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NSD2 is the fourth protective factor of cellular senescence that our team has identified,” said Professor Mitsuyoshi Nakao. “With the discovery that NSD2 protects against cellular senescence, this study clarifies a basic mechanism of aging.

Researchers from Kumamoto University in Japan have used comprehensive genetic analysis to find that the enzyme NSD2, which is known to regulate the actions of many genes, also works to block cell aging. Their experiments revealed 1) inhibition of NSD2 function in normal cells leads to rapid senescence and 2) that there is a marked decrease in the amount of NSD2 in senescent cells. The researchers believe their findings will help clarify the mechanisms of aging, the development of control methods for maintaining NSD2 functionality, and age-related pathophysiology.

As the cells of the body continue to divide (cell reproduction), their function eventually declines and they stop growing. This cellular senescence is an important factor in health and longevity. Cell aging can also be stimulated when genomic DNA is damaged by physical stress, such as radiation or ultraviolet rays, or by chemical stress that occurs with certain drugs. However, the detailed mechanisms of aging are still unknown. Cell aging can be beneficial when a cell becomes cancerous; it prevents malignant changes by causing cellular senescence. On the other hand, it makes many diseases more likely with age. It is therefore important that cell aging is properly controlled.

Continue reading “NSD2 shapes the program of cell senescence [image] Science News” »

Free radicals—atoms and molecules with unpaired electrons—can wreak havoc on the body. They are like jilted paramours, destined to wander about in search of another electron, leaving broken cells, proteins and DNA in their wakes.

Hydroxyl radicals are the most chemically aggressive of the free radicals, surviving for only trillionths of a second. They form when water, the most abundant molecule in cells, is hit with radiation, causing it to lose an electron. In previous research, a team led by Linda Young, a scientist at the Department of Energy’s Argonne National Laboratory, observed the ultrafast birth of these free radicals, a process with great significance in fields such as sunlight-induced biological damage, environmental remediation, nuclear engineering, and space travel.

Now her team, including researchers from DOE’s SLAC National Accelerator Laboratory, has teased out a unique chemical fingerprint of the hydroxyl, which will help scientists track chemical reactions it instigates in complex biological environments. They published their results in Physical Review Letters in June.

Developed in the 1970s, rare-earth magnets are the strongest type of permanent magnets made today. The more common type are neodymium alloys made with iron and boron, while the other group is samarium-cobalt magnets. The occurrence and production of these chemical elements raise both political and environmental concerns, so to find a more sustainable solution, the UK’s Office of Low Emission Vehicles is funding a nine-partner study called OCTOPUS (Optimised Components, Test and simulatiOn, toolkits for Powertrains which integrate Ultra high-speed motor Solutions). With Bentley joining for the next three years, the program will aim for real-world applications by 2026. Coincidentally, Bentley’s first full EV is also due that year.

As the world’s most popular shoe, flip-flops account for a troubling percentage of plastic waste that ends up in landfills, on seashores and in our oceans. Scientists at the University of California San Diego have spent years working to resolve this problem, and now they have taken a step farther toward accomplishing this mission.

Sticking with their chemistry, the team of researchers formulated polyurethane foams, made from algae oil, to meet commercial specifications for midsole shoes and the foot-bed of flip-flops. The results of their study are published in Bioresource Technology Reports and describe the team’s successful development of these sustainable, consumer-ready and biodegradable materials.

The research was a collaboration between UC San Diego and startup company Algenesis Materials—a materials science and technology company. The project was co-led by graduate student Natasha Gunawan from the labs of professors Michael Burkart (Division of Physical Sciences) and Stephen Mayfield (Division of Biological Sciences), and by Marissa Tessman from Algenesis. It is the latest in a series of recent research publications that collectively, according to Burkart, offer a complete solution to the plastics problem—at least for polyurethanes.

In COVID-19, the sense of smell can diminish, vanish, or oddly skew, for weeks or months. The loss usually starts suddenly and is more than the temporarily dulled chemical senses of a stuffy nose from the common cold. As researchers followed up mounting reports of loss of olfaction, a surprising source of perhaps the longest-lasting cases emerged: stem cells in the olfactory epithelium.

A Common Symptom

Facebook groups may be ahead of the medical literature in providing vivid descriptions of the loss of olfaction as people swap advice and compare how long they’ve been unable to smell. The experiences can be bizarre, but at the same time, shared.

Imagine tiny crystals that “blink” like fireflies and can convert carbon dioxide, a key cause of climate change, into fuels.

A Rutgers-led team has created ultra-small titanium dioxide crystals that exhibit unusual “blinking” behavior and may help to produce methane and other fuels, according to a study in the journal Angewandte Chemie. The crystals, also known as nanoparticles, stay charged for a long time and could benefit efforts to develop quantum computers.

“Our findings are quite important and intriguing in a number of ways, and more research is needed to understand how these exotic crystals work and to fulfill their potential,” said senior author Tewodros (Teddy) Asefa, a professor in the Department of Chemistry and Chemical Biology in the School of Arts and Sciences at Rutgers University-New Brunswick. He’s also a professor in the Department of Chemical and Biochemical Engineering in the School of Engineering.

face_with_colon_three yay closer to foglet bodies: 3.

Is the T-1000 no longer science fiction?

It is a human dream to realize a robot with automatic mechanical functions similar to the robots presented in several science-fiction movies and series such as “Ex Machina”, “Black Mirror”, “The Terminator”, etc.

Continue reading “Liquid-Metal-Driven Micromachines for the Next Cutting-edge Technology” »

Scientists are ramping up their efforts in the search for signs of alien life.

Experts at the SETI Institute, an organization dedicated to tracking extraterrestrial intelligence, are developing state-of-the-art techniques to detect signatures from space that indicate the possibility of extraterrestrial existence.

These so-called “technosignatures” can range from the chemical composition of a planet’s atmosphere, to laser emissions, to structures orbiting other stars, among others, they said.

Circa 2011

Gravity is no obstacle for this climbing robot. It scales vertical walls—even those made of smooth materials like glass. Jeff Krahn, an engineer from Simon Fraser University in British Columbia, created this gecko-inspired tank of a robot, which he detailed in a paper in the journal Smart Materials and Structures this week.

Continue reading “A Gecko-Inspired, Wall-Climbing Tank Bot” »