Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,230

To kill bacteria in the blood, our immune system relies on nanomachines that can open deadly holes in their targets. UCL scientists have now filmed these nanomachines in action, discovering a key bottleneck in the process which helps to protect our own cells.

The research, published in Nature Communications, provides us with a better understanding of how the kills bacteria and why our own cells remain intact. This may guide the development of new therapies that harness the immune system against bacterial infections, and strategies that repurpose the immune system to act against other rogue cells in the body.

In earlier research, the scientists imaged the hallmarks of attack in live bacteria, showing that the immune system response results in ‘bullet holes’ spread across the cell envelopes of bacteria. The holes are incredibly small with a diameter of just 10 nanometres.

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“One of the biggest roadblocks to generating functional tissue replacements has been our inability to print the complex vasculature that can supply nutrients to densely populated tissues,” said Jordan Miller, assistant professor at Rice University in the US.

“Further, our organs actually contain independent vascular networks — like the airways and blood vessels of the lung or the bile ducts and blood vessels in the liver,” Miller said.

“These interpenetrating networks are physically and biochemically entangled, and the architecture itself is intimately related to tissue function. Ours is the first bioprinting technology that addresses the challenge of multi vascularisation in a direct and comprehensive way,” he said.

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For most patients, a diagnosis of stage 4 non-small cell lung cancer comes with a dire prognosis. But for patients with specific mutations that cause the disease, there are potentially life-saving therapies.

The problem is that these mutations, known as ALK and EGFR, are not always identified in patients — meaning they never get the treatment.

A new study from the Fred Hutchinson Cancer Research Center in Seattle used machine learning to find these needle-in-a-haystack patients. The idea was to leverage cancer databases to see if patients were being tested for the mutations and receiving these personalized treatments.

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AM I Wrong for wondering about Metformin and its true benefits against the Senesonic-Sensonic pandemic Plague mankind has called aging??? Metformin has been in use truly since the 1920’s and we have not found today an elderly person who is living 125 or 150 years who states they merely took metformin for diabetes??? Now Met has proven itself as a resistant against diabetes due to preventing the liver from making to much glucose that then enters the body. But is it a Longevity drug for mankind is the burning question??? You be the Judge… {I found this link on Antonei Benjamin Csoka group page on the book of faces} Respect r.p.berry & AEWR wherein we have found the causes and a cure for the Pandemic plague mankind has called aging… https://we search for partners and investors to join us in agings end…

Does it make sense to treat ageing as a disease?


Stem cell transplants have been of great interest to aging researchers, and, in a new study, they have successfully increased mouse lifespan by using stem cell therapy. While this has been previously achieved, this experiment was more refined than older studies and sheds new light on the potential of tissue regeneration through stem cells.

The significant extension of maximum lifespan could be considered an indication that any intervention is targeting a core hallmark of aging or, in the case of small increases of lifespan, at least indirectly influencing it.

Through bone marrow transplants, the researchers have significantly increased the lifespans of mice and believe that they are directly targeting an aging process directly [1]. Given that stem cell exhaustion is a hallmark of aging, they are likely correct.

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Neuroscience, computer vision collaborate to better understand visual information processing PITTSBURGH—Neuroscientists and computer vision scientists say a new dataset of unprecedented size — comprising brain scans of four volunteers who each viewed 5,000 images — will help researchers better understand how the brain processes images. Researchers at Carnegie Mellon University and Fordham University, reporting today in the journal Scientific Data, said acquiring functional magnetic resonance imaging (fMRI) scans at this scale presented unique challenges. Each volunteer participated in 20 or more hours of MRI scanning, challenging both their perseverance and the experimenters’ ability to coordinate across scanning sessions. The extreme.


Spaceflight — in addition to being awesome — causes significant changes in the human immune system. We are careful with our astronauts so they don’t get sick during spaceflight, but we need to ensure their immune systems are strong when they start embarking on longer trips. Learn about the latest International Space Station research: https://www.nasa.gov/mission_pages/station/research/news/rr-…y-in-space

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