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Category: chemistry – Page 284

The University of Surrey has built an artificial intelligence (AI) model that identifies chemical compounds that promote healthy aging — paving the way towards pharmaceutical innovations that extend a person’s lifespan.

In a paper published by Nature Communication’s Scientific Reports, a team of chemists from Surrey built a machine learning model based on the information from the DrugAge database to predict whether a compound can extend the life of Caenorhabditis elegans — a translucent worm that shares a similar metabolism to humans. The worm’s shorter lifespan gave the researchers the opportunity to see the impact of the chemical compounds.

The AI singled out three compounds that have an 80 percent chance of increasing the lifespan of elegans:

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A new tool that enables thousands of tiny experiments to run simultaneously on a single polymer chip will let scientists study enzymes faster and more comprehensively than ever before.

For much of human history, animals and plants were perceived to follow a different set of rules than rest of the universe. In the 18th and 19th centuries, this culminated in a belief that living organisms were infused by a non-physical energy or “life force” that allowed them to perform remarkable transformations that couldn’t be explained by conventional chemistry or physics alone.

Scientists now understand that these transformations are powered by enzymes – protein molecules comprised of chains of amino acids that act to speed up, or catalyze, the conversion of one kind of molecule (substrates) into another (products). In so doing, they enable reactions such as digestion and fermentation – and all of the chemical events that happen in every one of our cells – that, left alone, would happen extraordinarily slowly.

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For decades, researchers around the world have searched for ways to use solar power to generate the key reaction for producing hydrogen as a clean energy source—splitting water molecules to form hydrogen and oxygen. However, such efforts have mostly failed because doing it well was too costly, and trying to do it at a low cost led to poor performance.

Now, researchers from The University of Texas at Austin have found a low-cost way to solve one half of the equation, using sunlight to efficiently split off oxygen molecules from water. The finding, published recently in Nature Communications, represents a step forward toward greater adoption of hydrogen as a key part of our energy infrastructure.

As early as the 1970s, researchers were investigating the possibility of using solar energy to generate hydrogen. But the inability to find materials with the combination of properties needed for a device that can perform the key chemical reactions efficiently has kept it from becoming a mainstream method.

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The findings, published in Nature Communications, could have important implications for human health: minis have been found at every type of synapse studied so far, and defects in miniature neurotransmission have been linked to range of neurodevelopmental disorders in children. Figuring out how a reduction in miniature neurotransmission changes the structure of synapses, and how that in turn affects behavior, could help to better understand neurodegenerative disorders and other brain conditions.

Summary: Study reveals how miniature release events help to keep neurons intact and preserve motor neuron function in aging insects.

Source: EPFL

Neurons communicate through rapid electrical signals that regulate the release of neurotransmitters, the brain’s chemical messengers. Once transmitted across a neuron, electrical signals cause the juncture with another neuron, known as a synapse, to release droplets filled with neurotransmitters that pass the information on to the next neuron. This type of neuron-to-neuron communication is known as evoked neurotransmission.

However, some neurotransmitter-packed droplets are released at the synapse even in the absence of electrical impulses. These miniature release events — or minis — have long been regarded as ‘background noise’, says Brian McCabe, Director of the Laboratory of Neural Genetics and Disease and a Professor in the EPFL Brain Mind Institute.

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Summary: Newly synthesized compounds can halt the degradation of neurons in a range of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, researchers say.

Source: Ural Federal University

Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer’s, Parkinson’s, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies.

New molecules of pyrrolyl-and indolylazine classes activate intracellular mechanisms to combat one of the main causes of “aged” brain diseases – an excess of so-called amyloid structures that accumulate in the human brain with age.

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Chemical engineer Zhenan Bao and her team of researchers at Stanford have spent nearly two decades trying to develop skin-like integrated circuits that can be stretched, folded, bent and twisted — working all the while — and then snap back without fail, every time. Such circuits presage a day of wearable and implantable products, but one hurdle has always stood in the way.

Namely, “How does one produce a completely new technology in quantities great enough to make commercialization possible?” Bao said. Bao and team think they have a solution. In a new study, the group describes how they have printed stretchable-yet-durable integrated circuits on rubbery, skin-like materials, using the same equipment designed to make solid silicon chips — an accomplishment that could ease the transition to commercialization by switching foundries that today make rigid circuits to producing stretchable ones.

Stanford researchers show how to print dense transistor arrays on skin-like materials to create stretchable circuits that flex with the body to perform applications yet to be imagined.

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The oil industry, pharmaceutical companies and bioreactor manufacturers all face one common enemy: bubbles. Bubbles can form during the manufacturing or transport of various liquids, and their formation and rupture can cause significant issues in product quality.

Inspired by these issues and the puzzling physics behind , an international scientific collaboration was born. Stanford University chemical engineer Gerald Fuller along with his Ph.D. students Aadithya Kannan and Vinny Chandran Suja, as well as visiting Ph.D. student Daniele Tammaro from the University of Naples, teamed up to study how different kinds of bubbles pop.

The researchers were particularly interested in bubbles with proteins embedded on their surfaces, which is a common occurrence in the pharmaceutical industry and in bioreactors used for cell culture. In an unanticipated result, the researchers discovered that the protein bubbles they were studying opened up like flowers when popped with a needle. Their findings are detailed in a study published in the journal of the Proceedings of the National Academy of Sciences on July 19.

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A team led by a researcher from the University of Sydney has developed a low-cost, sustainable, and readily available technology that can dim the screens of electronic devices, anti-reflection automobile mirrors, and smart architectural windows at a fraction of the cost of current technology.

It would replace one of the world’s scarcest—yet highly ubiquitous in use—modern materials: indium. A rare chemical element, that it is widely used in devices such as smartphones and computers, windscreen glass and self-dimming windows.

Although small amounts are used to manufacture smart screens, indium is expensive as it is hard to source; it naturally occurs only in small deposits. Industrial indium is often made as a byproduct of zinc mining, which means a shortage could occur if demand for optoelectronic devices—such as LCDs and touch panels—ramps up.

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CHINA’S NEW THORIUM-BASED NUCLEAR REACTOR is well situated for being adopted for Space applications.

China is slowly but steadily positioning itself to leap ahead of the US Space program. It is doing this without pomp and fanfare, and without the idea of a “space race,” simply based upon what it requires for its future.

1) Recent noteworthy progress on molten salt thorium reactors could be a key component of future Chinese space-worthiness. Originally designed by the USA’s Oak Ridge National Laboratory in the 1960’s, they were planned to be used for nuclear powered strategic bomber planes, before the nuclear submarine concept became adopted as more feasible. They were chosen because they can be miniaturized to the size of an aircraft. By the same token, they could conceivably be used in advanced atmospheric or space propulsion.

2) Recently, China announced successful tests on a new type of aircraft that takes in air from the surrounding atmosphere, ionizes it with electricity, and expels it as exhaust. The only thing needed would be a strong enough on-board electrical supply to supply the huge amount of power required. Only a nuclear power plant could supply that power unless it were to be beamed from ground stations. Such a plane would require no fuel for its entire lifetime. It could also function in any atmosphere, not only Earth’s atmosphere, since it is not based on burning fuel chemically, which requires oxygen. Versions of such air-plasma-breathing thrust could be used as part of the boosting phase of a rocket launch system.

3) A few days ago, China tested part of its fully reusable space plane, which is a vastly superior system to SpaceX’s “Starship” rocket. While Starship uses old-fashioned ballistic rocket technology, the Chinese spaceplane, according to reports that have come out, involves something similar to the Sanger space plane design. An early version of the Space Shuttle design also had this configuration. Instead of the Space Shuttle’s dangerous solid rocket boosters on the side, and its external fuel tank, which is dumped once the fuel is used up, such systems have a second “booster aircraft” which glides to a runway after boosting the upper stage orbiter into its atmospheric launch position. So, there are two vehicles which land on a runway, with only the orbiter going into space. In addition to this, the Chinese are adding “combined cycle” technologies, where more than one type of propulsion is being used on the aircraft. So, perhaps turbojets, and scramjets, and rocket engines will be used as one example of such a configuration.

The new molten salt reactors, part of a program developed under the leadership of former Chinese President Zemin’s son, and with collaboration from the US’s Oakridge National Laboratory, is now close to implementation stage. Such reactors could be integrated into a space plane, allowing “single-stage-to-orbit” concepts to become within reach. Such systems would not need a booster phase, but would use a combination of air-plasma-breathing and rocket engines to get to orbit with only a single vehicle, while landing like the Space Shuttle did or perhaps landing with powered flight instead of gliding without fuel as did the Shuttle.

All of this makes China’s plan for “nuclear-powered space shuttles” in the 2040’s very possible. If fusion power is obtained before then, this will all proceed even faster, and all the technical and engineering skills will be immediately brought to bear.

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