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Category: biotech/medical – Page 429

Researchers have discovered the process by which dietary choline crosses the blood-brain barrier. This breakthrough has potential applications in enhancing drug delivery to the brain for treating neurological disorders.

A researcher from the University of Queensland has identified molecular doorways that could facilitate the delivery of drugs to the brain for treating neurological disorders.

Dr. Rosemary Cater from UQ’s Institute for Molecular Bioscience led a team that discovered that an essential nutrient called choline is transported into the brain by a protein called FLVCR2.

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Most antibiotics target metabolically active bacteria, but with artificial intelligence, researchers can efficiently screen compounds that are lethal to dormant microbes.

Since the 1970s, modern antibiotic discovery has been experiencing a lull. Now the World Health Organization has declared the antimicrobial resistance crisis as one of the top 10 global public health threats.

When an infection is treated repeatedly, clinicians run the risk of bacteria becoming resistant to the antibiotics. But why would an infection return after proper antibiotic treatment? One well-documented possibility is that the bacteria are becoming metabolically inert, escaping detection of traditional antibiotics that only respond to metabolic activity. When the danger has passed, the bacteria return to life and the infection reappears.

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A study in Nature identifies molecular responses to endurance exercise training in rats, including sex-specific responses. The findings may offer new insights into the impact of exercise on health and disease. Read the paper:

Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

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A research team at the University of Pittsburgh led by Alexander Star, a chemistry professor in the Kenneth P. Dietrich School of Arts and Sciences, has developed a fentanyl sensor that is six orders of magnitude more sensitive than any electrochemical sensor for the drug reported in the past five years. The portable sensor can also tell the difference between fentanyl and other opioids.

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Hvidovre Hospital has the world’s first prototype of a sensor capable of detecting errors in MRI scans using laser light and gas. The new sensor, developed by a young researcher at the University of Copenhagen and Hvidovre Hospital, can thereby do what is impossible for current electrical sensors—and hopefully pave the way for MRI scans that are better, cheaper and faster.

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The following is a summary of “Comparative Effectiveness of Partial Gland Cryoablation Versus Robotic Radical Prostatectomy for Cancer Control,” published in the April 2024 issue of Urology by Zhu et al.

In this study, researchers address the notable gap in high-level evidence comparing oncologic endpoints for partial gland ablation, where most existing series rely on prostate-specific antigen (PSA) rather than biopsy endpoints. The objective was to conduct a comprehensive comparison of oncologic outcomes between partial gland cryoablation (PGC) and radical prostatectomy (RP) for the management of prostate cancer.

Through a retrospective, single-center analysis, investigators examined a cohort of subjects treated with either PGC (n = 98) or RP (n = 536) as primary treatment for intermediate-risk (Gleason grade group [GG] 2–3) prostate cancer between January 2017 and December 2022. Key oncologic endpoints included surveillance biopsies per protocol after PGC and serial PSA testing after RP. The primary outcome of interest was treatment failure, which is defined as the necessity for salvage treatment or metastatic disease development. The study group conducted treatment failure and survival analyses using Cox proportional-hazard regression and Kaplan-Meier survival curves. After carefully applying inclusion/exclusion criteria, they compared the PGC (n = 75) and RP (n = 298) groups.

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