Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1,531

The third episode of our podcast, ImmortaliCast, is now available! We interviewed Didier Coeurnelle, chair and co-founder of HEALES, and Marion Steenacker, biologist from HEALES, who updated us on the partial results from the lifespan experiments on rats conducted by Harold Katcher and Rodolfo Goya and funded by HEALES. Didier also discusses the more important trends in the rejuvenation field, and the other activities and goals of HEALES.

You can watch this episode via YouTube or on the main podcast platforms:

#science #rejuvenation #aging #medicine #health #heales #lifespan #biology #plasma #HaroldKatcher #RodolfoGoya

In this interview for the podcast ImmortaliCast, Didier Coeurnelle, chair and co-founder of HEALES (https://heales.org/), and Marion Steenacker, biologist from HEALES, update us on the partial results from the lifespan experiments on rats conducted by Harold Katcher and Rodolfo Goya and funded by HEALES (https://heales.org/2020/12/22/studies-financed-by-heales-eff…er-2020/). Didier also discusses the more important trends in the rejuvenation field, and the other activities and goals of HEALES.

The Fable of the Dragon-Tyrant:

Continue reading “Didier Coeurnelle: update on rats lifespan experiments” | >

It’s bad out there for customers of electronic parts and components. The semiconductor shortage is so severe it’s being covered by mainstream media; meanwhile, various politicians have tasked their aides with looking at the global supply chain. Indeed, in the short term, the dearth of chips is already leading to product delays, companies redesigning their parts, and higher device prices. But over the long term, it could usher in a complete rethink of the way electronics parts are designed.

Peggy Carrieres, VP of global sales development and supplier enablement at Avnet, told me she expects the shortage to contribute to engineers reducing the number of physical components used and turning instead to software to handle functions that had historically been done in hardware. The shortages tied to the pandemic are an accelerator for this shift, but it has been happening for years as the industry adjusts to the end of Moore’s Law and the ability to eke out more performance at lower costs.

I had reached out to Avnet because I was interested in what it was seeing from its customers as the chip shortage dragged on. Avnet is a distributor, so it acts as a middleman between electronics components suppliers and the end customers of those parts. Someone building a new electronic device could work with Avnet to source the parts from an existing design, for example, or to build a design out of available parts that fit within a specific price.

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“Gene editing offers unique opportunities to make food production more sustainable and to further improve the quality, but also the safety, of food. With the help of these new molecular tools, more robust plants can be developed that deliver high yields for high-quality nutrition, even with less fertiliser,” says co-author Stephan Clemens, Professor of Plant Physiology at the University of Bayreuth and founding Dean of the new Faculty of Life Sciences: Food, Nutrition & Health on the Kulmbach campus.

For more sustainability on a global level, EU legislation should be changed to allow the use of gene editing in organic farming. This is what an international research team involving the Universities of Bayreuth and Göttingen demands in a paper published in the journal “Trends in Plant Science”.

In May 2020, the EU Commission presented its “Farm-to-Fork” strategy, which is part of the “European Green Deal”. The aim is to make European agriculture and its food system more sustainable. In particular, the proportion of organic farming in the EU’s total agricultural land is to be increased to 25 percent by 2030. However, if current EU legislation remains in place, this increase will by no means guarantee more sustainability, as the current study by scientists from Bayreuth, Göttingen, Düsseldorf, Heidelberg, Wageningen, Alnarp, and Berkeley shows.

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Large swaths of U.S. military land are covered with munitions components, including the explosive chemical RDX. This molecule is toxic to people and can cause cancer. It also doesn’t naturally break down and can contaminate groundwater. Now researchers have genetically engineered a grass commonly used to fight soil erosion so that it can remove RDX from the soil, according to a new paper published May 3 in Nature Biotechnology.

A team, which includes researchers from the University of Washington, demonstrated that over the course of three years, a genetically engineered switchgrass could break down an explosive chemical in…

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At Rehab, a nurse explained to me that my swallowing problem was caused by weak muscles in the esophageal sphincter. That information stimulated me to create my own therapy for the esophageal sphincter. I wrote out the transcript for the therapy, and a lady named Collette read it into a recorder. I listen to the recording several times a day. My swallowing problems resulted in a feeding being inserted up my nose. The therapy makes it possible for me to eat oatmeal, grits, eggs, pasta & beef, and corn flakes. After passing the swallowing test last Friday, the Speech Pathologist sent me to the Emergency Room, where they pulled the feeding tube from my nose.

Dysphagia refers to the difficulty in swallowing after a stroke. It is a problem that can be easily managed with proper medical care.

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Papers referenced in the video:

Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk:
https://www.jacc.org/doi/10.1016/j.jacc.2020.10.

The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling:
https://www.sciencedirect.com/science/article/pii/S0753332220309781

Joint distribution of lipoprotein cholesterol classes. The Framingham study:
https://pubmed.ncbi.nlm.nih.gov/6573877/

Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS):
https://pubmed.ncbi.nlm.nih.gov/20223457/

Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease:

Continue reading “VLDL Increases During Aging, And Is Associated With Adverse Cardiovascular Outcomes” | >

Criticism of a recent video denouncing resveratrol.

Following Doctor Brad Stanfield’s latest ‘why I stopped video’, this last one about resveratrol and pterostilbene, many of you asked for my opinion, well here it is.

DoNotAge.org 10% Discount Code: MYNMN (https://bit.ly/3oaKgLv)
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I hope you enjoy my content and find it interesting or informative, hopefully both, if so, please consider supporting the channel by signing up to the one you prefer:

*Buy me a Kofi: https://ko-fi.com/mynmnexperiment.

Continue reading “Why Dr. Brad Stanfield Needed to Apologize” | >

Humans are distinguished from other species by several aspects of cognition. While much comparative evolutionary neuroscience has focused on the neocortex, increasing recognition of the cerebellum’s role in cognition and motor processing has inspired considerable new research. Comparative molecular studies, however, generally continue to focus on the neocortex. We sought to characterize potential genetic regulatory traits distinguishing the human cerebellum by undertaking genome-wide epigenetic profiling of the lateral cerebellum, and compared this to the prefrontal cortex of humans, chimpanzees, and rhesus macaque monkeys. We found that humans showed greater differential CpG methylation–an epigenetic modification of DNA that can reflect past or present gene expression–in the cerebellum than the prefrontal cortex, highlighting the importance of this structure in human brain evolution. Humans also specifically show methylation differences at genes involved in neurodevelopment, neuroinflammation, synaptic plasticity, and lipid metabolism. These differences are relevant for understanding processes specific to humans, such as extensive plasticity, as well as pronounced and prevalent neurodegenerative conditions associated with aging.

Citation: Guevara EE, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, Sherwood CC (2021) Comparative analysis reveals distinctive epigenetic features of the human cerebellum. PLoS Genet 17: e1009506. https://doi.org/10.1371/journal.pgen.

Editor: Takashi Gojobori, National Institute of Genetics, JAPAN.

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