Lifeboat Foundation

PCG-1α therapy shows promise in treating age-related decline.

It is always a good idea to look closely at the biochemistry involved in any potential Alzheimer’s disease therapy that shows promise in mouse models. There is perhaps more uncertainty for Alzheimer’s than most other age-related conditions when it comes to the degree to which the models are a useful representation of the disease state in humans — which might go some way towards explaining the promising failures that litter the field. In the research here, the authors are aiming to suppress a step in the generation of amyloid-β, one of the proteins that aggregates in growing amounts and is associated with brain cell death in Alzheimer’s disease. They achieve this goal using gene therapy to increase the level of PGC-1α, which in turn reduces the level of an enzyme involved in the production of amyloid-β. Interestingly, increased levels of PGC-1α have in the past been shown to produce modest life extension in mice, along with some of the beneficial effects to health associated with calorie restriction.

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Now, from the wild side.

Quantum Theory Proves Consciousness Moves To Another Universe After Death. There is an interesting new theory emerging from a scientist long familiar with physics, quantum mechanics and astrophysics. Biocentrism teaches that life and consciousness are fundamental to the universe. It is consciousness that creates the material universe, not the other way around. At least, the new thinking that has given birth to the new theory of biocentrism, which the professor, Dr. Robert Lanza, freely espouses. Lana has been voted the 3rd most important scientist alive by the NY Times. Lanza is an expert in regenerative medicine and scientific director of Advanced Cell Technology Company. Before he has been known for his extensive research which dealt with stem cells, he was also famous for several successful experiments on cloning endangered animal species. Biocentrism—is a concept proposed in 2007 by American doctor of medicine Robert Lanza, a scientist in the fields of regenerative medicine and biology, which sees biology as the central driving science in the universe, and an understanding of the other sciences as reliant on a deeper understanding of biology. Biocentrism states that life and biology are central to being, reality, and the cosmos—consciousness creates the universe rather than the other way around. It asserts that current theories of the physical world do not work, and can never be made to work, until they fully account for life and consciousness. While physics is considered fundamental to the study of the universe, and chemistry fundamental to the study of life, biocentrism claims that scientists will need to place biology before the other sciences to produce a theory of everything.

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In Brief.

• Jean-Pierre Sauvage, Sir Fraser Stoddart and Bernard Feringa will share the prize for their design and synthesis of the ‘world’s smallest machines.’
• The state of molecular machines today is at the same level as that of the electric motor in the 1830’

A trio of European scientists brought home the 2016 Nobel Prize in Chemistry. Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa were awarded 8 million Swedish krona for their work on molecular machines.

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Three pioneers in the development of nanomachines, made of moving molecules, were awarded the Nobel Prize in Chemistry on Wednesday.

Bernard Feringa was the first person to develop a molecular motor; in 1999 he got a molecular rotor blade to spin continually in the same direction. Using molecular motors, he has rotated a glass cylinder that is 10,000 times bigger than the motor and also designed a nanocar.

A tiny lift, artificial muscles and miniscule motors. The Nobel Prize in Chemistry 2016 is awarded to Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa for their design and production of molecular machines. They have developed molecules with controllable movements, which can perform a task when energy is added.

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The Nobel Prize in chemistry was awarded on Wednesday to scientists based in the US, France, and the Netherlands for breakthroughs in designing molecular machines that can carry out tasks— and even mimic a four-wheel-drive car — when given a jolt of energy.

Winners J. Fraser Stoddart, Jean-Pierre Sauvage, and Bernard L. Feringa discovered how to build tiny motors — 1,000 times thinner than a strand of hair.

The machinery includes rings on axles, spinning blades, and even unimaginably small creations consisting of only a few molecules that can lift themselves off a surface like tiny robots rising on tip-toe. Those molecular robots can pluck, grasp, and connect individual amino acids. The machines can also be used as a novel mechanism of drug delivery.

What are the potential uses for molecular machines, which have won the 2016 Nobel Prize in Chemistry.

I never get tired in circuitry thread and any new findings.

Tufts University engineers say that revolutionary health diagnostics may be hanging on a thread—one of many threads they have created that integrate nano-scale sensors, electronics and microfluidics into threads ranging from simple cotton to sophisticated synthetics. “We think thread-based devices could potentially be used as smart sutures for surgical implants, smart bandages to monitor wound healing, or integrated with textile or fabric as personalized health monitors and point-of-care diagnostics,” says Sameer Sonkusale, Ph.D., director of the interdisciplinary Nano Lab in the Department of Electrical and Computer Engineering at Tufts School of Engineering, Medford/Somerville, Mass.

Researchers dipped a variety of conductive threads in physical and chemical sensing compounds and connected them to wireless electronic circuitry. The threads, sutured into tissues of rats, collected data on tissue health (pressure, stress, strain and temperature), pH and glucose levels. The data helps determine how wounds are healing, whether infection is emerging or whether the body’s chemistry is out of balance. Thread’s natural wicking properties draw fluids to the sensing compounds. Resulting data is transmitted wirelessly to a cell phone and computer.

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Multiferroics – materials that exhibit both magnetic and electric order – are of interest for next-generation computing but difficult to create because the conditions conducive to each of those states are usually mutually exclusive. And in most multiferroics found to date, their respective properties emerge only at extremely low temperatures.

Two years ago, researchers in the labs of Darrell Schlom, the Herbert Fisk Johnson Professor of Industrial Chemistry in the Department of Materials Science and Engineering, and Dan Ralph, the F.R. Newman Professor in the College of Arts and Sciences, in collaboration with professor Ramamoorthy Ramesh at UC Berkeley, published a paper announcing a breakthrough in multiferroics involving the only known material in which magnetism can be controlled by applying an electric field at room temperature: the multiferroic bismuth ferrite.

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