Dr. Karen Miga, a co-lead of the T2T consortium and professor at the University of California, Santa Cruz, told Medical News Today, “The availability of a complete genome sequence will advance our understanding of the most difficult-to-sequence and repeat-rich parts of the human genome.”
“In the future, when someone has their genome sequenced, researchers and clinicians will be able to identify all of the variants in their DNA and use that information to better guide their healthcare. Knowing the complete sequence of the human genome will provide a comprehensive framework for scientists to study human genomic variation, disease, and evolution.”
In a new trial conducted by the University of Cambridge, scientists were successfully able to de-age human skin cells by 30 years.
With age, the ability of cells to function properly declines. As a result, the NDA blueprint of people starts to accumulate signs of aging.
Researchers have used regenerative biology to create ‘’induced’’ stem cells and produce fibroblasts that generates collagens that heal wounds and provide structure to tissues.
A team of researchers have found a way to “time jump” cells back 30 years. A team of researchers at the Babraham Institute, a partner organization of the University of Cambridge, UK, have made a breakthrough in regenerative medicine. Just published in the journal eLife, the team shows how they managed to turn back the clock 30 years for human skin cells.
A new regenerative medicine technique has been developed that can make old human cells 30 years younger without losing specialization.
Coming off multiple country approvals for his “patent free” Covid vaccine, Scientist, Researcher, Author, Science Explainer, Dr. Peter Hotez, MD, Ph.D. Baylor College of Medicine, drops by for an episode of Progress, Potential, And Possibilities.
Dr. Hotez is an internationally recognized physician-scientist with expertise in neglected tropical diseases and vaccine development. He leads the only product development partnership for developing new vaccines for hookworm, schistosomiasis and Chagas disease, and is just coming off a major win for emergency use approval of his team’s Corbevax protein sub-unit COVID-19 vaccine, of which he, and previous guest to the show, Dr. Maria Elena Bottazzi, were recently nominated for a Nobel Prize.
Dr. Hotez is the author of more than 400 original papers, as well as the books Forgotten People, Forgotten Diseases — The Neglected Tropical Diseases and Their Impact on Global Health and Development, Blue Marble Health — An Innovative Plan to Fight Diseases of the Poor amid Wealth, Vaccines Did Not Cause Rachel’s Autism: My Journey as a Vaccine Scientist, Pediatrician, and Autism Dad, and Preventing the Next Pandemic: Vaccine Diplomacy in a Time of Anti-science.
Michael Fossel, Telocyte. Aging: Understanding it, Reversing it.
Michael Fossel is Founder and President of Telocyte. He served as the executive director of the American Aging Association, has published more than 100 articles, books, and chapters on age-related disease and the potential for effective intervention via gene therapy, as well as have served as both an advisor to and board member for several biotechnology companies prior to Telocyte.
Santiago Ramón y Cajal, a Spanish physician from the turn of the 19th century, is considered by most to be the father of modern neuroscience. He stared down a microscope day and night for years, fascinated by chemically stained neurons he found in slices of human brain tissue. By hand, he painstakingly drew virtually every new type of neuron he came across using nothing more than pen and paper. As the Charles Darwin for the brain, he mapped every detail of the forest of neurons that make up the brain, calling them the “butterflies of the brain”. Today, 200 years later, Blue Brain has found a way to dispense with the human eye, pen and paper, and use only mathematics to automatically draw neurons in 3D as digital twins. Math can now be used to capture all the “butterflies of the brain”, which allows us to use computers to build any and all the billons of neurons that make up the brain. And that means we are getting closer to being able to build digital twins of brains.
These billions of neurons form trillions of synapses – where neurons communicate with each other. Such complexity needs comprehensive neuron models and accurately reconstructed detailed brain networks in order to replicate the healthy and disease states of the brain. Efforts to build such models and networks have historically been hampered by the lack of experimental data available. But now, scientists at the EPFL Blue Brain Project using algebraic topology, a field of Math, have created an algorithm that requires only a few examples to generate large numbers of unique cells. Using this algorithm – the Topological Neuronal Synthesis (TNS), they can efficiently synthesize millions of unique neuronal morphologies.
Through experimentation with a highly promising anti-aging technique, scientists at the UK’s Babraham Institute have demonstrated a new way of turning back the clock in human skin cells. These cells functioned like cells 30 years younger, but in what represents an exciting advance in the field, were able to still retain some of their specialized functions acquired through age.
In 2012, Japanese researcher Shinya Yamanaka earned a Nobel Prize for his work in developing what are known as induced pluripotent stem cells (iPSCs). These start out as regular adult tissue cells that are harvested and exposed to four molecules called Yamanaka factors, which return them to an immature state. From here, the stem cells can theoretically develop into any cell type in the body.
We’ve seen scientists explore this potential in a number of exciting ways, implanting them in rabbits to restore vision, addressing dopamine deficiencies in animal models of Parkinson’s disease and repairing damaged heart muscles in pigs. The full reprogramming process involves subjecting the cells to the Yamanaka factors for around 50 days, but the Babraham scientists have found that shortening this process might bring some significant benefits to the table.
Findings could lead to targeted approach for treating aging.
Research from the Babraham Institute has developed a method to ‘time jump’ human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute’s Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today (April 7, 2022) in the journal eLife and whilst at an early stage of exploration, it could revolutionize regenerative medicine.
The furious debate over Aduhelm has now sparked controversy over the Alliance for Aging Research, which has seen half of its scientific advisory board members resign.
