Lifeboat Foundation

Relief could be on the way for people with painful hand osteoarthritis after a Monash University and Alfred Health-led study found an affordable existing drug can help. Until now there has been no effective treatment.

Published in The Lancet, the paper investigated methotrexate, a low-cost, effective treatment for inflammatory joint conditions such as rheumatoid arthritis and psoriatic arthritis. It has been widely used in Australia and globally since the early 1980s.

Researchers found that methotrexate reduced symptoms in those with hand osteoarthritis (OA). A 20mg weekly oral dose over six months had a moderate effect in reducing pain and stiffness in patients with symptomatic hand OA.

🥼 Researchers from the Netherlands Institute for Neuroscience and the VIB-KU Leuven Center for Brain and Disease Research have shown that microRNA-132 can significantly affect different brain cells, with potential implications for Alzheimer’s disease ✔️

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Research shows that microRNA-132 can significantly affect different brain cells, with potential implications for Alzheimer’s disease. Find out more.

Continue reading “Honey, I Shrunk the Molecules” »

The research paper explores the multifaceted role of the IL-17 family in immune response, covering everything from infection control to pathological conditions like autoimmune diseases and cancer. Future therapies may exploit IL-17’s unique signaling pathways to offer more targeted and cost-effective treatments.

A team of atmospheric scientists, chemists and infectious disease specialists at the Max Planck Institute for Chemistry, working with colleagues from the Max Planck Institute for Dynamical Systems, the University of Denver, Georg August University and St. Petersburg State University, has embarked on an effort to collate publicly available information on droplet properties, such as the way they are distributed by size, their composition, and the ways they are emitted, as a means of helping to develop mitigation strategies for fighting infectious agents.

In their paper published in the journal Reviews of Modern Physics, the group describes their collating process and why they believe it could help fight non-contact infectious diseases.

In the early days of the pandemic, as people around the world locked themselves inside their residences, scientists, including those not in the medical field, looked for ways to help. One such pair of researchers, Christopher Pöhlker, an atmospheric scientist, and his wife, Mira, a cloud scientist, began to wonder about the nature of droplet size—something related to both their fields of work.

Do you think human beings are the last stage in evolution? If not, what comes next?

I do not think human beings are the last stage in the evolutionary process. Whatever comes next will be neither simply organic nor simply machinic but will be the result of the increasingly symbiotic relationship between human beings and technology.

Bound together as parasite/host, neither people nor technologies can exist apart from the other because they are constitutive prostheses of each other. Such an interrelation is not unique to human beings. As the physiologist J. Scott Turner writes in “The Extended Organism”: “Animal-built structures are properly considered organs of physiology, in principle no different from, and just as much a part of the organism as kidneys, heart, lungs or livers.” This is true for termites, for example, who form a single organism in symbiosis with their nests. The extended body of the organism is created by the extended mind of the colony.

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

An Australian first biobank will be established to improve and discover new treatments for children with genetic muscle diseases.

The National Muscle Disease Bio-databank, co-led by Murdoch Children’s Research Institute, Monash University and The Alfred, will advance research into our understanding of why children develop genetic muscle diseases.

These diseases, spanning dystrophies and myopathies, are characterised by severe muscle weakness, usually from infancy, that can impact swallowing, breathing and lead to eye problems and learning difficulties.

Continue reading “Biobank aims to discover new treatments for children with genetic muscle diseases” »

So many ways. But one crucial use is to help understand the basis of brain diseases. A reference human brain atlas that describes a normal or neurotypical brain could help researchers understand depression or schizophrenia or many other kinds of diseases, Lein says. Take Alzheimer’s as an example. You could apply these same methods to characterize the brains of people with differing levels of severity of Alzheimer’s, and then compare those brain maps with the reference atlas. “And now you can start to ask questions like, ‘Are certain kinds of cells vulnerable in disease, or are certain kinds of cells causal,” Lein says. (He’s part of a team that’s already working on this.) Rather than investigating plaques and tangles, researchers can ask questions about “very specific kinds of neurons that are the real circuit elements that are likely to be perturbed and have functional consequences,” he says.

What’s the next step?

Better resolution. “The next phase is really moving into very comprehensive coverage of the human and non-human primate brain in adults and development.” In fact, that work has already begun with the BRAIN Initiative Cell Atlas Network, a five-year, $500 million project. The aim is to generate a complete reference atlas of cell types in the human brain across the lifespan, and also to map cell interactions that underlie a wide range of brain disorders.

A kilonova is a bright blast of electromagnetic radiation that happens when two neutron stars or a neutron star and a stellar-mass black hole collide and merge.

When these collisions occur, a vast amount of material is ejected from the neutron stars, the ultradense cores of massive stars that have reached the ends of their lives. This matter is rich in neutral particles called neutrons, and in this violent sea of particles around a neutron star merger, the heaviest elements of the periodic table are forged. These include gold and platinum, radioactive materials such as uranium, and the iodine that flows through our blood. In fact, many pieces of jewelry owe their existence to a kilonova-triggering event.