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Category: biotech/medical – Page 349

Gene-editing nanoparticle system targets multiple organs simultaneously

A gene-editing delivery system developed by UT Southwestern Medical Center researchers simultaneously targeted the liver and lungs of a preclinical model of a rare genetic disease known as alpha-1 antitrypsin deficiency (AATD), significantly improving symptoms for months after a single treatment, a new study shows. The findings, published in Nature Biotechnology, could lead to new therapies for a variety of genetic diseases that affect multiple organs.

“Multi-organ diseases may need to be treated in more than one place. The development of multi-organ-targeted therapeutics opens the door to realizing those opportunities for this and other diseases,” said study leader Daniel Siegwart, Ph.D., Professor of Biomedical Engineering, Biochemistry, and in the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern.

Gene editing—a group of technologies designed to correct disease-causing mutations in the genome—has the potential to revolutionize medicine, Dr. Siegwart explained. Targeting these technologies to specific organs, tissues, or will be necessary to effectively and safely treat patients.

Artificial neural networks reveal how peripersonal neurons represent the space around the body

The brains of humans and other primates are known to execute various sophisticated functions, one of which is the representation of the space immediately surrounding the body. This area, also sometimes referred to as “peripersonal space,” is where most interactions between people and their surrounding environment typically take place.

Researchers at Chinese Academy of Sciences, Italian Institute of Technology (IIT) and other institutes recently investigated the neural processes through which the brain represents the area around the body, using brain-inspired computational models. Their findings, published in Nature Neuroscience, suggest that receptive fields surrounding different parts of the body contribute to building a modular model of the space immediately surrounding a person or (AI) agent.

“Our journey into this field began truly serendipitously, during unfunded experiments done purely out of curiosity,” Giandomenico Iannetti, senior author of the paper, told Medical Xpress. “We discovered that the hand-blink reflex, which is evoked by electrically shocking the hand, was strongly modulated by the position of the hand with respect to the eye.

Herpes virus reshapes the human genome for its own benefit, but a single enzyme can stop it

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the host’s cellular machinery to make new copies of themselves. Herpes simplex virus-1 (HSV-1), it turns out, also redecorates, according to a study in Nature Communications.

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have discovered the cold sore reshapes the human genome’s architecture, rearranging its shape in three-dimensional space so that HSV-1 can access host genes most useful for its ability to reproduce.

“HSV-1 is an opportunistic interior designer, reshaping the human genome with great precision and choosing which bits it comes into contact with. It’s a novel mechanism of manipulation we didn’t know the virus had to exploit host resources,” says Dr. Esther González Almela, first author of the study.

New all-silicon computer vision hardware advances in-sensor visual processing technology

Researchers at the University of Massachusetts Amherst have pushed forward the development of computer vision with new, silicon-based hardware that can both capture and process visual data in the analog domain. Their work, described in the journal Nature Communications, could ultimately add to large-scale, data-intensive and latency-sensitive computer vision tasks.

“This is very powerful retinomorphic hardware,” says Guangyu Xu, associate professor of electrical and engineering and adjunct associate professor of biomedical engineering at UMass Amherst. “The idea of fusing the sensing unit and the processing unit at the device level, instead of physically separating them apart, is very similar to the way that process the visual world.”

Existing computer vision systems often involve exchanging redundant data between physically separated sensing and computing units.

Scientists Say Humans May Become Immortal by 2050 Here’s How

Will humans soon live forever? Scientists believe it’s possible — and it could happen as early as 2050.
In this video, we explore 10 shocking scientific breakthroughs that are pushing humanity closer to immortality.
From nanobots that cure disease from within, to brain uploading, cloning organs, and AI-driven consciousness — this is the future of life itself.

🧬 Get ready to discover the jaw-dropping technologies that might just make death optional.

⚠️ Don’t blink. The future is coming faster than you think.

Palm-sized device detects disease markers in under 45 minutes without additional lab equipment

Scientists from the National University of Singapore (NUS) have developed NAPTUNE (Nucleic Acids and Protein biomarkers Testing via Ultra-sensitive Nucleases Escalation), a point-of-care assay that identifies trace amounts of disease-related genetic material, including nucleic acid and protein markers, in less than 45 minutes. Importantly, it accomplished this without the need for laboratory equipment or complex procedures.

Lying at the heart of many modern diagnostics, (PCR) and real-time immunoassays provide high accuracy. However, they are hindered by lengthy processing time, the need for specialized thermal cyclers and skilled personnel. These constraints hamper rapid outbreak management, early cancer screening and bedside decision-making, especially in low-resource settings.

NAPTUNE tackles these challenges by replacing bulky amplification steps with a tandem nuclease cascade that converts biological signals directly into readily detectable DNA fragments, streamlining the diagnostic process.

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