Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 432

By Ariana Mendible

For the past several years, I have been closely involved with the Institute for the Quantitative Study of Inclusion, Diversity and Equity (QSIDE). This nonprofit organizes events and facilitates research in quantitative justice, the application of data and mathematical sciences to quantify, analyze and address social injustice. It uses the community-based participatory action research model to connect like-minded scholars, community partners, and activists together. Recently, QSIDE researchers met virtually in a Research Roundup to share our progress. Hearing all the incredible work that QSIDE has spawned and supported prompted me to reflect on the role that the group has played in my budding career and the ways in which the institute itself has grown since its founding in 2019.

Like many PhD candidates, my final year of graduate school was rife with burnout and uncertainty about post-graduation plans. Add to this mix a global pandemic, social isolation, and confinement to the same one-bedroom dwelling for the last year plus and you get a stew of anxiety. I was approaching my mental limit on the research I had been conducting, somewhere at the intersection of data science and fluid dynamics. While the problem I had been working on for my thesis was interesting, I was ready for a major change. I couldn’t picture myself in the usual post-graduate tracks: a post-doc at an R1 institution or working for a Big Tech company. These careers felt hyper-competitive, a turn-off during a period of significant burnout. I also couldn’t see their direct positive impact, which felt acutely important in this time of global social disarray.

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Thin lips are a common cosmetic concern for people with scleroderma – and can impact a patient’s ability to chew, swallow, and sleep.

Writing in the Journal of the American Academy of Dermatology, a YSM team finds hyaluronic acid lip fillers are a safe and effective option.

Hyaluronic acid lip fillers are safe and effective for patients with systemic sclerosis, or scleroderma, a new Yale study finds.

Thin lips are not only a common cosmetic concern in patients with scleroderma, a condition that involves tightening and hardening of the skin among other effects on internal organs, but also can impact a person’s ability to chew, swallow, and sleep. In addition, the condition can be stigmatizing and have significant psychosocial impacts. Although hyaluronic acid fillers are commonly used in the restoration of lip volume, they have not been used routinely in patients with the disease due to concerns of worsening the autoimmune condition.

Researchers in Yale’s Department of Dermatology and Internal Medicine’s Section of Rheumatology, Allergy and Immunology published their findings in the Journal of the American Academy of Dermatology. They conducted a prospective study of seven patients with systemic sclerosis and perioral involvement to evaluate the safety and efficacy of these fillers in this patient population. Among the various types of cosmetic lip filler, the team chose Restylane® Silk (Galderma) a hyaluronic acid filler with low cross-linking, hypothesized to have lower immunogenicity.

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Bioelectrical signaling in the African clawed frog modulates both resistance to infection and tail regeneration. Michael Levin at Tufts University in Massachusetts, USA, and colleagues have used genetic technologies and drug treatments to manipulate the bioelectrical properties of tissues in frog embryos. Reducing the electric gradient between the inside and outside of cells (depolarization) increased the embryos’ survival rate to bacterial infection, whereas increasing the resting potential (hyperpolarization) had the opposite effect. The authors found that serotonergic signaling and an increase in the number of myeloid cells underpin depolarization-induced immunity. Interestingly, embryos undergoing tail regeneration, which triggers depolarization, also showed increased resistance to infection.

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Researchers at the University of Bayreuth have developed a new method for controlling the growth of physical micro-runners. They used an external magnetic field to assemble paramagnetic colloidal spheres—i.e. only magnetic due to external influences—into rods of a certain length. Colloidal particles are tiny particles in the micro-or nanometer range that can be used in medicine as carriers of biochemicals.

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Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than the industry standard, CRISPR, which has revolutionized genetic engineering in medicine, agriculture and biotechnology.

SeekRNA uses a programmable ribonucleic acid (RNA) strand that can directly identify sites for insertion in genetic sequences, simplifying the editing process and reducing errors.

The new gene-editing tool is being developed by a team led by Dr. Sandro Ataide in the School of Life and Environmental Sciences. Their findings have been published in Nature Communications.

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In a new study, lab mice given an experimental drug were jokingly referred to as “supermodel grannies” because they looked so youthful even while aging beyond their expected lifespan.

As the BBC reports, the trials for a drug believed to flush out a protein known as interleukin-11 — which in early development helps build our bones but later in life causes the kinds of inflammation that triggers much of the illness of aging — have already had intriguing success in mice.

Published in the journal Nature, a paper about the research undertaken by scientists at Imperial College London, Duke-NUS in Singapore, and the MRC Lab of Medical Sciences found that when given a drug that purges interleukin-11, the mice became more lean, had healthier fur, and had significantly lower levels of cancer than their counterparts of the same age.

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