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Category: biotech/medical – Page 2173

The US government quietly resumed funding experiments on the deadly H5N1 avian flu — research that makes the virus more easily transmissible to mammals.

The researchers say making new strains of the H5N1 flu virus in a secure lab can help them see what might happen naturally in the real world. Sounds logical, but many scientists oppose it because the facts show most biosafety labs aren’t really secure at all, and experts say the risks of a mutated virus escaping outweigh whatever public health benefit comes from creating them.

But now the US government is funding these same labs again to artificially enhance potentially pandemic pathogens.

Continue reading “Hey, let’s fight global pandemics by maybe starting one… Say WHAT?” | >

DARPA, the Department of Defense’s research arm, is paying scientists to invent ways to instantly read soldiers’ minds using tools like genetic engineering of the human brain, nanotechnology and infrared beams. The end goal? Thought-controlled weapons, like swarms of drones that someone sends to the skies with a single thought or the ability to beam images from one brain to another.

This week, DARPA (Defense Advanced Research Projects Agency) announced that six teams will receive funding under the Next-Generation Nonsurgical Neurotechnology (N3) program. Participants are tasked with developing technology that will provide a two-way channel for rapid and seamless communication between the human brain and machines without requiring surgery.

“Imagine someone who’s operating a drone or someone who might be analyzing a lot of data,” said Jacob Robinson, an assistant professor of bioengineering at Rice University, who is leading one of the teams. [DARPA’s 10 Coolest Projects: From Humanoid Robots to Flying Cars].

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Belgian research groups from the VIB, Ghent University, Ghent University Hospital, and the biotech company Argenx have solved a century-long puzzle about the presence of protein crystals in asthma. Normally, proteins do not crystallize in the body, but there are some instances when this process does occur. Charcot-Leyden crystals are made from the protein galectin-10 and were discovered in the airways of asthmatics as early as 1853.

However, the have been largely ignored by scientists, and their actual link to disease remained unknown. The Belgian research groups have now established that the crystals are highly abundant in airway mucus, stimulate the immune system and promote the and altered mucus production that is often seen in the airways of asthmatics. Together, the academic and company scientists also developed antibodies that can dissolve these crystals to reduce key features. Such antibodies could be first-in-class therapeutics that reverse protein crystals and treat asthma and other chronic inflammatory diseases of the airways. The study is published in the leading journal Science.

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A molecule produced by the body during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.

“As people become older, they are more susceptible to disease, like cancer, cardiovascular disease and Alzheimer’s disease,” said Dr. Ming-Hui Zou, senior author of the study. “Age is the most important so-called risk factor for human disease. How to actually delay aging is a major pathway to reducing the incidence and severity of human disease.

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People who suffer a stroke caused by bleeding in the brain—known as brain haemorrhage—can take common medicines without raising their risk of another stroke, a major clinical trial has found.

Researchers say the findings are reassuring for the thousands of people who take the medicines to reduce their and another common type of caused by in the .

These everyday treatments—known as medicines—work by slowing or stopping blood from clotting. They are often prescribed to because they can lower risk of attack and stroke caused by a blood clot.

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A team of researchers affiliated with several institutions in Korea and Australia have found a possible link between the gut microbiome in infants and development of allergies. In their paper published in the journal Science Advances, the group describes their study of a certain antibody response in young mice and what they found.

Food allergies have been widely reported in the past few years, particularly in children. Scientists have been taking a closer look at the causes of the seemingly sudden rise in the number of people who are allergic to certain foods. In this new effort, the researchers looked into the possibility of a connection between food allergies and the gut biome.

The research started after some noticed that raised in a sterile environment (who also had no gut microbiome) expressed higher levels of immunoglobulin E (IgE) when they matured enough to start eating solid food. Prior research has shown that IgE is a mediator that plays a role during an allergic response—when allergens are detected, IgEs send out signals alerting other parts of the immune system, which in turn release chemicals that result in inflammation, a major allergy symptom.

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Injection of human neural stem cells into the spinal cord of people with amyotrophic lateral sclerosis (ALS) was found safe and did not cause adverse effects even two years after the transplant, results from a Phase 1 clinical trial show.

Trial findings were published in the study, “Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome,” in the journal Stem Cells Translational Medicine.

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A new Cornell University-led study finds that the genome for a widely researched worm, on which countless studies are based, was flawed. Now, a fresh genome sequence will set the record straight and improve the accuracy of future research.

When scientists study the genetics of an organism, they start with a standard genome sequenced from a single strain that serves as a baseline. It’s like a chess board in a chess game: every board is fundamentally the same.

One model organism that scientists use in research is a worm called Caenorhabditis elegans. The worm—the first multicellular eukaryote (animal, plant or fungus) to have its genome sequenced—is easy to grow and has simple biology with no bones, heart or circulatory system. At the same time, it shares many genes and molecular pathways with humans, making it a go-to model for studying gene function, drug treatments, aging and human diseases such as cancer and diabetes.

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