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The groups also explained why in previous studies by other scientists, the chromatin appeared to fill the cell nuclei. “When scientists plate cells on a glass slide in order to study them under a microscope, they change their volume and physically flatten them. This may perturb some of the forces governing chromatin arrangement and reduce the distance between the upper part of the nucleus to its base,” Safran explains.


If you open a biology textbook and run through the images depicting how DNA is organized in the cell’s nucleus, chances are you’ll start feeling hungry; the chains of DNA would seem like a bowl of ramen: long strings floating in liquid. However, according to two new studies—one experimental and the other theoretical—that are the outcome of the collaboration between the groups of Prof. Talila Volk of the Molecular Genetics Department and Prof. Sam Safran of the Chemical and Biological Physics Department at the Weizmann Institute of Science, this image should be reconsidered. Clarifying it is essential since DNA’s spatial arrangement in the nucleus can affect the expression of genes contained within the DNA molecule, and hence the proteins found in the cell.

This story began when Volk was studying how mechanical forces influence cell nuclei in the muscle and found evidence that muscle contractions had an immediate effect on gene expression patterns. “We couldn’t explore this further because existing methods relied on imaging of chemically preserved cells, so they failed to capture what happens in the cell nuclei of an actual working muscle,” she says.

To address this issue, Dr. Dana Lorber, a research associate in Volk’s group, led the design of a device that makes it possible to study muscle nuclei in live fruit fly larvae. The device holds the tiny, translucent larva within a groove that allows it to contract and relax its muscles but keeps its movement constrained so that it can be scanned by a fluorescence microscope. Using the device, the researchers obtained images of the internal, linearly-organized complexes of DNA and its proteins (known as chromatin), surrounded by the membrane of the muscle nuclei.

A more general definition of entropy was proposed by Boltzmann (1877) as S = k ln W, where k is Boltzmann’s constant, and W is the number of possible states of a system, in the units J⋅K−1, tying entropy to statistical mechanics. Szilard (1929) suggested that entropy is fundamentally a measure of the information content of a system. Shannon (1948) defined informational entropy as \(S=-\sum_{i}{p}_{i}{log}_{b}{p}_{i}\) where pi is the probability of finding message number i in the defined message space, and b is the base of the logarithm used (typically 2 resulting in units of bits). Landauer (1961) proposed that informational entropy is interconvertible with thermodynamic entropy such that for a computational operation in which 1 bit of information is erased, the amount of thermodynamic entropy generated is at least k ln 2. This prediction has been recently experimentally verified in several independent studies (Bérut et al. 2012; Jun et al. 2014; Hong et al. 2016; Gaudenzi et al. 2018).

The equivalency of thermodynamic and informational entropy suggests that critical points of instability and subsequent self-organization observed in thermodynamic systems may be observable in computational systems as well. Indeed, this agrees with observations in cellular automata (e.g., Langton 1986; 1990) and neural networks (e.g., Wang et al. 1990; Inoue and Kashima 1994), which self-organize to maximize informational entropy production (e.g., Solé and Miramontes 1995). The source of additional information used for self-organization has been identified as bifurcation and deterministic chaos (Langton 1990; Inoue and Kashima 1994; Solé and Miramontes 1995; Bahi et al. 2012) as defined by Devaney (1986). This may provide an explanation for the phenomenon termed emergence, known since classical antiquity (Aristotle, c. 330 BCE) but lacking a satisfactory explanation (refer to Appendix A for discussion on deterministic chaos, and Appendix B for discussion on emergence). It is also in full agreement with extensive observations of deterministic chaos in chemical (e.g., Nicolis 1990; Györgyi and Field 1992), physical (e.g., Maurer and Libchaber 1979; Mandelbrot 1983; Shaw 1984; Barnsley et al. 1988) and biological (e.g., May 1975; Chay et al. 1995; Jia et al. 2012) dissipative structures and systems.

This theoretical framework establishes a deep fundamental connection between cyberneticFootnote 1 and biological systems, and implicitly predicts that as more work is put into cybernetic systems composed of hierarchical dissipative structures, their complexity increases, allowing for more possibilities of coupled feedback and emergence at increasingly higher levels. Such high-level self-organization is routinely exploited in machine learning, where artificial neural networks (ANNs) self-organize in response to inputs from the environment similarly to neurons in the brain (e.g., Lake et al. 2017; Fong et al. 2018). The recent development of a highly organized (low entropy) immutable information carrier, in conjunction with ANN-based artificial intelligence (AI) and distributed computing systems, presents new possibilities for self-organization and emergence.

High-energy cosmic rays have proven elusive… but we may have found their source.


Thanks to new research led by the University of Nagoya, scientists have quantified the number of cosmic rays produced in a supernova remnant for the first time. This research has helped resolve a 100-year mystery and is a major step towards determining precisely where cosmic rays come from.

While scientists theorize that cosmic rays originate from many sources — our Sun, supernovae, gamma-ray bursts (GRBs), and active galactic nuclei (sometimes called quasars) — their exact origin has been a mystery since they were first discovered in 1912. Similarly, astronomers have theorized that supernova remnants (the after-effects of supernova explosions) are responsible for accelerating them to nearly the speed of light.

As they travel through our galaxy, cosmic rays play a role in the chemical evolution of the interstellar medium (ISM). As such, understanding their origin is critical to understanding how galaxies evolve.

Earlier this year, researchers found a deposit of rare-earth minerals off the coast of Japan that could supply the world for centuries, according to a study.

The study, published in the journal Nature in April 2,018 says the deposit contains 16 million tons of the valuable metals.

Rare-earth minerals are used in everything from smartphone batteries to electric vehicles. By definition, these minerals contain one or more of 17 metallic rare-earth elements (for those familiar with the periodic table, those are on the second row from the bottom).

These elements are actually plentiful in layers of the Earth’s crust, but are typically widely dispersed. Because of that, it is rare to find any substantial amount of the elements clumped together as extractable minerals, according to the USGS.

Dr. The book launch will happen on September 4th, at 3 p.m. (Pacific Time) in Book Passage Ferry Building Store in San Francisco, California!
Please come to have an in-person chat with Dr. Katcher.

Dr. Harold Katcher is one of the discoverers of the human breast cancer gene (BRCA1), and has thousands of citations in the scientific literature, with publications ranging from protein structure to bacteriology, biotechnology, bioinformatics and biochemistry. He was the Academic Director for Natural Sciences for the Asian Division of the University of Maryland Global Campus, and nowadays is Chief Scientific Officer at Yuvan Research Inc., which is working on the development of rejuvenation treatments.

https://www.bookpassage.com/event/harold-katcher-illusion-kn…ding-store.
https://www.ntzplural.com/harold-katcher-launches-book.
https://www.facebook.com/events/553354852782737?ref=newsfeed.

#haroldkatcher #sanfrancisco #california #booklaunch #biotechnology #rejuvenation #aging.

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The device offers a far simpler way of monitoring how various chemical compounds form during reactions than the methods currently available to scientists, and the team that built the “camera” says it’s already using it to improve the technology behind solar cells.

Controlling the specific order and process of molecular assembly is notoriously difficult, especially at such tiny scales. Thankfully, the scientists realized that they merely had to plunk its components into room-temperature water — along with whatever molecules they wanted to study — and it would piece itself together automatically.

“We were surprised how powerful this new tool is, considering how straightforward it is to assemble,” first study author and Cambridge chemist Kamil Sokolowski said in a press release.

University of Houston researchers are reporting a breakthrough in the field of materials science and engineering with the development of an electrochemical actuator that uses specialized organic semiconductor nanotubes (OSNTs).

Currently in the early stages of development, the actuator will become a key part of research contributing to the future of robotic, bioelectronic and .

“Electrochemical devices that transform to mechanical energy have potential use in numerous applications, ranging from soft robotics and micropumps to autofocus microlenses and bioelectronics,” said Mohammad Reza Abidian, associate professor of biomedical engineering in the UH Cullen College of Engineering. He’s the corresponding author of the article “Organic Semiconductor Nanotubes for Electrochemical Devices,” published in the journal Advanced Functional Materials, which details the discovery.

Researchers have made a tiny camera, held together with ‘molecular glue’ that allows them to observe chemical reactions in real time.

The device, made by a team from the University of Cambridge, combines tiny semiconductor nanocrystals called and gold nanoparticles using molecular glue called cucurbituril (CB). When added to water with the molecule to be studied, the components self-assemble in seconds into a stable, powerful tool that allows the real-time monitoring of chemical reactions.

The camera harvests light within the semiconductors, inducing electron transfer processes like those that occur in photosynthesis, which can be monitored using incorporated gold nanoparticle sensors and spectroscopic techniques. They were able to use the camera to observe which had been previously theorized but not directly observed.

In a new review article in Nature Photonics, scientists from Los Alamos National Laboratory assess the status of research into colloidal quantum dot lasers with a focus on prospective electrically pumped devices, or laser diodes. The review analyzes the challenges for realizing lasing with electrical excitation, discusses approaches to overcome them, and surveys recent advances toward this objective.

“Colloidal quantum dot lasers have tremendous potential in a range of applications, including integrated optical circuits, wearable technologies, lab-on-a-chip devices, and advanced medical imaging and diagnostics,” said Victor Klimov, a senior researcher in the Chemistry division at Los Alamos and lead author of the cover article in Nature Photonics. “These solution-processed quantum dot present unique challenges, which we’re making good progress in overcoming.”

Heeyoung Jung and Namyoung Ahn, also of Los Alamos’ Chemistry division, are coauthors.

The chernobyl special industrial zone — ecosystem restoration, remediation, and the development of energy and chemical byproducts — mykola tolmachov, chernobyl-51 industrial cluster.


The Chernobyl disaster / nuclear accident, occurred on April 26th, 1,986 at the No. 4 reactor in the Chernobyl Nuclear Power Plant, near the city of Pripyat in the north of Ukraine.

The initial emergency response, together with later decontamination of the environment, ultimately involved more than 500,000 personnel and cost an estimated US$68 billion, adjusted for inflation.

The current Chernobyl Exclusion Zone covers an area of approximately 2,600 km2 (1,000 sq mi) in Ukraine, immediately surrounding the Chernobyl Nuclear Power Plant, where radioactive contamination is highest and public access and inhabitation are restricted.

The Exclusion Zone’s purpose is to restrict access to hazardous areas, reduce the further spread of radiological contamination, and conduct radiological and ecological monitoring activities.