Lifeboat Foundation

On 30 January 2020 COVID-19 was declared a Public Health Emergency of International Concern (PHEIC) with an official death toll of 171. By 31 December 2020, this figure stood at 1 813 188. Yet preliminary estimates suggest the total number of global deaths attributable to the COVID-19 pandemic in 2020 is at least 3 million, representing 1.2 million more deaths than officially reported.

With the latest COVID-19 deaths reported to WHO now exceeding 3.3 million, based on the excess mortality estimates produced for 2020, we are likely facing a significant undercount of total deaths directly and indirectly attributed to COVID-19.

Continue reading “The true death toll of COVID-19” »

Leukaemia patients were successfully treated with first-in-human “universal” CRISPR-edited T-cells by specialist researchers.

Even more daring, biology’s “mirror dimension” may be a springboard to engineer synthetic life forms that exist outside of nature, but are literal reflections of ourselves. To rephrase: building a mirror-image version of biology means rewriting the fundamental operating system of life.

Sound a bit too sci-fi? Let me explain. Similar to how our left hand can’t wear a right-hand glove, the building blocks of life—DNA, RNA, and proteins—are etched into specific 3D structures. Flip them around, as if reflected by a mirror, and they can no longer function inside the body. Scientists aren’t yet sure why nature picked just one shape out of two potential mirror images. But they’re ready to test it out.

A new study in Science made strides by reworking parts of the body’s protein-making machine into its mirror image. At the center is a structure called the ribosome, which intakes genetic code and translates it into amino acids—the Lego blocks for all proteins. The ribosome is an iconic cellular architecture, fused from two main molecular components: RNA and proteins.

Older adults who sleep just five hours a night or fewer have a greater risk of developing more than one chronic disease, new research shows. The findings underscore the importance of healthy sleep patterns throughout life, and especially in middle and old age.

The new study, published in PLOS Medicine, examined sleep duration and its effect on multimorbidity—or the occurrence of more than one chronic condition, like diabetes and cardiovascular disease, at once. People ages 50 or older who slept a total of five hours a night or less were found to have at least a 30% greater risk of multimorbidity.

Prior studies have largely focused on the link between sleep and the development of individual chronic diseases, but it’s been unclear how sleep duration contributes to the development of multiple chronic conditions. The new findings add to growing evidence suggesting that sleep deficiencies can affect health outcomes.

It gives new meaning to the phrase “speak your mind.

Do you remember how legendary cosmologist Stephen Hawking communicated using his special screen-equipped chair? Well, that was a brain-computer interface (BCI), a device that allows a person to communicate using their brain signals.

Continue reading “People with speech paralysis can now talk using this intelligent spelling device” »

“This is the first system that combines all the pieces; efficient energy harvesting, energy storage, and the controlled brain stimulator.”

Researchers have devised an ingenious way to power deep brain simulators — Using the person’s breathing movements.

About 150,000 deep brain stimulators are implanted every year. Normally placed under the skin in the chest area with electrodes implanted in the brain, these stimulators are known to help with neurological and psychiatric diseases when traditional treatments fail.

Turns out, altering bacteria from within could be the solution to antibiotic resistance.

In an ironic twist, researchers used viruses engineered with the CRISPR-Cas system to alter bacterial defense mechanisms and edit their genomes selectively in complex environments. Significantly, the novel approach may help address the pressing issue of antibiotic resistance.

Meletios Verras/iStock.

Continue reading “These engineered viruses are delivering DNA to E.coli instead of killing it- here’s why” »

Digital transformation has been positioned as a cure-all to many of the challenges today’s enterprises face. But to fully reap the benefits of a digital transformation, businesses need to do more than just adopt the latest tools and apps. They also have to change their attitudes, practices and processes around data and technology, throughout their own organization and in their interactions with partners and customers.

“Digital transformation requires a jump on the technology side, but it requires a leap on the people side,” says Bill Gundrey, executive director for digital engineering and operations at Raytheon Missiles & Defense. “At Raytheon, digital transformation is a team sport. It impacts every function in our company, as well as customers and suppliers. We had to change the way people think about data and technology.”

Summary: Mutations of the PTEN gene cause neurons to grow to twice the size and form four times the number of synaptic connections to other neurons as a normal neuron. Removing the RAPTOR gene, an essential gene in the mTORC1 signaling pathway, prevents the neuronal and synaptic overgrowth associated with PTEN mutations. Using Rapamycin to inhibit mTORC1 rescues all the changes in neuronal overgrowth.

Source: the geisel school of medicine at dartmouth.

Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth’s Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the neurobiological basis of autism spectrum disorders (ASD) and pointing to possible treatments.