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Liz Parrish on Therapies to Slow and Reverse the Effects of Aging

Excellent lightning round questions below the audio. Between Dune and Hitchhikers Guide, Liz is indeed a nerd.


In this episode we talk about aging. It’s a condition that everyone experiences and indeed, one thing is certain: when it comes to aging, our condition is terminal. Our guest today is challenging that and fighting aging head on. We’re speaking with Liz Parrish, the CEO of BioViva, a biotech company dedicated to advancing gene and cell therapies to treat the diseases of aging. We dive into her work and learn about the results of the treatment that she received to slow and maybe even reverse the effects of aging.

Liz is a passionate advocate for patient access to these revolutionary treatments, and a couple years ago, Liz decided to take her own medicine – literally. In September 2015, Liz underwent genetic therapy with the aim of slowing and even reversing the effects of aging. She believes that aging should be classified as a disease to open up entirely new and untapped pathways to extend human lives and allow us to be healthier, longer.

Gene therapy to treat aging as a disease. Is this something that will catch on? Should we be tinkering with our own genes in this way? If not, why not? We’re already extending the lives of animals from earthworms to mice – why shouldn’t we work to extend our own lives through applying this technology? But if we do that, will these treatments only be available to the elite and wealthy of our society, or is this something that can benefit all of society by making it available to anyone who wants it?

New CRISPR improvement allows multiple gene edits and better accuracy

Researchers at the Scripps Research Institute Florida campus have refined the already state-of-the-art gene-editing system CRISPR. The new improvements boost the ability of CRISPR to target, cut and paste genes in human and animal cells and helps to address the concerns of off target gene mutations raised in a recent study [1].

What is CRISPR?

CRISPR is short for “Clustered Regularly Interspaced Short Palindromic Repeat,” and is a gene editing system that exploits an ancient bacterial immune defense process. Some microbes combat viral infection by sequestering a piece of a virus’ foreign genetic material within its own DNA, to serve as a template. The next time the viral sequence is encountered by the microbe, it is detected immediately and cut up for disposal with the help of two types of RNA. Molecules called guide RNAs show the location of the invader, and the CRISPR effector proteins act as the scissors that cut it apart and destroy it.

The Elite Want to Transfer Consciousness Into a New Body and Live Forever

A conspiracy theory article that I think is spreading semi-fake news (but it’s interesting to see how some people react to #transhumanism):


While the title of this article may sound like it belongs on a strange and dark science fiction movie, it doesn’t. Unfortunately, it seems that as the technological world continues to advance, the more the old adage ‘the truth is stranger than fiction’ becomes true.

Throughout the past year or so, we have heard Google’s leading futurist tell us that it will one day be possible to live forever. His belief is that it will start with nanobots in the human body which would work to defeat deadly disease, in place of our immune system. Kurzweil maintains that the human immune system is inadequate and that,

“Your immune system, for example, does a poor job on cancer,” he told Playboy.” It thinks cancer is you. It doesn’t treat cancer as an enemy. It also doesn’t work well on retroviruses. It doesn’t work well on things that tend to affect us later in life because it didn’t select for longevity.”

He also believes that the nanobots will enhance humanity and bring us to a point we could never have reached on our own. “We’re going to be funnier. We’re going to be sexier. We’re going to be better at expressing loving sentiment.”

Didier Coeurnelle – Life Extension and Existential Risks

Another LEAF interview from the International Longevity and Cryopreservation Summit in Madrid with Didier Coeurnelle of Heales.


LEAF director Elena Milova was recently at the International Longevity and Cryopreservation Summit in Madrid. During the conference she caught up with life extension advocate Didier Coeurnelle.

In this interview Didier discusses his projects and shares advice to the community regarding what kind of activities can help foster progress in the development of rejuvenation biotechnology.

Didier is one of the most active members of the European life extension community, co-president of HEALES (Healthy Life Extension Society), vice-president of French Transhumanist Association Technoprog, and a founding member of the International Longevity Alliance. He is also a long-term member of the local ecology movement. Didier is currently a lawyer in a Belgian federal government agency for social security. Didier is the main organizer of the biennial scientific conference Eurosymposium on Healthy Ageing, held in Brussels, Belgium.

This Tattoo Changes Colors As Your Blood Sugar Levels Change

Whether or not you like tattoos (or have one yourself), you’ll have to admit—these are pretty cool. Scientists have developed something called a “biosensing” tattoo that could help change the lives of people living with types 1 or 2 diabetes. How could a tattoo do this, you ask? Well, by changing color along with the person’s blood sugar levels.

This new tattoo is the hard work of a team of researchers from Harvard and MIT who call the project Dermal Abyss. The researchers replaced traditional tattoo ink with color-changing “biosensors” that react to variations in the interstitial fluid, which surrounds tissue cells in the human body.

“It blends advances in biotechnology with traditional methods in tattoo artistry,” the team writes on their website. “Currently… diabetics need to monitor their glucose levels by piercing the skin, 3 to 10 times per day. With Dermal Abyss, we imagine the future where the painful procedure is replaced with a tattoo. Thus, the user could monitor the color changes and the need of insulin.”

Head Transplant Doctor Reports Successful Repair of Spinal Cord in Rats

A head transplant doctor claims to have made advance toward realizing the medical procedure, but the scientific community remains skeptical. The team claims to have used a proprietary “glue” to repair the severed spines of rats and achieved full recovery.

Sergio Canavero, a man who has made the goal of his life’s work to transplant a human head onto a donor body, is claiming a success. He and his team have reported seemingly positive results from a technique called the Gemini Protocol. They used the protocol to repair severed spinal cords in rats, and their findings indicate that their methodology works “across the board.”

LEAF Panel: How to Promote Longevity? ft. Drs. Aubrey de Grey, Alexandra Stolzing, Oliver Medvedik

On the 9th of June we teamed up with the Major Mouse Testing Program (MMTP) for a live stream longevity panel on the MMTP Facebook page. The panel included Dr. Alexandra Stolzing, Dr. Aubrey de Grey, Dr. Oliver Medvedik, MMTP coordinators Steve Hill and Elena Milova, Lifespan.io President Keith Comito, and one of the most active contributors Alen Akhabaev. The event was one of the rewards from the MMTP campaign launched on Lifespan.io last year.

During the first section the panelists discuss the science and progress in the field, touching upon senescent cell therapy with senolytics, its progress and limitations, stem cells therapies and other promising interventions to slow down and potentially reverse age-related damage to health.

The second section moves to the discussion of the existing bottlenecks in advocacy, and what the members of the community can do to promote and popularize rejuvenation biotechnology among the general public more effectively.