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Turning Back the Clock on Aging Cells

Researchers at Stanford University report that they can rejuvenate human cells by reprogramming them back to a youthful state. They hope that the technique will help in the treatment of diseases, such as osteoarthritis and muscle wasting, that are caused by the aging of tissue cells.

A major cause of aging is thought to be the errors that accumulate in the epigenome, the system of proteins that packages the DNA and controls access to its genes. The Stanford team, led by Tapash Jay Sarkar, Dr. Thomas A. Rando and Vittorio Sebastiano, say their method, designed to reverse these errors and walk back the cells to their youthful state, does indeed restore the cells’ vigor and eliminate signs of aging.

In their report, published on Tuesday in Nature Communications, they described their technique as “a significant step toward the goal of reversing cellular aging” and could produce therapies “for aging and aging-related diseases.”

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

SARS-CoV-2 uses the SARS-CoV receptor ACE2 for host cell entry.

The spike protein of SARS-CoV-2 is primed by TMPRSS2.

Antibodies against SARS-CoV spike may offer some protection against SARS-CoV-2.


The emerging SARS-coronavirus 2 (SARS-CoV-2) threatens public health. Hoffmann and coworkers show that SARS-CoV-2 infection depends on the host cell factors ACE2 and TMPRSS2 and can be blocked by a clinically proven protease inhibitor. These findings might help to establish options for prevention and treatment.

Frequently Asked Questions About Novel Coronavirus (COVID-19)

1. Why Amazon will last longer than most businesses during the Covid-19 epidemic.

2. The challenges Amazon must overcome during the Covid-19 epidemic.

3. Ideas as to how they can overcome the challenge Amazon faces.


Coronaviruses are a large group of viruses that cause diseases in animals and humans. They often circulate among animals and can sometimes evolve and infect people. In humans, the viruses can cause mild respiratory infections, like the common cold, but can lead to serious illnesses, like pneumonia.

The 2019 novel coronavirus (COVID-19, previously known as 2019-nCoV) emerged in a seafood and poultry market in Wuhan, China in December 2019. It likely spread from an unknown animal to humans. Human-to-human transmission occurs through close contact.

Information about the novel coronavirus is changing rapidly.

$20 trillion lawsuit against China! US group says coronavirus is bioweapon

The plaintiffs have sought $20 trillion, which is a bigger amount than China’s GDP, claiming coronavirus is the result of a biological weapon prepared by the Chinese authorities.

They have accused China of aiding and abetting death, provision of material support to terrorists, conspiracy to cause injury and death of US citizens, negligence, wrongful death, and assault and battery.

Also read: Coronavirus impact: India to produce hazmat suits locally as global suppliers say no.

A CRISPR-based Cure for Arthritis

Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions. Such stem cells, known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy), develop into cartilage cells that produce a biologic anti-inflammatory drug that, ideally, will replace arthritic cartilage and simultaneously protect joints and other tissues from damage that occurs with chronic inflammation.

A Letter About Coronavirus, the Longevity Movement, & Why Quarantining is Killing Us

I have not been a supporter of an extended public quarantine or shut down, if any. There are a number of reasons why (governments steal liberty during such times; national debt increases and is used to the point of total socialism; inequality becomes permanent; etc), but in this letter below to everyone I want to talk specifically about why a quarantine is ultimately harming the life extension and #transhumanism movements. Don’t ever forget, we are in a race to save the lives of “everyone” right now with the plague of aging, not just those who might get #coronavirus.


Dear Fellow Humans.

If you believe in the life extension movement of trying to live indefinitely through science and technology, then you likely should not support the worldwide quarantine (at least don’t support it over 14 days in the West where we don’t have the ability to do it as efficiently as Asia). It’s horrible that so many lives will be lost by COVID-19, but in a worse-case scenario it’s likely 100 million people will die globally (mostly older people who have only a few years left to live due to their underlying medical conditions of aging — and who have likely been kept alive due to science and 21st Century medicine anyway). But the damage we could cause (and almost certainly are causing) with the quarantine and shut down to the US and global economy may cost the life extension movement and its scientific research possibly three to five years of progress — because the funding, projects, and jobs around the anti-aging industry will disappear for a notable time. The math shows that if we achieve indefinite lifespans for the human race by the year 2035 vs 2040, approximately 250 million lives will be spared and could then go on indefinitely. The aging math (or life hours) for any transhumanist shows that if we care about human life and longevity — about how long people alive today live — then we should not quarantine the world right now, but get the economy going again as a first priority so that we may fund the future of anti-aging science for the species. Some of us call this reasoning the Transhumanist Wager. For the sake of everyone alive today, it must be acknowledged that there is a dramatically larger percent gain (many thousands of percent) of overall life years for our species by not quarantining and shutting down the world. This is all a horrible scenario, and one I am terribly sad to share with you, but that doesn’t mean we should cower from facts. We owe our species the most courageous decision for its long-term longevity of all its living citizens.

Live long and prosper, Zoltan Istvan

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