Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 2252

As I look back on the year, I am also thinking about the specific areas I work on. Some of this is done through our foundation but a lot of it (such as my work on energy and Alzheimer’s work) is not. What connects it all is my belief that innovation can save lives and improve everyone’s well-being. A lot of people underestimate just how much innovation will make life better.

Here are a few updates on what’s going well and what isn’t with innovation in some areas where I work.

Bill Gates looks back on 2018, and shares a few thoughts on what’s going well and what isn’t with innovation in some specific areas that he works on.

Read more

A machine which triples the time livers can survive outside the body promises to halve the transplant waiting list, experts have said as officials approved its use in the NHS.

Hundreds more patients with advanced liver disease — Britain’s fifth biggest killer — have hope of a successful transplant after the “game-changing” technique was given the green light by the National Institute of Health and Care Excellence (Nice).

Currently livers intended for transplant typically survive for only about eight to ten hours on ice.

Read more

New research published in the journal Nature Medicine has described the results of a five-year study into the association between a breakdown of the blood-brain barrier and the onset of cognitive impairment. The study suggests leaky capillaries in the brain can act as an early biomarker of cognitive decline, and a new drug being developed for stroke patients may be an effective treatment.

Read more

In the study, researchers focused on a mechanism that routinely serves the cell by marking human virus-like genes in order to avoid identifying them as viruses. Together with the Harvard team, Levanon has discovered that “when inhibiting this mechanism, the immune system can be harnessed to fight cancer cells in a particularly efficient manner, and most effectively in lung cancer and melanoma.”

“We found that if the mechanism is blocked, the immune system is much more sensitive,” Levanon said. “When the mechanism is deactivated, the immune system becomes much more aggressive against the tumor cells.”

According to researchers, most patients with cancer either do not respond to immune checkpoint blockade (a type of drug that blocks certain proteins made by some types of immune system cells, such as T cells, and some cancer cells) or develop resistance to it. The National Cancer Institute (NCI) says these proteins help keep immune responses in check and can keep T cells from killing cancer cells. “When these proteins are blocked, the ‘brakes’ on the immune system are released and T cells are able to kill cancer cells better,” says the NCI. Some immune checkpoint inhibitors are used to treat cancer as immunotherapy uses the body’s immune system to fight cancer.

Read more

The past of our ancestors lives on through us: Groundbreaking research illustrates how parental experience is not only epigenetically imprinted onto offspring, but onto an unprecedented number of future generations. Rather than occurring over the elongated time scale of millions of years, genetic change can transpire in real biological time through nanoparticles known as exosomes…

Until recently, it was believed that our genes dictate our destiny. That we are slated for the diseases that will ultimately beset us based upon the pre-wired indecipherable code written in stone in our genetic material. The burgeoning field of epigenetics, however, is overturning these tenets, and ushering in a school of thought where nurture, not nature, is seen to be the predominant influence when it comes to genetic expression and our freedom from or affliction by chronic disease.

Epigenetics: the demise of biological determinism.

Read more

For a nation that spends more on healthcare per citizen than almost any other, America isn’t exactly reaping the rewards. Life expectancy has been steadily climbing for decades now, but in the last few years it’s taken a troubling turn in the other direction.

A new report from the Centers for Disease Control shows that a small decrease in life expectancy, from 78.7 to 78.6 years, is part of a continuing trend. Even as we make progress treating cancer, heart disease, and stroke—three of the biggest killers—we’re losing ground on other fronts and have been since 2014. That makes this continuous decline unlike anything we’ve seen since World War I and the Spanish influenza, which both happened between 1915 and 1918.

In its report, the CDC highlighted three things that have contributed to American’s shrinking life expectancy in recent years: drug overdoses, chronic liver disease, and suicide. “Increased death rates for unintentional drug overdoses in particular—a subset of unintentional injuries—contributed to the negative change in life expectancy observed in recent years,” the report reads.

Read more

This is incredible!

Researchers have been able to coax human breast cancer cells to turn into fat cells in a new proof-of-concept study in mice.

To achieve this feat, the team exploited a weird pathway that metastasising cancer cells have; their results are just a first step, but it’s a truly promising approach.

When you cut your finger, or when a foetus grows organs, the epithelium cells begin to look less like themselves, and more ‘fluid’ – changing into a type of stem cell called a mesenchyme and then reforming into whatever cells the body needs.

Continue reading “Researchers Successfully Turn Breast Cancer Cells Into Fat to Stop Them From Spreading” | >