Posted in biotech/medical, food
Long suspected to exist, cancer stem cells were discovered in solid tumors about 20 years ago. Is this the long-sought root cause of cancer? Thousands of scientists now believe so. Then why haven’t you heard about this from your oncologist? We delve into the debate on CSCs, and explore which foods and food supplements are most effective in the lab at killing or blocking cancer stem cells.
Treated participants’ risk of heart attack or stroke dropped by 58%.
The trial: Mesoblast has now tested the therapy, called “rexlemestrocel-L,” in a double-blind, randomized phase 3 trial, which it says is the largest trial of a cell therapy in patients with chronic heart failure. The results have been published in the Journal of the American College of Cardiology.
During this trial, 537 patients with HFrEF received an injection of about 150 million MPCs straight into the muscular tissue of their hearts — or a sham treatment with no injection. All of the participants were also receiving standard heart failure treatment at the time of the trial.
JAMA Network Open commentary focuses on the relationship of pain, depression, and anxiety.
Chronic pain is often accompanied by depression and anxiety. In an invited commentary published in JAMA Network Open, Kurt Kroenke, M.D., of Regenstrief Institute and Indiana University School of Medicine, discusses the relationship between pain, the most common symptom for which individuals visit a physician, and depression and anxiety, the two most prevalent mental health conditions worldwide. He highlights the importance of not neglecting psychological symptoms in patients experiencing pain.
Understanding the Connection.
A collaborative research team has developed a method to connect lab-grown brain tissues, enhancing the understanding of brain development and functions, and paving the way for potential advancements in treating neurological conditions.
The idea of growing a functioning human brain-like tissues in a dish has always sounded pretty far-fetched, even to researchers in the field. Towards the future goal, a Japanese and French research team has developed a technique for connecting lab-grown brain-mimicking tissue in a way that resembles circuits in our brain.
Advancements in Neural Studies.
EPFL researchers have developed GEMLI, a pioneering tool that could democratize and vastly improve how we study the journey of cells from their embryonic state through to specialized roles in the body, as well as their changes in cancer and other diseases.
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Study explores the differences in gut microbiome composition between prediabetic patients and healthy individuals, revealing significant variations that correlate with altered metabolic functions and potential diabetes progression.
Anyone who needs an unusual mole on their skin checked out may soon get to skip a surgical biopsy, and instead have a virtual biopsy. This tool could be a quick, uninvasive way to identify cancerous cells, as well as reveal any cancerous tissue that might be present and left behind during a surgery. This new tool uses lasers to and generate a three-dimensional reconstruction of cells in a tissue under analysis. Cross-sectional images of that tissue can then be assessed, like slides on a microscope. This work may one day be used not only on skin, but on other parts of the body. The work has been reported in Science Advances.
“We’ve not only created something that can replace the current gold-standard pathology slides for diagnosing many conditions, but we actually improved the resolution of these scans so much that we start to pick up information that would be extremely hard to see otherwise,” said senior study author Adam de la Zerda, PhD, an associate professor of structural biology at Stanford University.
Nanomaterials manufacturing, 3D bioprinting, and astronaut eye health were the main research topics aboard the International Space Station on Friday. The Expedition 71 crew members also continued servicing spacesuits and conducted an emergency drill.
The SpaceX Dragon cargo spacecraft recently delivered to the orbital outpost a biotechnology study to demonstrate the in-space production of nanomaterials that mimic DNA. NASA Flight Engineers Jeanette Epps and Mike Barratt worked on the second portion of that experiment on Thursday mixing then treating the research samples for analysis. Epps began her day mixing solutions in the Life Science Glovebox to create specialized nanomaterials. During the afternoon, Barratt applied sound and light treatments to the samples then stowed them aboard Dragon for analysis back on Earth. Results may lead to advanced therapies for space-caused and Earthbound health conditions.
The duo partnered back together at the end of the day for eye scans using standard medical imaging gear found in an optometrist’s on Earth. Barratt operated the hardware with guidance from doctors on the ground peering into Epp’s eyes and examining her retina and optic nerve for the B Complex eye health investigation.
We depend on our cells being able to divide and multiply, whether it’s to replace sunburnt skin or replenish our blood supply and recover from injury. Chromosomes, which carry all of our genetic instructions, must be copied in a complete way during cell division. Telomeres, which cap the ends of chromosomes, play a critical role in this cell-renewal process—with a direct bearing on health and disease.
“This study is a first step in uncovering how we can mitigate risks of THC when used in medicine, and also is targeted at making cannabis safer for the general, non-therapeutic consumer,” said Dr. Tory Spindle.
Can cannabis be modified to decrease certain side effects, specifically anxiety, that is caused by tetrahydrocannabinol (THC)? This is what a recent study published in Drug and Alcohol Dependence hopes to address as a team of researchers led by the Johns Hopkins University School of Medicine investigated whether adding d-limonene, which is a known cannabis oil, to THC could help alleviate common feelings of anxiety or paranoia that cannabis users traditionally experience. This study holds the potential to help improve medicinal cannabis while decreasing risks to users of recreational cannabis, as well.
For the study, the researchers enlisted 20 healthy adult participants with an average age of 26 years old who completed 10 six-hour sessions involving them using vaporized THC alone (15 mg or 30 mg), vaporized d-limonene alone (1 mg or 5 mg), both together, and finally a placebo. The sessions were double-blinded, meaning both the researchers and participants were unaware who was vaporizing which sample.
While all 20 participated in nine sessions, 12 participants conducted the tenth session comprised of the higher dose of THC and an even higher dose of d-limonene at 15 mg. The goal of the sessions was to ascertain the overall drug effects, specifically vital signs, mood, and cognitive functions, along with blood and urine samples during and after each session to measure THC and d-limonene levels.
