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Category: biotech/medical – Page 80

The provincial government of Andhra Pradesh (AP) in India has entered into a Memorandum of Understanding (MoU) with the Gates Foundation to advance the use of technology in various sectors, including healthcare, agriculture, and education. The agreement was discussed in a meeting between AP Chief Minister N. Chandrababu Naidu and Bill Gates, the Foundation’s chair. Naidu reiterated his administration’s dedication to utilizing innovative technology to propel the state’s development.

The MoU focuses on applying technology in ways that will benefit the public, emphasizing affordable and scalable solutions across essential sectors such as healthcare, medical technology, education, and agriculture. According to Naidu, the collaboration will harness the power of artificial intelligence (AI) to enhance predictive health analytics and automate diagnostic processes. In the agricultural sector, AI-based platforms for expert guidance and satellite technology will be employed to optimize farming practices and resource management through precision agriculture techniques.

“This MoU formalises a strategic collaboration in which the Gates Foundation will provide support to implementation partners, co-identified with the AP government, for targeted interventions within state-driven programmes,” Naidu said.

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Research findings focus on people with a sleep disorder, but could have broader implications. For people with a certain sleep disorder, a simple blood test could help predict the development of dementia years before symptoms appear, a new study indicates.

Idiopathic REM sleep behaviour disorder (iRBD) causes people to physically act out their dreams while sleeping.

The disorder is also associated with a very high risk of Parkinson’s disease and a related condition called Dementia with Lewy Bodies.

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A new Science Immunology study shows that disruptions to immunosuppressive intraepithelial lymphocytes and intestinal immunity occurs prior to the onset of chronic ileal inflammation in mouse models of Crohn’s Disease.

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

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The authors show that neuroprotective and neurotoxic astrocytes representional cellular substates present during neuroinflammation and that targeting mTOR in astrocytes reduces neurotoxicity, suggesting a potential therapeutic strategy for neurodegenerative diseases.

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They found that increased Hh signaling is a hallmark of human meibomian gland carcinoma, a rare and aggressive cancer of the eyelid. Furthermore, the team discovered that aged glands show decreased Hh signaling and decreased epidermal growth factor receptor (EGFR) signaling, as well as impaired innervation and a loss of collagen in niche fibroblasts, suggesting that changes in both glandular epithelial cells and their surrounding microenvironment contribute to age-related degeneration.

These discoveries suggest that targeting Hh and EGFR signaling to stimulate stem cell activity in the meibomian glands could be a potential therapeutic option to treat evaporative dry eye disease.

A team of researchers has identified stem cell populations and mechanisms underlying age-related degeneration in glands that are vital to eye function. The findings, published in Nature Communications, may lead to new therapeutic approaches for evaporative dry eye disease, a common condition in older people.

Meibomian glands, tiny oil glands along the edges of the eyelids, secrete lipid-rich meibum to prevent tear evaporation and protect the eye surface. Aging-related shrinkage of the meibomian glands may result, in part, from stem cell exhaustion and is associated with evaporative dry eye disease, a common condition that causes swollen eyelids, itchy eyes, or blurred vision. Symptoms may be lessened with warm compressions, artificial tears, and thermal pulsation, but these treatments are only partially effective.

The researchers identified markers for stem cell populations that maintain distinct regions of the meibomian glands, and uncovered the hedgehog (Hh) cell-cell signaling pathway, which is broadly important in development and disease, as a key regulator of meibomian gland stem cell proliferation and tissue regeneration.

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Superconductivity is a quantum physical state in which a metal is able to conduct electricity perfectly without any resistance. In its most familiar application, it enables powerful magnets in MRI machines to create the magnetic fields that allow doctors to see inside our bodies. Thus far, materials can only achieve superconductivity at extremely low temperatures, near absolute zero (a few tens of Kelvin or colder).

But physicists dream of superconductive materials that might one day operate at room temperature. Such materials could open entirely new possibilities in areas such as , the energy sector, and medical technologies.

“Understanding the mechanisms leading to the formation of superconductivity and discovering exotic new superconducting phases is not only one of the most stimulating pursuits in the fundamental study of quantum materials but is also driven by this ultimate dream of achieving room-temperature superconductivity,” says Stevan Nadj-Perge, professor of applied physics and materials science at Caltech.

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Accurate and robust 3D imaging of specular, or mirror-like, surfaces is crucial in fields such as industrial inspection, medical imaging, virtual reality, and cultural heritage preservation. Yet anyone who has visited a house of mirrors at an amusement park knows how difficult it is to judge the shape and distance of reflective objects.

This challenge also persists in science and engineering, where the accurate 3D imaging of specular surfaces has long been a focus in both optical metrology and computer vision research. While specialized techniques exist, their inherent limitations often confine them to narrow, domain-specific applications, preventing broader interdisciplinary use.

In a study published in the journal Optica, University of Arizona researchers from the Computational 3D Imaging and Measurement (3DIM) Lab at the Wyant College of Optica l Sciences present a novel approach that significantly advances the 3D imaging of specular surfaces.

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For the first time, researchers have shown that terahertz imaging can be used to visualize internal details of the mouse cochlea with micron-level spatial resolution. The non-invasive method could open new possibilities for diagnosing hearing loss and other ear-related conditions.

“Hearing relies on the , a spiral-shaped organ in the inner ear that converts sound waves into neural signals,” said research team leader Kazunori Serita from Waseda University in Japan. “Although conventional imaging methods often struggle to visualize this organ’s fine details, our 3D terahertz near-field imaging technique allows us to see small structures inside the cochlea without any damage.”

Terahertz radiation, which falls between microwaves and the mid-infrared region of the electromagnetic spectrum, is ideal for biological imaging because it is low-energy and non-harmful to tissues, scatters less than near-infrared and visible light and can pass through bone while also being sensitive to changes in hydration and cellular structure.

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