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Researchers at Duke-NUS Medical School, Singapore, have developed an approach to regenerate heart muscle using stem cells. Their method for priming stem cells to become heart tissues could potentially enable heart regeneration stem cell therapies, according to their study published in the journal Cell Reports.

The self-regeneration of human following injury is extremely limited. Scientists have been studying techniques to prompt different kinds of stem to differentiate into cell precursors, which could then help rebuild heart muscle fibres. However, their approaches have not yet met regulations set forth by the US Food and Drug Administration and the European Medicines Agency for regenerative therapies.

Dr. Lynn Yap, a Senior Research Fellow at Duke-NUS’ Cardiovascular and Metabolic Disorders (CVMD) Programme and the study’s first author, explained, “Regulatory authorities specifically require these stem-cell-derived precursors be prepared from human-only cells and in cultures that use clearly defined chemicals and no animal components. The method must be reproducible, and the cells must have clear characteristics while not leading to adverse side effects when injected.”

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The presence of senescent cells has been implicated in a wide range of age-related diseases and even conditions such as T1 diabetes. Today, we want to draw your attention to a new publication that explores the relationship between senescent cells and intervertebral disc degeneration (IDD).

It was already known that senescent cells increase during the progression of IDD, but it was not known if they were a driver or a consequence of IDD.

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Today’s efforts in AI are somewhat less flashy, though still potentially revolutionary, and all seem to recognize one vital lesson: treating patients is both art and science. Rather than attempting to replace the physicians in medical practice, AI can, and should, say more experts, become a valuable tool in enhancing what doctors do.


Here’s where AI in medicine excels — and where it doesn’t yet measure up.

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During the Great Embryonic Stem Cell Debate, circa 2001–2008, I watched “the scientists” blatantly lie about the supposedly low potential for adult stem cells and the CURES! CURES! CURES that were just around the corner from embryonic stem cells. You remember: Children would soon be out of their wheelchairs and Uncle Ernie’s Parkinson’s would soon be a disease of the past.

The pro-ESCR campaign was filled with so much disinformation and hype — willingly swallowed by an in-the-tank media — all in a corrupt attempt to overturn the minor federal funding restrictions over ESCR imposed by the president, and to hurt President Bush politically.

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Revolutions is a series that brings together a hand-picked selection of recent articles canvassing cutting-edge insights into major scientific advances. This installment brings you up to date with the ground-breaking new discoveries made around the regenerative possibilities of induced pluripotent stem cells, which can theoretically be coaxed into any kind of cell in the human body.

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