Molnupiravir, a wide-spectrum antiviral that is currently in phase 2/3 clinical trials for the treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as ‘lethal mutagenesis’. Two recently published studies reveal the biochemical and structural bases of how molnupiravir disrupts the fidelity of SARS-CoV-2 genome replication and prevents viral propagation by fostering error accumulation in a process referred to as ‘error catastrophe’.
Analysis of unique fingerprints in light emitted from material surrounding young stars has revealed “significant reservoirs” of large organic molecules necessary to form the basis of life, say researchers.
Dr. John Ilee, Research Fellow at the University of Leeds who led the study, says the findings suggest that the basic chemical conditions that resulted in life on Earth could exist more widely across the Galaxy.
The large organic molecules were identified in protoplanetary disks circling newly formed stars. A similar disk would have once surrounded the young Sun, forming the planets that now make up our Solar System. The presence of the molecules is significant because they are “stepping-stones” between simpler carbon-based molecules such as carbon monoxide, found in abundance in space, and more complex molecules that are required to create and sustain life.
September 15 2021 — Breathe in, breathe out. That’s how easy it is for SARS-CoV-2, the virus that causes COVID-19, to enter your nose. And though remarkable progress has been made in developing intramuscular vaccines against SARS-CoV-2 such as the readily available Pfizer, Moderna and Johnson & Johnson vaccines, nothing yet – like a nasal vaccine – has been approved to provide mucosal immunity in the nose, the first barrier against the virus before it travels down to the lungs.
But now, we’re one step closer.
Navin Varadarajan, University of Houston M.D. Anderson Professor of Chemical and Biomolecular Engineering, and his colleagues, are reporting in iScience the development of an intranasal subunit vaccine that provides durable local immunity against inhaled pathogens.
In humans, as well as all vertebrate animals, turning a fertilized egg into an embryo with a little beating heart requires that stem cells differentiate, specialize, and generate specific tissues, such as bones, blood vessels and a nervous system. This process is kickstarted and regulated by retinal. Animals can’t produce their own retinal, though, they must ingest it from plants, or from animals that eat plants.
Plant roots and animal embryos rely on the same chemical for successful development.
What do frog eggs have in common with anti-aging creams? Their success depends on a group of chemical compounds called retinoids, which are capable of generating and re-generating tissues.
A new study in plants shows that retinoids’ tissue-generating capacities are also responsible for the appropriate development of roots.
Scientists have found a new chemical process to turn a stinky, toxic gas into a clean-burning fuel.
The process, detailed recently in the American Chemical Society journal ACS Sustainable Chemical Engineering, turns hydrogen sulfide —more commonly called “sewer gas”—into hydrogen fuel. Hydrogen sulfide is emitted from manure piles and sewer pipes and is a key byproduct of industrial activities including refining oil and gas, producing paper and mining.
The process detailed in this study uses relatively little energy and a relatively cheap material—the chemical iron sulfide with a trace amount of molybdenum as an additive.
Summary: A new study on aging reveals a surprising discovery about the connection between protein shape and mitochondrial health.
Source: Buck Institute.
Every cell in the body goes through thousands of chemical reactions each day, and each reaction involves tiny protein molecules folded into precise shapes to perform their functions. Misfolded proteins underlie some of the most common and devastating diseases of aging, like Alzheimer’s and Parkinson’s. A major focus of aging research is discovering ways to maintain protein shape and prevent misfolded proteins from wreaking havoc on cellular function.
Circa 2012
Quantum ground-state problems are computationally hard problems for general many-body Hamiltonians; there is no classical or quantum algorithm known to be able to solve them efficiently. Nevertheless, if a trial wavefunction approximating the ground state is available, as often happens for many problems in physics and chemistry, a quantum computer could employ this trial wavefunction to project the ground state by means of the phase estimation algorithm (PEA). We performed an experimental realization of this idea by implementing a variational-wavefunction approach to solve the ground-state problem of the Heisenberg spin model with an NMR quantum simulator. Our iterative phase estimation procedure yields a high accuracy for the eigenenergies (to the 10–5 decimal digit).