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Category: biotech/medical – Page 258

Immunotherapy can boost the survival of early-stage lung cancer patients eligible for surgery when it’s combined with chemotherapy, a new clinical trial reports.

Those who got immunotherapy before and after surgery — along with pre-surgical chemo — had a 42% lower risk of cancer progression, recurrence or death than those who only received chemo, according to findings published Wednesday in the New England Journal of Medicine.

Further, about 25% of those who got immunotherapy and chemo had no cancer at all remaining after their surgery, compared with about 5% of those who got chemo alone.

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In episode 267 of the Stem Cell Podcast, we chat with Dr. Shankar Srinivas, a Professor of Developmental Biology in the Department of Physiology Anatomy and Genetics based in the Institute for Developmental and Regenerative Medicine at the University of Oxford. He is also a Zeitlyn Fellow and Tutor in Medicine at Jesus College. Using mouse and human embryos as model systems, his group looks at the control of patterning and morphogenesis during the establishment of the anterior-posterior axis, gastrulation, and early cardiogenesis. He discusses how tissues respond to forces during early development, characterizing cardiac progenitors, and training internationally.

Roundup Papers:
2:26 https://bit.ly/3yeD3ms.
7:14 https://bit.ly/4dKJ7nd.
19:06 https://go.nature.com/3V2SNSo.
27:10 https://go.nature.com/4dnC43H

38:40 Guest Interview.

#Cardiogenesis #DevelopmentalBiology.

Continue reading “The Stem Cell Podcast” | >

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein. Because the vehicle binds to a well-studied protein in the blood-brain barrier, the scientists say it has a good chance of working in patients.

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Everything in the universe may be preordained, according to physics.

By Dan Falk

On the morning of June 28, 1914, a Bosnian Serb student named Gavrilo Princip stood outside Moritz Schiller’s delicatessen near the Latin Bridge in Sarajevo. Sometime after 10:45 A.M., a motorcade carrying archduke Franz Ferdinand, heir to the throne of Austria-Hungary, passed within meters of Princip, who drew his 0.38-caliber pistol and fired. One bullet struck the archduke in the neck. He was rushed to the military governor’s residence for medical treatment, but by 11:30 A.M. he was pronounced dead.

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Building a useful quantum computer in practice is incredibly challenging. Significant improvements are needed in the scale, fidelity, speed, reliability, and programmability of quantum computers to fully realize their benefits. Powerful tools are needed to help with the many complex physics and engineering challenges that stand in the way of useful quantum computing.

AI is fundamentally transforming the landscape of technology, reshaping industries, and altering how we interact with the digital world. The ability to take data and generate intelligence paves the way for groundbreaking solutions to some of the most challenging problems facing society today. From personalized medicine to autonomous vehicles, AI is at the forefront of a technological revolution that promises to redefine the future, including many challenging problems standing in the way of useful quantum computing.

Quantum computers will integrate with conventional supercomputers and accelerate key parts of challenging problems relevant to government, academia, and industry. This relationship is described in An Introduction to Quantum Accelerated Supercomputing. The advantages of integrating quantum computers with supercomputers are reciprocal, and this tight integration will also enable AI to help solve the most important challenges standing in the way of useful quantum computing.

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UCLA Health researchers have identified a process that memories while reducing metabolic costs, even during sleep. This efficient memory is found in a brain region essential for learning and memory, which is also where Alzheimer’s disease originates.

The discovery is published in the journal Nature Communications.

Does this sound familiar: You go to the kitchen to fetch something, but when you get there, you forget what you wanted. This is your working memory failing. Working memory is defined as remembering some information for a short period while you go about doing other things. We use working memory virtually all the time. Alzheimer’s and dementia patients have working memory deficits and it also shows up in mild cognitive impairment (MCI). Hence, considerable effort has been devoted to understanding the mechanisms by which the vast networks of neurons in the brain create working memory.

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