A COVID testing site says it has detected what is believed to be the first ‘flurona’ co-infection, a combination of influenza and coronavirus, in Los Angeles County.
Category: biotech/medical – Page 1,530
Parkinson’s Drug Discovery Collaboration Between Astrogen, Iktos to Leverage AI Platform
Artificial intelligence drug design company Iktos, and South Korean clinical research biotech Astrogen announced today a collaboration with the goal of discovering small-molecule pre-clinical drug candidates for a specific, undisclosed, marker of Parkinson’s disease (PD).
Under the terms of the agreement, whose value was not disclosed, Iktos will apply its generative learning algorithms which seek to identify new molecular structures with the potential address the target in PD. Astrogen, which has a focus of the development of therapeutics for “intractable neurological diseases,” will provide in-vitro and in-vivo screening of lead compounds and pre-clinical compounds. While both companies will contribute to the identification of new small-molecule candidates, Astrgoen will lead the drug development process from the pre-clinical stages.
“Our objective is to expedite drug discovery and achieve time and cost efficiencies for our global collaborators by using Iktos’s proprietary AI platform and know-how,” noted Yann Gaston-Mathé, president and CEO of Paris-based Iktos in a press release. “We are confident that together we will be able to identify promising novel chemical matter for the treatment of intractable neurological diseases. Our strategy has always been to tackle challenging problems alongside our collaborators where we can demonstrate value generation for new and on-going drug discovery projects.”
Ancient Lions and Bears Colonized North America in Multiple Waves, DNA Study Says
Researchers from the University of Adelaide and elsewhere have sequenced and analyzed mitochondrial DNA from fossils of cave lions (Panthera spp.) and brown bears (Ursus arctos), two megafaunal carnivorans that dispersed from Eurasia into North America during the Pleistocene, to better understand the timing and drivers of their past movement between the continents across the Bering Land Bridge. Their results reveal striking synchronicity in the population dynamics of Beringian lions and brown bears, with multiple waves of dispersal across the Bering Land Bridge. The evolutionary histories of these two megafaunal animals underline the crucial biogeographical role of the Bering Land Bridge in the distribution, turnover and maintenance of megafaunal populations in North America.
Dr. Maximina Yun, Ph.D. — Unlocking Secrets Of Salamander Regeneration For Regenerative Therapies
Unlocking The Secrets Of Salamander Regeneration For Regenerative Therapies — Dr. Maximina Yun, Ph.D., CRTD / Center for Regenerative Therapies TU Dresden, Technische Universität Dresden.
Dr. Maximina Yun, Ph.D. (https://tu-dresden.de/cmcb/crtd/forschungsgruppen/crtd-forsc…oup-leader) is Research Group Leader at the Center for Regenerative Therapies Dresden (CRTD), Technical University Dresden, jointly affiliated with Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG).
Dr. Yun and her group (https://tu-dresden.de/cmcb/crtd/forschungsgruppen/crtd-forschungsgruppen/yun) study the cellular and molecular basis of regeneration of complex structures with the help of salamanders (like newts and axolotls) and these vertebrates exceptional regenerative abilities, which in contrast to humans, are capable of regenerating complex tissues, and even entire organs, to a remarkable extent. Therefore, they offer unique insights into what molecular mechanisms must be in place for achieving quasi-perfect regeneration.
Research in the Yun group focuses on three main areas: describing cellular and molecular mechanisms driving regeneration (Mechanisms underlying the plasticity of the differentiated state), their connection with cellular aging (Role and regulation of senescence in regeneration), and the role that the immune system plays in regenerative context.
The research in the Yun group combines advanced molecular biology methods with state-of-the-art microscopy. Most recently the group has established Salamander-Eci, a novel method that enables the three-dimensional visualization of salamander tissues for a more comprehensive understanding of regenerative processes.
Commercial AI system enables autonomous detection of vision-threatening diabetic retinopathy
An artificial intelligence (AI) system that can identify diabetic retinopathy (DR) without physician assistance, including the most serious form that puts patients at risk of blindness, has outperformed expectations in a clinical trial. The commercial system successfully detected the presence and severity of the disease in 97% of eyes analysed. Deployment of such AI systems in primary care facilities for use by non-specialists could significantly increase access to eye exams that include DR evaluation, aiding in the diagnosis and treatment of the disease.
An artificial intelligence system that simplifies diabetes retinal screening could help save the vision of millions of people around the world.
Robot use on the rise as restaurants and retailers experience labor shortages
Yahoo Finance’s Dani Romero reports on the increasing use of robots and automation by restaurants and retailers amid the pandemic and labor shortages.
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Biomedical Research Leads Science’s 2021 Breakthroughs
Hi everyone, I’m Larry Tabak. I’ve served as NIH’s Principal Deputy Director for over 11 years, and I will be the acting NIH director until a new permanent director is named. In my new role, my day-to-day responsibilities will certainly increase, but I promise to carve out time to blog about some of the latest research progress on COVID-19 and any other areas of science that catch my eye.
I’ve also invited the directors of NIH’s Institutes and Centers (ICs) to join me in the blogosphere and write about some of the cool science in their research portfolios. I will publish a couple of posts to start, then turn the blog over to our first IC director. From there, I envision alternating between posts from me and from various IC directors. That way, we’ll cover a broad array of NIH science and the tremendous opportunities now being pursued in biomedical research.
Since I’m up first, let’s start where the NIH Director’s Blog usually begins each year: by taking a look back at Science’s Breakthroughs of 2021. The breakthroughs were formally announced in December near the height of the holiday bustle. In case you missed the announcement, the biomedical sciences accounted for six of the journal Science’s 10 breakthroughs. Here, I’ll focus on four biomedical breakthroughs, the ones that NIH has played some role in advancing, starting with Science’s editorial and People’s Choice top-prize winner: