Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 2,724

Facebook’s chief AI scientist says that Silicon Valley needs to work more closely with academia to build the future of artificial intelligence

That’s what we are after, with AI. Understanding intelligence in machines, animals and humans, is one of the great scientific challenges of our times and building intelligent machines is one of the greatest technological challenges of our times. No single entity in industry, academia or public research has a monopoly on the good ideas that will achieve these goals. It’s going to take the combined effort of the entire research community to make progress in the science and technology of intelligence.

Facebook is taking an unusual recruitment model championed in law and medicine and applying it to artificial intelligence — and it’s working.

Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women

Evolutionary theory predicts that reproduction entails costs that detract from somatic maintenance, accelerating biological aging. Despite support from studies in human and non-human animals, mechanisms linking ‘costs of reproduction’ (CoR) to aging are poorly understood. Human pregnancy is characterized by major alterations in metabolic regulation, oxidative stress, and immune cell proliferation. We hypothesized that these adaptations could accelerate blood-derived cellular aging. To test this hypothesis, we examined gravidity in relation to telomere length (TL, n = 821) and DNA-methylation age (DNAmAge, n = 397) in a cohort of young (20–22 year-old) Filipino women. Age-corrected TL and accelerated DNAmAge both predict age-related morbidity and mortality, and provide markers of mitotic and non-mitotic cellular aging, respectively. Consistent with theoretical predictions, TL decreased (p = 0.031) and DNAmAge increased (p = 0.007) with gravidity, a relationship that was not contingent upon resource availability. Neither biomarker was associated with subsequent fertility (both p 0.3), broadly consistent with a causal effect of gravidity on cellular aging. Our findings provide evidence that reproduction in women carries costs in the form of accelerated aging through two independent cellular pathways.

Lighter, leaner, lifesaving: AF tests wearable medical tech

Wearable medical technology is designed to be small and lightweight to minimize additional burden on medical Airmen and the warfighter, whether they are on a remote battlefield or aboard an aircraft.

“Wearables provide greater accessibility,” said Dr. David Burch, a research biomedical engineer and the medical technology solutions team lead for the En Route Care Medical Technology Solutions Research Group, 711th HPW. “An aircraft has a very tight space and weight limit to maintain performance, and battlefield medics need to carry everything they use. Wearables provide accessibility to the human in a way that is better form, fit, and function.”

One wearable device that achieves that accessibility is a tissue oxygenation sensor, developed jointly with a private company. This small, soft, injectable sensor lets medics determine if a patient is able to be medically evacuated by assessing how well their blood transports oxygen to tissue.

Joris Column: Printcrime, augmenting humans, nanoconvergence and Segway polo

Often only a few years separate the tinfoil hats from the millionaires to be. I was writing the piece on the Youbionic arm and thinking of how we will use 3D printing to augment human beings. Clearly augmenting the human body with mechatronics would be a good idea. The flesh is weak but stepper motors are strong! Oh how we will eeck, ooow, brrrr whine in our old stepper augmented age. Machines could very well fill the gaps once our bodies start failing us. But, will old people homes really be filled with Borg grandmas?

Will your grandad get that night vision upgrade he’s always wanted so he can deer hunt whenever he damn pleases? Would it be a good idea if I on a whim replaced my tennis elbow with a tennis racket? We never get the future right and most of our visions of mechatronic augmentations of humans are either a bit Johhny Cab or they’re ruined by that tiara Geordi was wearing across his face in Star Trek. I know he can’t see it, but someone should have told him really.

Hallmarks of Aging: Cellular Senescence

This is part of our ongoing series of articles that discuss the Hallmarks of Aging. Published in 2013, the paper divides aging into distinct categories (“hallmarks”) of damage to explain how the aging process works and how it causes age-related diseases. Today, we will be looking at the hallmark of cellular senescence.

What are senescent cells?

As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby healthy cells to enter the same senescent state. Their presence causes many problems: they reduce tissue repair, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related diseases.

Building a better brain

Like a team in a science fiction movie, the six-lab squad funded by a 2017 MEDx Biomedical research grant is striking in its combination of diverse skills and duties.

The project is led by Kafui Dzirasa, MD’09, Ph.D.’07, HS’10-’16, associate professor of psychiatry and behavioral sciences and assistant professor in neurobiology and neurosurgery; and Nenad Bursac, Ph.D., professor of biomedical engineering and associate professor in medicine. Their team includes: Marc Caron, Ph.D., James B. Duke Professor of Cell Biology, professor in neurobiology and medicine; Fan Wang, Ph.D., professor of neurobiology; Christopher Kontos, MD, HS’93-’97, professor of medicine and associate professor of pharmacology and cancer biology—all at Duke University School of Medicine—and Jennie Leach, Ph.D., associate professor of chemical, biochemical, and environmental engineering at the University of Maryland Baltimore County, along with a cadre of committed graduate students, postdocs, and technicians.

Dzirasa’s background in engineering informs his approach to the study of neuropsychiatric illness and disease. In the summer of 2016, he and members of his lab were discussing the challenge of precisely monitoring .

The Rejuvenation Roundup

We have now launched the Rejuvenation Roundup Podcast, a monthly podcast accompanying our regular Rejuvenation Roundup digest. Check out the first episode of this new show hosted by Ryan O’Shea from Future Grind.

Brought to you by Nicola Bagalà, the Rejuvenation Roundup is our monthly digest, which takes a look at the big news stories involving the industry and helps keep you informed of current developments in the aging research field. Hosted by Ryan O’Shea of the Future Grind podcast, the Rejuvenation Roundup podcast is a regular podcast that complements the monthly written Roundup articles that we publish here on the blog. The podcast aims not to replace the regular written Roundup articles but to offer a deeper dive into some of the key stories, and it includes quotes and interviews from industry leaders. We suggest enjoying both written and podcast versions every month!

Ryan covers a variety of topics from a busy July in the rejuvenation biotechnology field, including the placement of “ageing-related” into the 11th revision of WHO’s International Classification of Diseases (ICD-11) along with insights from industry leaders about developing news in the field. You can find the accompanying July Rejuvenation Roundup article here, where Nicola brings you more industry news not covered in the podcast.

Deep Knowledge Analytics announces the publication of a new analytical report titled Longevity Industry in UK Landscape Overview

845 pages in length, the report aims to outline the history, present state and future of the Longevity Industry in the United Kingdom, profiling hundreds of companies, investors, and trends, and offering guidance on the most optimal ways in which UK longevity industry stakeholders, as well as government officials, can work to strengthen the industry, and allow it to reach its full potential as a global longevity science and preventive medicine hub. The report uses comprehensive infographics to distill the report’s data and conclusions into easily understandable portions, and interested readers can get a quick understanding of the report’s main findings and conclusions in its 10-page executive summary.

This special regional case study follows-up on the content and general outline of the Longevity Industry made by our consortium in the previous Longevity Industry Landscape Overviews, including Volume I “The Science of Longevity” (750 pages), and Volume II “The Business of Longevity” (650 pages), published earlier this year.

These ongoing analytical reports are part of a collaborative project by The Global Longevity Consortium, consisting of the Biogerontology Research Foundation, Deep Knowledge Analytics, Aging Analytics Agency and the Longevity. International platform.

/* */