Lifeboat Foundation

Aubrey de Grey has set himself a simple task. The 54-year-old cofounder of the SENS Research Foundation wants to end biological aging for good. So sure is he of his mission, he proclaims the first human being to live to the age of 1,000 has already been born. De Grey believes that, within the next 20 years or so, scientists will finally solve one of humanity’s greatest problems.

“The fact is, aging kills 110,000 people worldwide every fucking day,” de Grey said at a Virtual Futures event attended by Inverse in London on Wednesday, in a conversation with group director Luke Robert Mason. “It doesn’t just kill them. You have to take into account all the suffering that comes before.”

Through his foundation, de Grey is working to solve seven types of aging damage that he believes are the key to a breakthrough. These are tissue atrophy, cancerous cells, mitochondrial mutations, death -resistant cells, extracellular matrix stiffening, extracellular aggregates, and intracellular aggregates. It may sound like a complex salad of jargon, but de Grey claims that because science has an understanding of how to fix all these damages, aging can end for good.

Continue reading “Why This Aging Expert Thinks First 1,000-Year-Old Person is Already Alive” »

Other uses include biosensors and wound patches.

[scroll down to view the video.] The animation house of Kurzsegat provides us with an 8-minute video on how the microbiome influences our health and mood and even encourages us to eat junk food. Scientists have linked the human microbiome to a variety of health conditions such as cancer, autism, weight gain, Parkinson’s Disease and even our mental health.

Last week, Chancellor Philip Hammond announced in the Autumn Budget a £500m package of investment into tech initiatives, including the development of artificial intelligence.

Which must have had the Channel 4 executives ordering trebles all round, because with perfect timing they’ve designated this week the “Rise of the Robots season”, with a schedule that includes documentaries on the take-off of artificial intelligences (AIs) as consulting doctors, a David Tennant -narrated piece on the challenge of making robots as human as possible, and the one that’s had the tabloids hot under the collar, today’s The Sex Robots Are Coming – which needs little further explanation.

Doctor Who and the Invasion of the Sex-Bots aside, though, is it actually possible that the dream of science fiction writers going back a century or more is on the verge of reality? Are we really about to live in the long-promised future of robots and AIs?

Continue reading “The robots are coming – but will they really take all our jobs?” »

Summary: Novel resveratrol analogs rejuvenate aging human cells, lengthening their Full Explanation of Telomeres.

Telomeres are a unique segment of DNA that sits at the end of the chromosome. Telomeres have repetitive sequences that are recognized as the end of the chromosome but are only there to keep the chromosome from becoming frazzled or damaged. Moreover, every time the cell divides, the telomeres also divide. But sometimes the telomeres can become shorter. As they grow shorter, they act like a clock that lets the cell know how old it is. The length of the telomere is the molecular clock, predicted by Hayflick. The telomere mechanism limits the number of times a cell can divide without losing DNA. When telomeres become too short, the cells cease multiplying and either become senescent or die.

Moreover, one of the interesting features about telomeres is that in cancer cells stay immortal by keeping their telomeres long. That means that cancer cells can continue dividing, long after they should have reached the end of their lifespan. This is one of the tactics that cancer cells use to trick the body into letting them keep replicating. [Source – NHGRI and Wikipedia.].

Continue reading “Old Human Cells Rejuvenated with ‘Breakthrough’ Anti-Aging Discovery” »

When taken daily, rapamycin causes side effects, the most serious of which include an increased risk of infection due to immune suppression, elevated blood sugar, and an increased risk of type 2 diabetes. Some of the side effects of daily rapamycin therapy are extremely serious, occasionally causing death due to infections. The complete list of side effects reported by daily rapamycin users includes high cholesterol, high triglycerides, glucose intolerance, insulin resistance, new-onset diabetes, anemia, thrombocytopenia, gastrointestinal disorders, sinusitis, respiratory and urinary infections, testicular dysfunction, and skin problems.

Daily vs. Intermittent Rapamycin Therapy

Rapamycin therapy is promising. However, researchers still need to determine the dosage that provides health benefits while eliminating harmful side effects. Scientists think they have already found the answer because rapamycin behaves differently when taken daily, as opposed to intermittently.

Continue reading “Can a Revolutionary Rapamycin Therapy Slow Down Aging in Our Bodies?” »

Summary: (Video) A short animation from the journal Nature demonstrates revolutionary new additions to the CRISPR toolbox some call CRISPR 2.0. Scroll down for video. [This article first appeared on LongevityFacts. Follow us on Reddit | Google+ | Facebook. Author: Brady Hartman.]

Techniques to modify DNA in the genome have existed for several decades, and the original CRISPR-Cas9, called CRISPR 1.0, brought an era of faster, cheaper, and more efficient gene editing tools. A short video from the journal Nature shows you how scientists have revolutionized the original CRISPR-Cas9 system, significantly expanded its toolbox, creating a more powerful set of tools some call CRISPR 2.0. Genetic engineers have discovered how to make CRISPR perform new tricks such as improved gene editing, turning genes on and off, and making genes glow for research.

What are gene editing and crispr-cas9?

Continue reading “CRISPR 2.0: New Ways to Edit Genes in Our Body (video)” »

Summary: Will gene drive wipe out malaria-causing mosquitoes, or will the genetic technology that ‘spreads like wildfire’ cause a catastrophe? Gene drive raises hopes and fears as a team of scientists funded by the Bill & Melinda Gates Foundation are using it to wipe out the mosquitoes that carry malaria, to eradicate the disease. [This article first appeared on LongevityFacts. Follow us on Reddit | Google+ | Facebook. Author: Brady Hartman.]

In a basement lab at the Imperial College London (ICL), a group of researchers led by Andrew Hammond are on a mission to wipe out malaria. The scientists are funded by the Bill & Melinda Gates Foundation and are using a technology called gene drive – a souped-up form of genetic engineering designed to wipe out the mosquitoes that carry the disease.

The lab contains cages of mosquitoes modified with the gene drive, along with an additional gene that makes their eyes and other body parts glow red under laser light.

Continue reading “Microsoft’s Gates to Genetically Engineer Laser Lit Mosquitoes Using Gene Drive” »

Summary: Can a gene fuel obesity? Variants of a gene called ‘ankyrin-B’ – a gene carried by millions of Americans – could cause individuals to put on pounds through no fault of their own. [This article first appeared on LongevityFacts. Follow us on Reddit | Google+ | Facebook. Author: Brady Hartman]

We often attribute obesity to eating too much and exercising too little. However, the evidence is growing that at least some of our weight gain is predetermined by our genes. And if a simple genetic variant causes weight gain, then it’s a prime target for gene editing.

New research from the University of North Carolina suggests that variants in a gene called ankyrin-B, a gene carried by millions of Americans, could cause individuals to gain weight through no fault of their own.