of the neural network model predictive control (NNMPC), which is solved by the DTBO algorithm. The suggested controller consists of two parts: the first is responsible for calculating predictions using a neural network model of the feedforward type, and the second is responsible to resolve the constrained nonlinear optimization problem using the DTBO algorithm. This technique is suggested to solve the nonlinear and non-convex optimization problem of the conventional NMPC, ensure on-line optimization in reasonable time thanks to their easy implementation and guaranty the stability using the Lyapunov function-based constraint. The efficiency of the proposed controller regarding to the accuracy, quickness and robustness is assessed by taking into account the speed control of a three-phase induction motor, and its stability is mathematically ensured using the Lyapunov function-based constraint. The acquired results are compared to those of NNMPC based on DTBO algorithm (NNMPC-DTBO), NNMPC using PSO algorithm (NNMPC-PSO), Fuzzy Logic controller optimized by TLBO (FLC-TLBO) and optimized PID controller using PSO algorithm (PID-PSO)95.

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Jim Clarke, Director of Quantum Hardware at Intel Labs, discusses how chemistry and physics drive the development of qubits in these unique systems. These systems will bring mind-blowing computing power to the world in the next decade and beyond.

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Inventing a new, faster way to produce sustainable, self-dyed leather alternatives is a major achievement for synthetic biology and sustainable fashion. Professor Tom Ellis

Synthetic chemical dyeing is one of the most environmentally toxic processes in fashion, and black dyes – especially those used in colouring leather – are particularly harmful. The researchers at Imperial set out to use biology to solve this.

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Researchers at the University of Maryland genetically modified poplar trees to produce high-performance, structural wood without the use of chemicals or energy-intensive processing. Made from traditional wood, engineered wood is often seen as a renewable replacement for traditional building materials like steel, cement, glass and plastic. It also has the potential to store carbon for a longer time than traditional wood because it can resist deterioration, making it useful in efforts to reduce carbon emissions.

But the hurdle to true sustainability in engineered wood is that it requires processing with volatile chemicals and a significant amount of energy, and produces considerable waste. The researchers edited one gene in live poplar trees, which then grew wood ready for engineering without processing.

The research was published online on August 12, 2024, in the Journal Matter.

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For decades, microbiologists like Weiss thought of antibiotic resistance as something a bacterial species either had or didn’t have. But “now, we are realizing that that’s not always the case,” he said.

Normally, genes determine how bacteria resist certain antibiotics. For example, bacteria could gain a gene mutation that enables them to chemically disable antibiotics. In other cases, genes may code for proteins that prevent the drugs from crossing bacterial cell walls. But that is not the case for heteroresistant bacteria; they defeat drugs designed to kill them without bona fide resistance genes. When they’re not exposed to an antibiotic, these bacteria look like any other bacteria.

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Leading The Next Wave Of Innovation In Drug Discovery, To Modulate Any Target, Every Time — Dr. P. Ryan Potts, Ph.D., VP and Head, Induced Proximity Platform, Amgen.

Dr. Ryan Potts, Ph.D. is Vice President and Head, Induced Proximity Platform at Amgen (https://www.amgen.com/science/researc…) which is focused on novel ways to bring two or more molecules in close proximity to each other to tackle drug targets that are currently considered “undruggable.” He also leads Amgen’s Research \& Development Postdoctoral Fellows Program (https://www.amgen.com/science/scienti…).

Dr. Potts obtained his B.S. in Biology from the University of North Carolina and his Ph.D. in Cell and Molecular Biology from UT Southwestern in 2007. In 2008 he was awarded the Sara and Frank McKnight junior faculty position at UT Southwestern Medical Center. During this time his lab focused on answering a long-standing question in cancer biology regarding the cellular function of cancer-testis antigen (CTAs) proteins. In 2011 he was appointed Assistant Professor in the Departments of Physiology, Pharmacology, and Biochemistry at UT Southwestern Medical Center. His lab’s work defined a function for the enigmatic MAGE gene (Melanoma Antigen Gene) family in protein regulation through ubiquitination.

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