A recent study challenges the effectiveness of microdosing LSD for treating ADHD. Despite self-reported improvements, the clinical trial found no significant difference between low-dose LSD and placebo in reducing ADHD symptoms.
Category: biotech/medical – Page 350
Deconvoluting the interplay of innate and adaptive immunity in BCG-induced nonspecific and TB-specific host resistance
Normal glucose regulation (NGR) for prediabetes remission.
Prediabetes remission to normal glucose regulation (NGR), in addition to standard weight loss, lowers type 2 diabetes (T2D) risk more than standard weight loss alone.
Remission of prediabetes to NGR should be considered in guidelines and recommendations for the delay and prevention of T2D.
Future studies will provide evidence whether or not prediabetes remission can protect against incident T2Drelated comorbidities such as cardiovascular and/or chronic kidney disease (CKD). https://sciencemission.com/Prediabetes-remission
Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals at risk for diabetes are associated with both specific risk profiles for progression and a differential potential to facilitate prediabetes remission and reduce the risk of future T2D. This review examines the current definition and global prevalence of prediabetes and evaluates the potential of prediabetes remission to reduce the alarming increase in the global burden of T2D.
Scientists witness living plant cells generate cellulose and form cell walls for the first time
In a groundbreaking study on the synthesis of cellulose—a major constituent of all plant cell walls—a team of Rutgers University-New Brunswick researchers have captured images of the microscopic process of cell-wall building continuously over 24 hours with living plant cells, providing critical insights that may lead to the development of more robust plants for increased food and lower-cost biofuels production.
The discovery, published in the journal Science Advances, reveals a dynamic process never seen before and may provide practical applications for everyday products derived from plants, including enhanced textiles, biofuels, biodegradable plastics, and new medical products.
The research is also expected to contribute to the fundamental knowledge while providing a new understanding of the formation of cell walls, the scientists said.
Neura Robotics bets on 4NE-1 humanoid robot to compete with China
Neura Robotics has built a diverse portfolio of robots, including MAiRA, the world’s first cognitive cobot. MAiRA uses artificial intelligence for autonomous operation and safe human interaction. The company also offers the MAV, a mobile robot for heavy load transport, and MiPA, a humanoid robot designed for tasks like serving trays in hospitals.
Through its cloud-based Neuraverse platform, Neura also creates cutting-edge software, in contrast to many robotics companies that only concentrate on hardware. Known as an “ecosystem for cognitive robotics,” the Neuraverse is a marketplace for robotic abilities and an operating system designed to spur innovation.
Many businesses displayed humanoid robots at CES 2025, demonstrating the momentum of the robotics sector. The humanoid robot “Melody,” created by Realbotix, is simple to assemble and disassemble. In the meantime, the full-size bipedal humanoid robot known as the “CASBOT 01” was introduced by China’s Lingbao CASBOT.
New Monoclonal Antibodies Specific for Different Epitopes of the Spike Protein of SARS-CoV-2 and Its Major Variants: Additional Tools for a More Specific COVID-19 Diagnosis
The emergence of the new pathogen SARS-CoV-2 determined a rapid need for monoclonal antibodies (mAbs) to detect the virus in biological fluids as a rapid tool to identify infected individuals to be treated or quarantined. The majority of commercially available antigenic tests for SARS-CoV-2 rely on the detection of N antigen in biologic fluid using anti-N antibodies, and their capacity to specifically identify subjects infected by SARS-CoV-2 is questionable due to several structural analogies among the N proteins of different coronaviruses. In order to produce new specific antibodies, BALB/c mice were immunized three times at 20-day intervals with a recombinant spike (S) protein. The procedure used was highly efficient, and 40 different specific mAbs were isolated, purified and characterized, with 13 ultimately being selected for their specificity and lack of cross reactivity with other human coronaviruses. The specific epitopes recognized by the selected mAbs were identified through a peptide library and/or by recombinant fragments of the S protein. In particular, the selected mAbs recognized different linear epitopes along the S1, excluding the receptor binding domain, and along the S2 subunits of the S protein of SARS-CoV-2 and its major variants of concern. We identified combinations of anti-S mAbs suitable for use in ELISA or rapid diagnostic tests, with the highest sensitivity and specificity coming from proof-of-concept tests using recombinant antigens, SARS-CoV-2 or biological fluids from infected individuals, that represent important additional tools for the diagnosis of COVID-19.
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs
Now online!This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement and its regulation by non-degradative polyubiquitination within the tumor microenvironment. The findings highlight LAG3/CBL coexpression as a promising biomarker for selecting suitable patients for LAG3-targeted immunotherapy.
