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Category: biotech/medical – Page 353
Nasal nanomedicine delivers immune-boosting therapy to fight brain tumors
Researchers at Washington University School of Medicine in St. Louis, along with collaborators at Northwestern University, have developed a noninvasive approach to treat one of the most aggressive and deadly brain cancers. Their technology uses precisely engineered structures assembled from nano-size materials to deliver potent tumor-fighting medicine to the brain through nasal drops. The novel delivery method is less invasive than similar treatments in development and was shown in mice to effectively treat glioblastoma by boosting the brain’s immune response.
Type 1 Diabetes Cured in Mice Given Experimental Hybrid Treatment
A specially devised hybrid treatment has shown tremendous potential for treating type 1 diabetes in mice, scoring full marks at preventing the condition in prediabetic animals and at reversing the condition in animals with fully developed diabetes.
What makes the new approach stand out is that it successfully combines immune system cells from both the patient mouse and a donor mouse, encouraging them to live in harmony without a need for immunosuppressive drugs for at least four months.
The researchers behind the work, led by a team from the Stanford School of Medicine, are hopeful the same approach could be successful in humans too. The treatment might also have potential for other procedures where transplants are required.
Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease: A Nonrandomized Clinical Trial
Long-term adaptive deep brain stimulation (aDBS) provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving continuous DBS.
Question Is long-term adaptive deep brain stimulation (aDBS) tolerable and as effective and safe as continuous DBS (cDBS)?
Findings In this nonrandomized clinical trial with an open-label comparison between cDBS and aDBS, the primary outcome was met as the majority of participants receiving aDBS achieved a performance goal of good on-time (ie, time when symptoms were well controlled) without troublesome dyskinesia relative to stable cDBS therapy.
Meaning Long-term aDBS provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving cDBS.
Single-dose radiation before surgery can eradicate breast cancer
A single, targeted high dose of radiation delivered before other treatments could completely eradicate tumors in most women with early-stage, operable hormone-positive breast cancer, according to a study led by UT Southwestern Medical Center researchers. The findings, published in JAMA Network Open, could shift the paradigm for patients with the most common form of breast cancer, who typically undergo surgery before a regimen of radiation therapy.
“This is a major advance in the field,” said study leader Asal Rahimi, M.D., Professor of Radiation Oncology, Associate Vice Chair for Program Development, and Medical Director of the Clinical Research Office at the Harold C. Simmons Comprehensive Cancer Center. “This treatment protocol provides patients a significant time savings, spares a lot of their tissue from irradiation, and allows them to still undergo any type of oncoplastic surgery they may choose, all while very effectively treating their disease.”
Dr. James Giordano: The Brain is the Battlefield of the Future
Dr. James Giordano, Chief of the Neuroethics Studies Program and Scholar-in-Residence in the Pellegrino Center for Clinical Bioethics at Georgetown University, speaks to cadets and faculty about how advancements in neuroscience and neurotechnology will impact the future of war. This event was hosted by the Modern War Institute at West Point.
Peace lily: why leaves turn brown and how to fix it, according to experts
It’s not random.
The Spathiphyllum is forgiving, but it signals stress fast. Brown patches and crunchy tips are a nudge from the plant about its air, water, or light. Here’s how specialists diagnose those signals and the small adjustments that bring foliage back to lush green.
Brown on a peace lily is usually a care mismatch, not a fatal disease. The plant is reacting to dry air, irregular watering, hard tap water, or harsh sun. Each cause marks leaves a little differently, which helps you zero in on the fix.