New study from Wenxing Qin, Yuran Duan, Zhiqiang Hu, Yueru Hou, Daqian Xu and colleagues (Zhejiang University School of Medicine) unveils a novel mechanism by which the metabolic enzyme PCK1 hinders cGAS-STING activation by competitively consuming GTP, consequently fostering tumor immune evasion.

This study unveils a novel mechanism by which the metabolic enzyme PCK1 hinders cGAS-STING activation by competitively consuming GTP, consequently fosterin.