Lifeboat Foundation

Are online classes the great equalizer?🤣

New psychology findings suggest that attractive students earn higher grades in school, but for female students, this beauty premium disappears when classes are taught remotely. The findings were published in the journal Economic Letters.

A large body of research suggests that physical appearance has an impact on a person’s success. For example, attractive people tend to earn more money and report higher life satisfaction than less attractive people. Interestingly, scholars have yet to agree on the explanation behind this beauty premium.

Continue reading “Attractive female students no longer earned higher grades when classes moved online during COVID-19” »

In a study recently published in the journal Nature Biomedical Engineering, researchers from Kanazawa University use a method called “lasso-grafting” to design therapeutics with enhanced longevity and brain penetration.

Cell growth and repair are stimulated by biomolecules known as cytokines and growth factors. Unfortunately, delivering adequate concentrations of these molecules to the brain for treating neurological conditions like Alzheimer’s disease is challenging as they are either cleared out of the blood very quickly or do not penetrate neural tissue effectively.

A research team led by Kunio Matsumoto and Katsuya Sakai at Kanazawa University in collaboration with Junichi Takagi, Osaka University and Hiroaki Suga, the University of Tokyo has now used a technique called “lasso-grafting” to design molecules that replicate growth factors with longer retention in the body and brain penetration.

Based on marketing activation events the company ran over the summer in Seattle, Austin, and Palo Alto, the outlook for their first product looks pretty rosy. They gave away bags of salad (which were clearly labeled as being gene-edited) consisting of red-and green-leaf mustard greens, and asked people to complete a short survey about it. Adams estimated that more than 6,000 people tried the salads, and over 90 percent responded that they were “very motivated” or “somewhat motivated” to buy the product.

A New Green Revolution?

Continue reading “From Pitless Cherries to Softer Kale, This Startup Is Using CRISPR to Make Better Produce” »

Ribonucleic acid (RNA) is a polymeric molecule similar to DNA that is essential in various biological roles in coding, decoding, regulation and expression of genes. Both are nucleic acids, but unlike DNA, RNA is single-stranded. An RNA strand has a backbone made of alternating sugar (ribose) and phosphate groups. Attached to each sugar is one of four bases—adenine (A), uracil (U), cytosine ©, or guanine (G). Different types of RNA exist in the cell: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA).” RNA is an important information transmitter in our cells and acts as a blueprint for protein production. When freshly formed RNA is processed, introns are removed to produce mature mRNA coding for protein. This cutting is known as “splicing,” and it is controlled by a complex known as the “spliceosome.”

“We found a gene in worms, called PUF60, that is involved in RNA splicing and regulates life span,” says Max Planck scientist Dr. Wenming Huang who made the discovery.

This gene’s mutations resulted in inaccurate splicing and the retention of introns within certain RNAs. As a result, less of the corresponding proteins were produced from this RNA. Surprisingly, worms with the PUF60 gene mutation survived significantly longer than normal worms.

A woman once baffled doctors when she came back to life after being dead for more than 17 hours. Velma Thomas had a heart attack at her home in Virginia in 2008 and was rushed to hospital. While there she had two more heart attacks and was placed on life support — in all, her heart stopped beating three times and she was clinically dead, with no brain activity, for 17 hours.

Two of the first people treated with CAR-T-cell cancer therapies are still in remission 12 years on.

Cas13b can be harnessed to target and degrade RNA transcripts inside a cellular environment. Here the authors reprogram Cas13b to target SARSCoV-2 transcripts in infected mammalian cells and reveal its resilience to variants thanks to single mismatch tolerance.

In Switzerland, cancer is the second-leading cause of death. Non-small cell lung cancer (NSCLC) is the cancer form that kills the most people and is still mostly incurable. Unfortunately, only a small percentage of patients survive the metastatic stage for a long time, and even recently approved therapies can only prolong patients’ lives by a few months. As a result, researchers are looking for innovative cancer treatments. Researchers from the University of Bern and the Insel Hospital identified new targets for drug development for this cancer type in a recent study published in the journal Cell Genomics.

They searched for novel targets in the poorly understood class of genes known as “long noncoding RNAs (Ribonucleic acids)” (lncRNAs). LncRNAs are abundant in the “Dark Matter,” or non-protein-coding DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Knowing that current methods to detect viruses and other biological markers of disease are effective, yet large and expensive (such as fluorescence microscopes), a team of researchers at the University of Tokyo (Tokyo, Japan) has developed and tested a miniaturized virus-scanning system that makes use of low-cost components and a smartphone. The researchers hope the system could aid those who tackle the spread of diseases faster, as current tools—while highly accurate at counting viruses—are too cumbersome for many situations, especially when rapid diagnosis is required.

The newly developed device, which scans biological samples for real viruses, is portable, low-cost, and battery-powered. Yoshihiro Minagawa from the University of Tokyo, who led the development, tested the device with viruses, but says it could also detect other biological markers.

“I wanted to produce a useful tool for inaccessible or less-affluent communities that can help in the fight against diseases such as influenza,” says Minagawa. “Diagnosis is a critical factor of disease prevention. Our device paves the way for better access to essential diagnostic tools.”