A Perspective on how the tools of behavioral science and the emerging field of diverse intelligence help to understand decision-making of cellular collectives in evolutionary and biomedical contexts.
Congratulations to Yang (Claire) Zeng and her team for their work on DoriVac, a DNA origami vaccine which utilizes precisely spaced CpG oligonucleotides to enhance immunological responses against chosen antigens.
The spacing of ligands presented to cells can have a huge impact on cellular responses. DNA origami is used to block structures to control the distribution of Toll-like receptor ligands and optimize presentation in the activation of dendritic cells in cancer immunotherapy.
“In adults with diabetes alone—where poor blood flow can lead to quickly worsening wounds that are often very slow or impossible to heal—the lifetime risk of developing a diabetic foot ulcer (DFU), the most common diabetes-related wound, is 20–35 percent and this number is rising with increased longevity and medical complexity of people with diabetes,” stated lead author, Yen-Zhen Lu, PhD, an investigator at ARMI.
Nociceptors— neurons that sense pain, tissue damage, and inflammation, among other functions— respond to wounds by producing a neuropeptide called calcitonin gene-related peptide (CGRP). “Nociceptor endings grow into injured skin and muscle tissues and signal to immune cells through the neuropeptide CGRP during the healing process,” the authors wrote. Immune cell response in neutrophils, monocytes, and macrophages are modified to encourage active repair in the region.
Individuals with diseases like diabetes or elderly people have reduced production of CGRP, leading to poor, inefficient, or incomplete wound healing. The new study explores the impact of CGRP alone by introducing it into diabetic mice as well as mice without nociceptors. “Delivery of an engineered version of CGRP accelerated wound healing and promoted muscle regeneration,” the authors wrote. “Remarkably, this neuropeptide acts on immune cells to control them, facilitating tissue healing after injury,” added co-author Mikaël Martino, PhD, associate professor, ARMI.
Here’s a new Forbes review by world leading futurist Tracey Follows on the book: Transhuman Citizen:
What does Transhumanism, Ayn Rand and the U.S. Presidential election have in common? They are the connecting themes in a new book by Ben Murnane entitled, “Transhuman Citizen”
The book tells the story of Zoltan Istvan, a one-time U.S. Presidential candidate, who drove a coffin-shaped bus around the U.S. attempting to persuade the public that death is not inevitable and that transhumanism is a political as much as a scientific solution to the troubles of the 21st Century.
Continue reading “Can Transhumanism Rescue The West From The Threat Of AI?” »
A new study indicates a link between sleep apnea and increased memory or thinking problems, based on self-reported data from over 4,000 participants.
People who experience sleep apnea may be more likely to also have memory or thinking problems, according to a preliminary study that will be presented at the American Academy of Neurology’s 76th Annual Meeting taking place April 13–18, 2024, in person in Denver and online. The study shows a positive association but did not determine whether sleep apnea causes cognitive decline.
Sleep apnea is when people stop and restart breathing repeatedly during sleep which can lower oxygen levels in the blood. Symptoms include snorting, gasping, and breathing pauses. People with the disorder may also experience morning headaches or have trouble focusing on tasks.
Leafhoppers, a common backyard insect, secrete and coat themselves in tiny mysterious particles that could provide both the inspiration and the instructions for next-generation technology, according to a new study led by Penn State researchers. In a first, the team precisely replicated the complex geometry of these particles, called brochosomes, and elucidated a better understanding of how they absorb both visible and ultraviolet light.
This could allow the development of bioinspired optical materials with possible applications ranging from invisible cloaking devices to coatings to more efficiently harvest solar energy, said Tak-Sing Wong, professor of mechanical engineering and biomedical engineering. Wong led the study, which was published today (March 18) in the Proceedings of the National Academy of Sciences of the United States of America (PNAS).
Can anyone think of a good use for this protein in our cells in the future? Perhaps in space travel? 😁
Freeze ‘em, heat ‘em, blast them into empty space; with survival skills unlike any other organism on the planet, those hardy critters known as tardigrades will only come back for more.
While it’s clear their ability to withstand stress is in part due to their ability to turn their insides into gel, the mechanisms behind this act of metabolic preservation haven’t yet been made clear.
Continue reading “Scientists Put Tardigrade Proteins Into Human Cells. Here’s What Happened” »
An international research team led by RMIT University has designed and manufactured a virus-killing surface that could help control disease spread in hospitals, labs, and other high-risk environments. The surface made of silicon is covered in tiny nanospikes that skewer viruses on contact.
Lab tests with the hPIV-3 virus – which causes bronchitis, pneumonia, and croup – showed 96% of the viruses were either ripped apart or damaged to the point where they could no longer replicate to cause infection. These impressive results, featured on the cover of top nanoscience journal ACS Nano, show the material’s promise for helping control the transmission of potentially dangerous biological material in laboratories and healthcare environments.
