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The mysterious ways cancer spreads through the body, a process known as metastasis, is what can make it such a difficult enemy to keep at bay. Researchers at Princeton University working in this area have been tugging at a particular thread for more than 15 years, focusing on a single gene central to the ability of most major cancers to metastasize. They’ve now discovered what they describe as a “silver bullet” in the form of a compound that can disable this gene in mice and human tissue, with clinical trials possibly not too far away.

Metastatic cancer is a key focus for researchers and with good reason, as it is actually the primary cause of death from the disease. While surgery or chemotherapy might be effective at eliminating an initial tumor, cells that have broken away can discreetly make their way around the body and give rise to new tumors, months or even years later.

“Metastatic breast cancer causes more than 40,000 deaths every year in the US, and the patients do not respond well to standard treatments, such as chemotherapies, targeted therapies and immunotherapies,” says Minhong Shen, member of the Princeton team behind the new discovery. “Our work identified a series of chemical compounds that could significantly enhance the chemotherapy and immunotherapy response rates in metastatic breast cancer mouse models. These compounds have great therapeutic potential.”

Circa 2019


Cellular enhancement in banana leaves

Banana Leaf Technology started in 2010 when Tenith Adithyaa, then 11 years old, saw farmers in Southern India dump heaps of banana leaves as trash due to the lack of a preservation technology. The spark ignited when the question came to the mind, ‘can these leaves be enhanced biologically?’ By trial and error, he succeeded in preserving the leaves for about a year without using any chemicals. For four years, he perfected his technology of cellular enhancement. He received his first international award for this technology in 2014, at the global invention fair in Texas.

The extra juice comes from a secret ingredient…corn starch.


Could a simple materials change make electric car batteries able to four times more energy? Scientists in South Korea think so. In a new paper in the American Chemical Society’s Nano Letters, a research team details using silicon and repurposed corn starch to make better anodes for lithium ion batteries.

This team is based primarily in the Korea Institute of Science and Technology (KIST), where they’ve experimented with microemulsifying silicon, carbon, and corn starch into a new microstructured composite material for use as a battery anode. This is done by mixing silicon nanoparticles and corn starch with propylene gas and heating it all to combine.

Using biowaste corn starch is already pretty popular, with products like biodegradeable “corn plastic” cutlery, packaging, and the infamous nontoxic packing peanut. The same qualities that make corn starch attractive in these applications apply to the silicon anode project. Existing lithium-ion batteries use carbon anodes, and scientists know silicon would work better in many ways but have struggled to stabilize the silicon enough for this use to be practical. “To enhance the stability of silicon, Dr. Jung and his team focused on using materials that are common in our everyday lives, such as water, oil, and starch,” KIST wrote in a statement about the paper.

A team of researchers from Harvard University and Brigham and Women’s Hospital, Harvard Medical School, has developed a type of living ink that can be used to print living materials. In their paper published in the journal Nature Communications, the group describes how they made their ink and possible uses for it.

For several years, microbial engineers have been working to develop a means to create living materials for use in a wide variety of applications such as medical devices. But getting such materials to conform to desired 3D structures has proven to be a daunting task. In this new effort, the researchers have taken a new approach to tackling the problem—engineering Escherichia coli to produce a product that can be used as the basis for an ink for use in a 3D printer.

The work began by bioengineering the bacteria to produce living nanofibers. The researchers then bundled the fibers and added other ingredients to produce a type of living ink that could be used in a conventional 3D printer. Once they found the concept viable, the team bioengineered other microbes to produce other types of living fibers or materials and added them to the ink. They then used the ink to print 3D objects that had living components. One was a material that secreted azurin—an anticancer drug—when stimulated by certain chemicals. Another was a material that sequestered Bisphenol A (a toxin that has found its way into the environment) without assistance from other chemicals or devices.

Solid-solution organic crystals have been brought into the quest for superior photon upconversion materials, which transform presently wasted long-wavelength light into more useful shorter wavelength light. Scientists from Tokyo Institute of Technology have revisited a materials approach previously deemed lackluster—using a molecule originally developed for organic LEDs—and have achieved outstanding performance and efficiency. Their findings pave the way for many novel photonic technologies, such as better solar cells and photocatalysts for hydrogen and hydrocarbon productions.

Light is a powerful source of energy that can, if leveraged correctly, be used to drive stubborn chemical reactions, generate electricity, and run optoelectronic devices. However, in most applications, not all the wavelengths of can be used. This is because the energy that each photon carries is inversely proportional to its wavelength, and chemical and are triggered by light only when the energy provided by individual photons exceeds a certain threshold.

This means that devices like solar cells cannot benefit from all the color contained in sunlight, as it comprises a mixture of photons with both high and low energies. Scientists worldwide are actively exploring materials to realize upconversion (PUC), by which photons with lower energies (longer wavelengths) are captured and re-emitted as photons with higher energies (shorter wavelengths). One promising way to realize this is through triplet-triplet annihilation (TTA). This process requires the combination of a sensitizer material and an annihilator material. The sensitizer absorbs low energy photons (long-wavelength light) and transfers its excited energy to the annihilator, which emits higher photons (light of shorter wavelength) as a result of TTA.

Solid-state nuclear magnetic resonance (NMR) spectroscopy—a technique that measures the frequencies emitted by the nuclei of some atoms exposed to radio waves in a strong magnetic field—can be used to determine chemical and 3D structures as well as the dynamics of molecules and materials.

A necessary initial step in the analysis is the so-called chemical shift assignment. This involves assigning each peak in the NMR spectrum to a given atom in the molecule or material under investigation. This can be a particularly complicated task. Assigning chemical shifts experimentally can be challenging and generally requires time-consuming multi-dimensional correlation experiments. Assignment by comparison to statistical analysis of experimental chemical shift databases would be an alternative solution, but there is no such for molecular solids.

A team of researchers including EPFL professors Lyndon Emsley, head of the Laboratory of Magnetic Resonance, Michele Ceriotti, head of the Laboratory of Computational Science and Modeling and Ph.D. student Manuel Cordova decided to tackle this problem by developing a method of assigning NMR spectra of organic crystals probabilistically, directly from their 2D chemical structures.

“We are proud to be able to showcase the world’s first fully electric and self-propelled container ship,” said Svein Holsether, CEO of Norwegian chemical company Yara International. “It will cut 1,000 tonnes of CO2 and replace 40,000 trips by diesel-powered trucks a year.”

Yara has collaborated since 2017 with maritime technology company Kongsberg to develop the ship, which sailed from Horten to Oslo, a distance of approximately 35 nautical miles (65 km). Powered by 7 MWh batteries, it uses an automatic identification system (AIS), cameras (including infrared), a lidar, and radar system. It will begin commercial operations in 2022, transporting mineral fertiliser between ports in southern Norway at up to 15 knots (28 km/h).

“Norway is a big ocean and maritime nation, and other nations look to Norway for green solutions at sea. Yara Birkeland is the result of the strong knowledge and experience we have in the Norwegian maritime cluster and industry,” said Geir Håøy, CEO of the Kongsberg Group. “The project demonstrates how we have developed a world-leading innovation that contributes to the green transition and provides great export opportunities for Norwegian technology and industry.”

It is the hardest known glass with the highest thermal conductivity among all glass materials.

Carnegie’s Yingwei Fei and Lin Wang were part of an international research team that synthesized a new ultrahard form of carbon glass with a wealth of potential practical applications for devices and electronics. It is the hardest known glass with the highest thermal conductivity among all glass materials. Their findings are published in Nature.

Function follows form when it comes to understanding the properties of a material. How its atoms are chemically bonded to each other, and their resulting structural arrangement, determines a material’s physical qualities—both those that are observable by the naked eye and those that are only revealed by scientific probing.

Ammolite is an opal-like organic gemstone found primarily along the eastern slopes of the Rocky Mountains of North America. It is made of the fossilized shells of ammonites, which in turn are composed primarily of aragonite, the same mineral contained in nacre, with a microstructure inherited from the shell. It is one of few biogenic gemstones; others include amber and pearl.

The chemical composition of ammolite is variable, and aside from aragonite may include calcite, silica, pyrite, or other minerals. The shell itself may contain a number of trace elements, including: aluminium; barium; chromium; copper; iron; magnesium; manganese; strontium; titanium; and vanadium. Its crystallography is orthorhombic. Its hardness is 4.5–5.5, and its specific gravity is 2.60–2.85.

An iridescent opal-like play of color is shown in fine specimens, mostly in shades of green and red; all the spectral colors are possible, however. The iridescence is due to the microstructure of the aragonite: unlike most other gems, whose colors come from light absorption, the iridescent color of ammolite comes from interference with the light that rebounds from stacked layers of thin platelets that make up the aragonite.

It could replace cartilage in knees and even help create soft robots 🤯


Is it a bird? Is it a plane? No, it’s ‘super jelly’ — a bizarre new material that can survive being run over by a car even though it’s composed of 80 per cent water.

The ‘glass-like hydrogel’ may look and feel like a squishy jelly, but when compressed it acts like shatterproof glass, its University of Cambridge developers said.

It is formed using a network of polymers held together by a series of reversible chemical interactions that can be tailored to control the gel’s mechanical properties.