Background and ObjectivesN-acetyl-l-leucine (NALL) has been established to improve the neurologic manifestations of Niemann-Pick disease type C (NPC) after 12 weeks in a placebo-controlled trial. In the open-label extension phase (EP) follow-up, data were…
Category: biotech/medical – Page 296
Mimicking the benefits of exercise with a single molecule
Capital Medical University, in collaboration with the Chinese Academy of Sciences, reports that betaine, a molecule produced in the kidney and enhanced through sustained exercise, operates as a potent inhibitor of inflammatory and aging-related pathways.
Regular physical activity boosts health across cardiovascular, metabolic, and neurological systems. Scientists have traced improvements in immune function, insulin sensitivity, clearing of senescent cells and tissue regeneration to consistent physical activity. Earlier animal studies suggested that long-term exercise can delay aging processes and reduce vulnerability to chronic disease.
Precise molecular explanations for how sustained exercise reshapes human biology remain incomplete. Many investigations have focused on single biomarkers or isolated tissues, leaving a need for systematic maps that can connect exercise to measurable physiological benefits. Specific factors capable of mimicking exercise’s protective effects without requiring continuous physical exertion have remained unclear.
Blood stem cell mutations linked to lower risk of late-onset Alzheimer’s disease
A study published in Cell Stem Cell reveals that some mutations in blood stem cells might help protect against late-onset Alzheimer’s disease.
A team led by researchers at Baylor College of Medicine discovered that both a mouse model and people carrying blood stem cells with mutations in the gene TET2, but not in the gene DNMT3A, had a lower risk of developing Alzheimer’s disease. Their study proposes a mechanism that can protect against the disease and opens new avenues for potential strategies to control the emergence and progression of this devastating condition.
“Our lab has long been studying blood stem cells, also called hematopoietic stem cells,” said lead author Dr. Katherine King, professor of pediatrics— infectious diseases and a member of the Center for Cell and Gene Therapy and the Dan L Duncan Comprehensive Cancer Center at Baylor. She is also part of Texas Children’s Hospital.
Wearable X-ray-detecting fabric offers a flexible alternative to current imaging tech
Since their discovery by Wilhelm Roentgen in 1895, X-rays have become a staple of modern medical care, from imaging teeth and broken bones to screening for the early signs of breast cancer.
The most common type of X-ray detector used in medical imaging today utilizes materials known as scintillators, which are made of inorganic and rigid compounds. This inherent lack of flexibility limits their applications and often requires patients to contort their bodies to accommodate unyielding medical equipment.
This rigidity has created a demand among researchers and the medical community for scintillating materials that are robust, efficient, and flexible. Past attempts to meet this demand, however, have had to sacrifice durability and efficiency for flexibility. An innovative fabric made of flexible inorganic fibers shows remarkable promise and may meet all three requirements.
