Lifeboat Foundation

Biological computing machines, such as micro and nano-implants that can collect important information inside the human body, are transforming medicine. Yet, networking them for communication has proven challenging. Now, a global team, including EPFL researchers, has developed a protocol that enables a molecular network with multiple transmitters.

First, there was the Internet of Things (IoT) and now, at the interface of computer science and biology, the Internet of Bio-Nano Things (IoBNT) promises to revolutionize medicine and health care. The IoBNT refers to biosensors that collect and process data, nano-scale Labs-on-a-Chip that run medical tests inside the body, the use of bacteria to design biological nano-machines that can detect pathogens, and nano-robots that swim through the bloodstream to perform targeted drug delivery and treatment.

“Overall, this is a very, very exciting research field,” explained Assistant Professor Haitham Al Hassanieh, head of the Laboratory of Sensing and Networking Systems in EPFL’s School of Computer and Communication Sciences (IC). “With advances in bio-engineering, synthetic biology, and nanotechnology, the idea is that nano-biosensors will revolutionize medicine because they can reach places and do things that current devices or larger implants can’t,” he continued.

The COVID-19 pandemic supply shortfalls and geopolitical issues cast a bright light on the decline of semiconductor manufacturing in the United States, down from 37 percent of the global total in 1993 to about 12 percent now. The Creating Helpful Incentives to Produce Semiconductors and Science Act of 2022 (CHIPS Act) directed $280 billion in spending, with the bulk on scientific research and development.

America needs better computer chips.

Mobile devices are ubiquitous; we carry them around in a pocket or purse and use them for everyday tasks. However, they are connected to centralized servers and thus cannot learn much about or adjust to their complicated and changing environments independently.

They are faster than ambulances in situations where timing is key.

Karolinska Institutet researchers have been investigating the idea of sending drones equipped with automated external defibrillators (AEDs) to patients in cardiac arrest instead of ambulances and have now found that, in more than half of the cases, the drones were three minutes ahead of the vehicles. In addition, in the majority of cases where the patient was in cardiac arrest, the drone-delivered defibrillator was employed to stop the condition from getting worse or leading to death.

The most simple factor

Continue reading “Drones with defibrillators are saving people from cardiac arrest” »

The engineers at Fourier Intelligence have successfully combined functionality with a touch of creativity, making the GR-1 more than just a caregiver. The 300-Nm hip actuators, equivalent to 221 pound-feet (lb-ft), empower the GR-1 to lift a remarkable 110 lb (50 kilograms, kg) – an impressive feat for a robot of its stature. This capability positions the GR-1 as valuable in assisting patients with various activities, from getting up from a bed or toilet to navigating a wheelchair.

Pierre Agostini, Ferenc Krausz and Anne L’Huillier share the 2023 Nobel Prize in Physics for experiments that “have given humanity new tools for exploring the world of electrons inside atoms and molecules.” A more succinct description is that they have given us attosecond physics.

Attosecond physics is the science of the exceedingly, extremely, exceptionally [insert your own hyperbolic adverb here] fast. To put it into context, L’Huillier’s first call from the Nobel Prize’s Adam Smith after she received the news took 3 minutes 48 seconds, or-1 attoseconds. Her first heartbeat during that call lasted a second, or a billion billion attoseconds. Almost defying a description, an attosecond is an unfathomably tiny amount of time. But it happens to be the natural timescale of the near-instantaneous dance of electrons.

Continue reading “Nobel Prize in Phyiscs 2023” »

In particular I like the 3D modeling segment.

Here Dr Seranova talks about stem cell use in helping with research into diseases of aging, particularly generating organiods of the brain by growing them from stem cells.
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Continue reading “The Promise Of Stem Cells In Aging Research | Dr Elena Seranova Interview Series Ep3” »

Refractory organic pollutants, including phenols, perfluorinated compounds, and antibiotics, are abundant in various industrial wastewater streams such as chemical, pharmaceutical, coking, and dyeing sectors, as well as municipal and domestic sources. These pollutants pose significant threats to ecological well-being and human health.

The imperative to achieve complete removal of organic contaminants from water and facilitate water recycling is paramount for enhancing environmental quality and ensuring sustainable economic and social progress. Addressing the efficient removal of recalcitrant organic pollutants in water is not only a focal point in environmental chemical pollution control research but also a pivotal technical challenge constraining industrial wastewater reuse.

Advanced oxidation processes (AOPs), especially heterogeneous AOPs, yield strongly reactive oxygen species including ·OH, ·O₂^-, and ·SO₄^- to oxidize organic pollutants under ambient conditions, are appealing wastewater treatment technologies for decentralized systems. AOPs often need excessive energy input (UV light or electricity) to activate soluble oxidants (H₂O₂, O₃, persulfates), thus more cost-effective AOPs are urgently required.

Macrophages, small but essential cells in the immune system, hold promise for cell-based therapies in numerous health conditions. Unlocking the full potential of macrophage therapies depends on our ability to observe their activities within the body. Now, researchers from Penn State have potentially developed a method to monitor these cells in action.

In a study published in the journal Small, the Penn State researchers report a novel ultrasound imaging technique to view macrophages continuously in mammal tissue, with potential for human application in the future.

“A macrophage is a type of immune cell that is important in nearly every function of the immune system, from detecting and clearing pathogens to wound healing,” said corresponding author Scott Medina, the William and Wendy Korb Early Career Associate Professor of Biomedical Engineering. “It is a component of the immune system that really bridges the two types of immunity: innate immunity, which responds to things very quickly but in a not very precise way, and adaptive immunity, which is much slower to come online but responds in a much more precise way.”

For decades, researchers have sought ways to precisely manipulate and identify individual molecules like DNA in liquid environments. Such capabilities could revolutionize areas ranging from disease diagnosis to drug development. However, the randomness of molecular movements in fluids has hindered progress.

Now, scientists from Shenzhen University and the Chinese University of Hong Kong report promising advances in optical tweezing techniques that allow exquisite control over nanoscale biological particles (Light: Science & Applications, “CRISPR-powered optothermal nanotweezers: Diverse bio-nanoparticle manipulation and single nucleotide identification”).

A The diagrammatic sketch of the three components in the solution: DNA@AuNS conjugate, CRISPR/Cas12a complex, and target ssDNA. b Optical setup, the BS, SPF, and TL are beam splitter, short pass filter, and tube lens (f = 200 mm), respectively. Additional details of the setup are provided in the Materials and Methods section. c Dispersion of the three components in the solution without optical heating. d Optothermal net force induced migration and DNA@AuNS conjugate cleavage upon optical heating, the heating laser power is 0.5 mW. e Observation of the cleavage after the optical heating is switched off. (© Light: Science & Applications) (click on image to enlarge)