Lifeboat Foundation

Would you share your data for the common good? Biomechanist Jacqueline Alderson shows how sophisticated simulations based on real data can help prevent disease, illness and injury. Jacqueline Alderson is an Associate Professor of Biomechanics at the University of Western Australia and Adjunct Professor of Human Performance, Innovation and Technology at the Auckland University of Technology. She has always been curious about movement — whether it’s helping surgeons make best practice decisions or helping AFL players avoid knee injuries. She now travels the world to share her knowledge in human movement, wearable tech and artificial intelligence and its role in tracking, analysing and intervening in the human condition. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

While many people in wealthier countries have been vaccinated against COVID-19, there is still a need for vaccination in much of the world. A new vaccine developed at MIT and Beth Israel Deaconess Medical Center may aid in those efforts, offering an inexpensive, easy-to-store, and effective alternative to RNA vaccines.

In a new paper, the researchers report that the vaccine, which comprises fragments of the SARS-CoV-2 spike protein arrayed on a virus-like particle, elicited a strong immune response and protected animals against viral challenge.

The vaccine was designed so that it can be produced by yeast, using fermentation facilities that already exist around the world. The Serum Institute of India, the world’s largest manufacturer of vaccines, is now producing large quantities of the vaccine and is running a clinical trial in Africa.

Dry, hot regions are difficult places to grow plants because the soil dries out quickly. As a result, farmers in arid and semi-arid regions irrigate their fields with buried networks of irrigation tubing and cover the ground with plastic sheets. But plastic sheets are expensive and create waste. Now, researchers reporting in ACS Agricultural Science & Technology have developed a simple, biodegradable ground cover—wax-coated sand—which keeps soil wet and increases crop yields.

To irrigate crops, farmers usually get water from nearby waterways or underground aquifers. These supplies can be rapidly depleted when growing plants in arid regions, where the soil is comprised mostly of sand and can’t hold onto water well. One way to improve irrigated water’s efficiency is to make sure it stays in the soil long enough so that plants’ roots can take it up. Previous studies have shown that ground cover barriers, such as plastic sheets and engineered nanomaterials, can slow evaporation and enhance plant growth and crop yields. However, both could leach unwanted compounds into the soil with unknown long-term impacts. Some plants and animals naturally produce waxy substances that trap and pool water from fog or condensation so that they can access these moisture sources. Taking inspiration from nature, Himanshu Mishra and colleagues wanted to see if they could coat sand with wax, creating an environmentally benign ground cover to control soil evaporation.

The researchers chose purified paraffin wax, a biodegradable substance available in large quantities, for their experiments. They dissolved the wax in hexane and poured silica sand into the mixture. As the solvent evaporated, a 20-nm-thick coating of wax was left behind on the grains. When the team applied the wax-coated sand in a thin layer on an open field in Saudi Arabia, it decreased the loss of soil moisture up to 50–80%. Field trials revealed that tomato, barley and wheat plants mulched with the new material produced substantially more fruit and grain than those grown in uncovered soil. In addition, the microbial community around the plants’ roots and in the soil wasn’t negatively impacted by the waxy mulch, which could have acted as a food source for some of the microbes. This simple nature-inspired technology could make water use more efficient in arid regions, the researchers say.

De-extinction grabbed our imagination in the 90s with Jurassic Park. Scientists have since asked: how possible is it?

According to a new study, nearly impossible. But wait—it’s not all bad news. While bringing back a faithful copy of an extinct species may be impossible, we could bring back a hybrid species that’s a genetic mix between an extinct species and its modern descendant.

Published in Current Biology, the study eschews the grandiose mammoth, instead focusing on a tiny test case: the Christmas Island rat. Hefty in size and loudly vocal when invading docked ships and their cargo, the rodents were last seen in the 1900s. With a stroke of luck, the team recovered DNA from two well-preserved museum samples and compared them against a close relative: the Norway brown rat, a popular lab model for genetic studies today.

The last-mile mobile health services provider, DocGo, has announced the delivery of its new all-electric, zero-emissions ambulance that eliminates the pollution of a standard gasoline ambulance.

The all–electric vehicle will be the first of its kind to be registered in the U.S. The new vehicle has been developed in partnership with Leader Emergency Vehicles in South El Monte, CA, and marks the first step towards “Zero Emission,” the company’s latest sustainability mission to have an all-electric fleet by 2032.

DocGo stated that its new vehicle produces 1/10th of the pollutants expelled by a standard gas-powered ambulance. In addition to being less harmful to the planet, the electric ambulance has the potential to lower patient transportation costs due to lower fuel costs and maintenance needs.

(Inside Science) — An enzyme in the bacterium E. coli made more errors copying synthetic DNA when exposed to zero gravity than the same enzyme did in normal gravity, a recent study finds.

The paper raises the possibility that some enzymes work differently in space compared to on Earth. “It gives us an idea that enzymes, like polymerases or others that are involved in maintaining the integrity of our DNA, may be influenced by spaceflight,” said Susan Bailey, a radiation cancer biologist at Colorado State University in Fort Collins who has studied DNA damage caused by space radiation and did not contribute to the new paper.

Aaron Rosenstein, lead author of the paper and a bioengineering graduate student at the University of Toronto, said the finding “warrants further investigation into other enzymes that are involved in crucial pathways that are inherent to life and survival.”

Last summer, at a time when the pandemic had strained many people’s finances, inflation was rising and unemployment was still high, the sight of the richest man in the world joyriding in space hit a nerve. On July 20 Amazon founder Jeff Bezos rode to the edge of space onboard a rocket built by his company Blue Origin. A few weeks earlier ProPublica had revealed that he did not pay any income taxes for two years, and in other years he paid a tax rate of just 0.98 percent. To many watching, it rang hollow when Bezos thanked Amazon’s workers, whose low-paid labor had enriched him enough to start his own rocket company, even though Amazon had quashed workers’ efforts to unionize several months before. The fact that another billionaire, Richard Branson, had also launched himself onboard his own company’s rocket just a week earlier did not help.

COVID changed many people’s willingness to shrug off the excesses of the rich. The pandemic drew an impossible-to-ignore distinction between those who can literally escape our world and the rest of us stuck on the ground confronting the ills of Earth: racism, climate change, global diseases. Even several members of Congress expressed their disapproval of Bezos. “Space travel isn’t a tax-free holiday for the wealthy,” said Representative Earl Blumenauer of Oregon. Bezos and Branson putting the spotlight on themselves as passengers served to downplay the work that hundreds of scientists and engineers at Blue Origin and Virgin Galactic had put into designing, building and testing their spacecraft. It also masked the reality that advances in private spaceflight really could eventually pay off in greater access to space for all and more opportunities for scientific research that could benefit everyone. All their flights did was give the impression that space—historically seen as a brave pursuit for the good of all humankind—has just become another playground for the 0.0000001 percent.

Synopsis: No sentient being in the evolutionary history of life has enjoyed good health as defined by the World Health Organization. The founding constitution of the World Health Organization commits the international community to a daringly ambitious conception of health: “a state of complete physical, mental and social wellbeing”. Health as so conceived is inconsistent with evolution via natural selection. Lifelong good health is inconsistent with a Darwinian genome. Indeed, the vision of the World Health Organization evokes the World Transhumanist Association. Transhumanists aspire to a civilization of superhappiness, superlongevity and superintelligence; but even an architecture of mind based on information-sensitive gradients of bliss cannot yield complete well-being. Post-Darwinian life will be sublime, but “complete” well-being is posthuman – more akin to Buddhist nirvana. So the aim of this talk is twofold. First, I shall explore the therapeutic interventions needed to underwrite the WHO conception of good health for everyone – or rather, a recognisable approximation of lifelong good health. What genes, allelic combinations and metabolic pathways must be targeted to deliver a biohappiness revolution: life based entirely on gradients of well-being? How can we devise a more civilized signalling system for human and nonhuman animal life than gradients of mental and physical pain? Secondly, how can genome reformists shift the Overton window of political discourse in favour of hedonic uplift? How can prospective parents worldwide – and the World Health Organization – be encouraged to embrace genome reform? For only germline engineering can fix the problem of suffering and create a happy biosphere for all sentient beings.

https://www.scifuture.org/the-end-of-suffering-genome-reform…id-pearce/

Immortal jellyfish could actually be the key to immortality and regeneration. This article talks more in depth of its importance in the search of immortality.

Turritopsis nutricula (T. nutricula) is the one of the known reported organisms that can revert its life cycle to the polyp stage even after becoming sexually mature, defining itself as the only immortal organism in the animal kingdom. Therefore, the animal is having prime importance in basic biological, aging, and biomedical researches. However, till date, the genome of this organism has not been sequenced and even there is no molecular phylogenetic study to reveal its close relatives. Here, using phylogenetic analysis based on available 16s rRNA gene and protein sequences of Cytochrome oxidase subunit-I (COI or COX1) of T. nutricula, we have predicted the closest relatives of the organism. While we found Nemopsis bachei could be closest organism based on COX1 gene sequence; T. dohrnii may be designated as the closest taxon to T. nutricula based on rRNA. Moreover, we have figured out four species that showed similar root distance based on COX1 protein sequence.

Keywords: Turritopsis nutricula, immortal jellyfish, trans-differentiation, phylogeny, relativeness.

Continue reading “The conserved mitochondrial gene distribution in relatives of Turritopsis nutricula, an immortal jellyfish” »