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Category: chemistry – Page 265

A hair-like protein hidden inside bacteria serves as a sort of on-off switch for nature’s “electric grid,” a global web of bacteria-generated nanowires that permeates all oxygen-less soil and deep ocean beds, Yale researchers report in the journal Nature. “The ground beneath our feet, the entire globe, is electrically wired,” said Nikhil Malvankar, assistant professor of molecular biophysics and biochemistry at the Microbial Sciences Institute at Yale’s West Campus and senior author of the paper. “These previously hidden bacterial hairs are the molecular switch controlling the release of nanowires that make up nature’s electrical grid.”

Almost all living things breathe oxygen to get rid of excess electrons when converting nutrients into energy. Without access to oxygen, however, living deep under oceans or buried underground over billions of years have developed a way to respire by “breathing minerals,” like snorkeling, through tiny protein filaments called .

Just how these soil bacteria use nanowires to exhale electricity, however, has remained a mystery. Since 2,005 scientists had thought that the nanowires are made up of a protein called “pili” (“hair” in Latin) that many bacteria show on their surface. However, in research published 2019 and 2020, a team led by Malvankar showed that nanowires are made of entirely different proteins. “This was a surprise to everyone in the field, calling into question thousands of publications about pili,” Malvankar said.

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Mitochondrial DNA diseases are common neurological conditions caused by mutations in the mitochondrial genome or nuclear genes responsible for its maintenance. Current treatments for these disorders are focused on the management of the symptoms, rather than the correction of biochemical defects caused by the mutation. Now, scientists at Kyoto University’s Institute for Integrated Cell-Material Science (iCeMS) in Japan report a new approach where mutant DNA sequences inside cellular mitochondria can be eliminated using a bespoke chemical compound. The approach may lead to better treatments for mitochondrial diseases.

Their findings are published in the journal Cell Chemical Biology in a paper titled, “Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation.”

“Mutations in mitochondrial DNA (mtDNA) cause mitochondrial diseases, characterized by abnormal mitochondrial function,” the researchers wrote. “Although eliminating mutated mtDNA has potential to cure mitochondrial diseases, no chemical-based drugs in clinical trials are capable of selective modulation of mtDNA mutations. Here, we construct a class of compounds encompassing pyrrole-imidazole polyamides (PIPs), mitochondria-penetrating peptide, and chlorambucil, an adenine-specific DNA-alkylating reagent.”

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Researchers at North Carolina State University have created a soft and stretchable device that converts movement into electricity and can work in wet environments.

“Mechanical energy—such as the kinetic energy of wind, waves, and vibrations from motors—is abundant,” says Michael Dickey, corresponding author of a paper on the work and Camille & Henry Dreyfus Professor of Chemical and Biomolecular Engineering at NC State. “We have created a that can turn this type of mechanical motion into . And one of its remarkable attributes is that it works perfectly well underwater.”

The heart of the energy harvester is a liquid metal alloy of gallium and indium. The alloy is encased in a hydrogel—a soft, elastic polymer swollen with water.

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Genes can respond to coded information in signals—or filter them out entirely.

New research from North Carolina State University demonstrates that genes are capable of identifying and responding to coded information in light signals, as well as filtering out some signals entirely. The study shows how a single mechanism can trigger different behaviors from the same gene—and has applications in the biotechnology sector.

“The fundamental idea here is that you can encode information in the dynamics of a signal that a gene is receiving,” says Albert Keung, corresponding author of a paper on the work and an assistant professor of chemical and biomolecular engineering at NC State. “So, rather than a signal simply being present or absent, the way in which the signal is being presented matters.”

For this study, researchers modified a yeast cell so that it has a gene that produces fluorescent proteins when the cell is exposed to blue .

Continue reading “Genes can respond to coded information in signals —or filter them out entirely” | >

Science from industry, federal agencies and independent researchers now links 6:2 FTOH to kidney disease, cancer, neurological damage, developmental problems, mottled teeth and autoimmune disorders, while researchers also found higher mortality rates among young animals and human mothers exposed to the chemicals.

Experts previously considered food and water to be the two main routes by which humans are exposed to PFAS, but the study’s authors note that many humans spend about 90% of their time indoors, and the findings suggest that breathing in the chemicals probably represents a third significant exposure route.

“It’s an underestimated and potentially important source of exposure to PFAS,” said Tom Bruton, a co-author and senior scientist at Green Science.

PFAS, or per-and polyfluoroalkyl substances, are a class of about 9,000 compounds used to make products water-, stain-or heat-resistant. Because they are so effective, the chemicals are used across dozens of industries and are in thousands of everyday consumer products such as stain guards, carpeting and shoes. Textile manufacturers use them to produce waterproof clothing, and they are used in floor waxes, nonstick cookware, food packaging, cosmetics, firefighting foam and much more.

Continue reading “Toxic ‘forever chemicals’ contaminate indoor air at worrying levels, study finds” | >

Would you wear clothing made of muscle fibers? Use them to tie your shoes or even wear them as a belt? It may sound a bit odd, but if those fibers could endure more energy before breaking than cotton, silk, nylon, or even Kevlar, then why not?

Don’t worry, this muscle could be produced without harming a single animal.

Researchers at the McKelvey School of Engineering at Washington University in St. Louis have developed a synthetic chemistry approach to polymerize proteins inside of engineered microbes. This enabled the microbes to produce the high molecular weight muscle protein, titin, which was then spun into fibers.

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There’s no need to don uncomfortable smartwatches or chest straps to monitor your heart if your comfy shirt can do a better job.

That’s the idea behind “” developed by a Rice University lab, which employed its conductive nanotube thread to weave functionality into regular apparel.

The Brown School of Engineering lab of chemical and biomolecular engineer Matteo Pasquali reported in the American Chemical Society journal Nano Letters that it sewed nanotube fibers into athletic wear to monitor the heart rate and take a continual electrocardiogram (EKG) of the wearer.

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Technion scientists have created a wearable motion sensor capable of identifying movements such as bending and twisting. This smart ‘e-skin’ was produced using a highly stretchable electronic material, which essentially forms an electronic skin capable of recognizing the range of movement human joints normally make, with up to half a degree precision.

This breakthrough is the result of collaborative work between researchers from different fields in the Laboratory for Nanomaterial-Based Devices, headed by Professor Hossam Haick from the Technion Wolfson Faculty of Chemical Engineering. It was recently published in Advanced Materials and was featured on the journal’s cover.

This wearable motion sensor, which senses bending and twisting, can be applied in healthcare and manufacturing.

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Stanford University scientists experimenting with a decades-old, single-use battery architecture have developed of a new version that is not only rechargeable, but offers around six times the capacity of today’s lithium-ion solutions. The breakthrough hinges on the stabilization of volatile chlorine reactions within the device, and could one day provide the basis for high-performance batteries that power smartphones for a week at a time.

The new battery is described as an alkali metal-chlorine battery, and is based on chemistry that first emerged in the 1970s called lithium-thionyl chloride. These batteries are highly regarded for their high energy density, but rely on highly reactive chlorine that makes them unsuitable for anything other than a single use.

In a regular rechargeable battery, the electrons travel from one side to the other during discharging and then are reverted back to their original form as the battery is recharged. In this case, however, the sodium chloride or lithium chloride is converted to chlorine, which is too reactive to be converted back to chloride with any great efficiency.

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