Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 2,228

If the virus that causes flu were an ice cream cone, then the yearly vaccine teaches the immune system to recognize just the scoop – chocolate one year, strawberry the next. As the virus changes each year, so too must the vaccine.

A new approach that teaches the body to recognize the cone portion of the – which stays the same year-to-year – could shake up that yearly vaccination ritual and protect people against pandemic flu like the one that killed 40 to 50 million people in 1918. The team working on this new approach, led by Stanford biochemist Peter Kim, has shown early signs that their technique works in . They warn that they still need to make their more specific and show it works in much larger studies before testing it in people.

“We think it could be very generalizable,” said Kim, who is the Virginia and D.K. Ludwig professor of biochemistry and the lead investigator of the infectious disease initiative at the Chan Zuckerberg Biohub. “It could be important for coming up with a universal that would protect against pandemic flu, as well as for HIV.”

Read more

A drug commonly used to treat multiple sclerosis may, after necessary modifications, one day be used to treat patients with epilepsy, researchers in Prof. Inna Slutsky’s lab at the Sackler Faculty of Medicine and Sagol School of Neuroscience at Tel Aviv University have discovered.

This is good news for patients with Dravet syndrome, one of the most dangerous forms of childhood epilepsy, for which there is currently no .

According to a new study published on April 29 in Neuron, Tel Aviv University researchers uncovered a piece of a puzzle that has eluded scientists for 100 years of studying homeostasis: What is the mechanism that maintains activity set points in ?

Read more

The recent clinical trial was only conducted on patients with lymphoma, but the researchers suggested their approach could be potentially used to treat other types of cancer — and that it could improve the efficacy of other immunotherapies, including checkpoint blockade.

“The in situ vaccine approach has broad implications for multiple types of cancer,” said Brody, the study’s lead author and the director of the Lymphoma Immunotherapy Program at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. “This method could also increase the success of other immunotherapies such as checkpoint blockade.”

Related Articles Around the Web.

Read more

MeiraGTx’s founders were interested in those uses; the biotech’s programs today are in diseases of the eye, salivary gland and brain.

But “we wanted to have a broader perspective on how you could potentially use gene therapy” too, CEO Alexandria Forbes says.

That vision is a high-tech, futuristic one, in which the human body can essentially become a medicine-making factory, enabled by gene therapy. But it’ll require more research, and is still years from fruition.

Read more

“Smart” contact lenses sound like something from a sci fi movie — but they’re real, and they could help troops in the field.

French engineering school IMT Atlantique revealed what it calls “the first stand-alone contact lens with a flexible micro battery” earlier this month.

And, notably, it caught the attention of the U.S. military’s attention: the Defense Advanced Research Projects Agency (DARPA) is reportedly interested in the contact lens to augment troops’ visual capabilities in the field, according to Task and Purpose — meaning the gadget could represent the augmented contact lens that DARPA has spent a decade searching for.

Weird Flex

Continue reading “DARPA: This Smart Contact Lens Could Give Soldiers Superpowers” | >

Jose Cordeiro is promoting the development of rejuvenation biotechnologies in Spain and the integration of Latin American immigrants into Spain’s aging society to maintain the country’s productivity. He was at the recent Undoing aging conference in Berlin and gave us an interview about his political goals.

At Undoing Aging 2019, jointly organized by SENS Research Foundation and Forever Healthy Foundation, there was a session focused on the ways to make healthy life extension and medical progress a greater part of the global agenda. Among the speakers there was Jose Cordeiro, the vice chair of Humanity Plus, director of The Millennium Project, fellow of the World Academy of Art and Science, and board member of the Lifeboat Foundation.

Jose earned his Bachelor’s and Master’s degrees in Mechanical Engineering at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts. His thesis was focused on the modeling of the International Space Station. Jose has also studied International Economics and Comparative Politics at Georgetown University in Washington, D.C., and received his MBA in France at INSEAD, where he focused on Finance and Globalization.

Continue reading “An Interview with Jose Cordeiro” | >

An estimated 30 million Americans are affected by osteoarthritis according to the CDC, and it is predominantly a disease of older age affecting more than 1 in 10 people aged 60+; with the aging population this number is likely to continue to rise steadily.

When cartilage naturally cushioning joints breaks down, osteoarthritis of the knee occurs, without this buffer bones can come into contact with each other causing pain, stiffness, and loss of flexibility.

Medications and physical interventions can ease symptoms of osteoarthritis, but currently there is no sure as it is not possible to regrow cartilage, once progressed to end stages the only option is surgical replacement of the joint. Stem cells were recently used to ease osteoarthritis in a small scale preliminary trial with promising results that will pave the way for more larger studies.

Read more

Stem cells are pluripotent cells, having a property of differentiating into various types of cells of human body. Several studies have developed mesenchymal stem cells (MSCs) from various human tissues, peripheral blood and body fluids. These cells are then characterized by cellular and molecular markers to understand their specific phenotypes. Dental pulp stem cells (DPSCs) are having a MSCs phenotype and they are differentiated into neuron, cardiomyocytes, chondrocytes, osteoblasts, liver cells and β cells of islet of pancreas. Thus, DPSCs have shown great potentiality to use in regenerative medicine for treatment of various human diseases including dental related problems. These cells can also be developed into induced pluripotent stem cells by incorporation of pluripotency markers and use for regenerative therapies of various diseases. The DPSCs are derived from various dental tissues such as human exfoliated deciduous teeth, apical papilla, periodontal ligament and dental follicle tissue. This review will overview the information about isolation, cellular and molecular characterization and differentiation of DPSCs into various types of human cells and thus these cells have important applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as scientists working in the field of oral pathology and oral medicine.

Keywords: Human dental pulp stem cells, Mesenchymal stem cells, Dentin, Pluripotency, Stem cell therapy, Molecular markers.

Core tip: Human dental pulp stem cells (DPSCs) have shown a potentiality for the treatment of various human diseases including dental related problems. The review will overview the information about DPSCs, their isolation, cellular and molecular characterization, differentiation into various types of cells and their applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as the scientists working in the field of oral pathology, oral medicine and regenerative medicine.

Read more